Influence of spondias mombin supplementation on the cardiac remodeling after acute myocardial infarction

• Grant number: 15/18502-8
• Support Opportunities: Regular Research Grants
• Duration: March 01, 2016 - February 28, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Marcos Ferreira Minicucci
• Grantee: Marcos Ferreira Minicucci
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated researchers: Bertha Furlan Polegato ; Leonardo Antonio Mamede Zornoff ; Paula Schmidt Azevedo Gaiolla ; Sergio Alberto Rupp de Paiva

Abstract

Cardiovascular diseases are the major cause of death in the world and it is estimated that, in 2030, they will be responsible for approximately 23.6 million deaths. Among cardiovascular diseases, we can highlight acute coronary syndromes, especially acute myocardial infarction (AMI). Heart failure is a frequent complication after the AMI and several factors influence its development, one of these factors is cardiac remodeling. The increased oxidative stress and inflammation process are associated with cardiac remodeling after the AMI. Due to the great economic and social impact and the high mortality rates, it is important to identify other factors that attenuate cardiac remodeling process. Among these factors are the food supplementation with antioxidant properties, such as Spondias mombin (SM). It is believed that its beneficial effects are attributed to the phenolic compounds, flavonoids and carotenoids present in the fruit. One study evaluated the administration of SM in a myocardial injury induced by isoproterenol and observed increased activity of superoxide dismutase and catalase and decreased concentrations of glutathione and malondealdeído. However, the SM influence on cardiac remodeling after the AMI was not studied yet. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BUZATI PEREIRA, BRUNA LETICIA; RODRIGUE, ALEXANE; DE OLIVEIRA ARRUDA, FERNANDA CAROLINE; BACHIEGA, TATIANA FERNANDA; MARTINS LOURENCO, MARIA ANGELICA; CORREA, CAMILA RENATA; AZEVEDO, PAULA SCHMIDT; POLEGATO, BERTHA FURLAN; OKOSHI, KATASHI; HENRIQUE FERNANDES, ANA ANGELICA; et al. Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 24, n. 14, p. 7862-7872, JUL 2020. (18/03082-1, 15/18502-8, 14/23215-5)

BUZATI PEREIRA, BRUNA LETICIA; RODRIGUE, ALEXANE; DE OLIVEIRA ARRUDA, FERNANDA CAROLINE; BACHIEGA, TATIANA FERNANDA; MARTINS LOURENCO, MARIA ANGELICA; CORREA, CAMILA RENATA; AZEVEDO, PAULA SCHMIDT; POLEGATO, BERTHA FURLAN; OKOSHI, KATASHI; HENRIQUE FERNANDES, ANA ANGELICA; et al. Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, MAY 2020. (15/18502-8, 14/23215-5, 18/03082-1)