Relationship among clinical, pulmonary function and biomarkers of immune system in moderate to severe asthma patients.

• Grant number: 15/21177-1
• Support Opportunities: Regular Research Grants
• Duration: March 01, 2016 - February 28, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Ana Luisa Godoy Fernandes
• Grantee: Ana Luisa Godoy Fernandes
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Asthma is an inflammatory disease characterized clinical symptoms including the reversibility of airflow limitation, airway hyperresponsiveness and inflammatory cells and broncoconstruction. The first line therapy used are combination of anti-inflammatory agents (corticosteroids, and leukotriene receptor antagonists) and bronchodilators (²2 agonists), but the response to the treatment is insufficient in many cases. New specific immunobiologic drugs have been used with inconclusive results and high costs. Asthma is a heterogeneous disease phenotypes have been described and classified in many ways depending on the trigger factors, atopy, disease severity, pattern of airway obstruction, inflammatory pattern and clinical phenotypes. Each phenotype responds to treatment differently characterizing the complexity of asthma with respect to interactions between genes and the environment. Phenotyping of asthma is important for characterization of pathophysiology, predicting prognosis, patient selection in clinical trials and personalized therapies choices. Recent studies have identified new molecular markers in blood, nasal lavage and sputum, as well as demonstrate the different responses to specific and conventional therapies. The objectives of this study are to characterize the inflammatory profile of adult asthmatic patients followed at the Pulmonology Department of asthma clinic of the Hospital São Paulo, by phenotyping with clinical questionnaires, control and evaluation of quality of life, spirometric measurements and tests immunologic in vivo and in vitro related to biopharmaceuticals and functional aspects of patients (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE FARIAS, CAMYLA F.; AMORIM, MARIA M. F.; DRACOULAKIS, MICHEL; CAETANO, LILIAN B.; SANTORO, ILKA L.; FERNANDES, ANA L. G.. Nasal lavage, blood or sputum: Which is best for phenotyping asthma?. Respirology, v. 22, n. 4, p. 671-677, MAY 2017. (12/11396-0, 15/21177-1)