Light/dark regulation of bone marrow stem cell production of blood and immune cells during homeostasis and inflammation

• Grant number: 15/50166-8
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2016
• End date: January 31, 2019
• Field of knowledge: Biological Sciences - Physiology - General Physiology
• Agreement: Weizmann Institute of Science
• Principal Investigator: Regina Pekelmann Markus
• Grantee: Regina Pekelmann Markus
• Principal researcher abroad: Tsvee Lapidot
• Institution abroad: Weizmann Institute of Science, Israel
• Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Our collaborative project aims at understanding how light/dark dependent signals regulate physiologic immune-cell generation and host-defense as part of homeostasis and in response to inflammatory insult. Identificating regulatory mechanisms and key molecules will provide new targets for improving clinical procedures such as stem cell transplantation and immunotherapy. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GOLAN, KARIN; KUMARI, ANJU; KOLLET, ORIT; KHATIB-MASSALHA, EMAN; SUBRAMANIAM, MOHANA DEVI; FERREIRA, ZULMA S.; AVEMARIA, FRANCESCA; RZESZOTEK, SYLWIA; GARCIA-GARCIA, ANDRES; XIE, STEPHANIE; et al. Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance. CELL STEM CELL, v. 23, n. 4, p. 572+, OCT 4 2018. (15/50166-8)

GOLAN, KARIN; KOLLET, ORIT; MARKUS, REGINA P.; LAPIDOT, TSVEE. Daily light and darkness onset and circadian rhythms metabolically synchronize hematopoietic stem cell differentiation and maintenance: The role of bone marrow norepinephrine, tumor necrosis factor, and melatonin cycles. Experimental Hematology, v. 78, p. 1-10, OCT 2019. (15/50166-8)