Advanced search
Start date
Betweenand

Light/dark regulation of bone marrow stem cell production of blood and immune cells during homeostasis and inflammation

Grant number: 15/50166-8
Support type:Regular Research Grants
Duration: February 01, 2016 - January 31, 2019
Field of knowledge:Biological Sciences - Physiology
Cooperation agreement: Weizmann Institute of Science
Principal Investigator:Regina Pekelmann Markus
Grantee:Regina Pekelmann Markus
Principal investigator abroad: Tsvee Lapidot
Institution abroad: Weizmann Institute of Science, Israel
Home Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Our collaborative project aims at understanding how light/dark dependent signals regulate physiologic immune-cell generation and host-defense as part of homeostasis and in response to inflammatory insult. Identificating regulatory mechanisms and key molecules will provide new targets for improving clinical procedures such as stem cell transplantation and immunotherapy. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Melatonin may help boost the success of bone marrow transplants 
Articles published in other midia outlets (2 total):
La melatonina puede elevar el índice de éxito de los trasplantes de médula 
La melatonina puede ayudar a aumentar el éxito de los transplantes de médula 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOLAN, KARIN; KUMARI, ANJU; KOLLET, ORIT; KHATIB-MASSALHA, EMAN; SUBRAMANIAM, MOHANA DEVI; FERREIRA, ZULMA S.; AVEMARIA, FRANCESCA; RZESZOTEK, SYLWIA; GARCIA-GARCIA, ANDRES; XIE, STEPHANIE; FLORES-FIGUEROA, EUGENIA; GUR-COHEN, SHIRI; ITKIN, TOMER; LUDIN-TAL, AYA; MASSALHA, HASSAN; BERNSHTEIN, BIANA; CIECHANOWICZ, ANDRZEJ K.; BRANDIS, ALEXANDER; MEHLMAN, TEVIE; BHATTACHARYA, SUDITI; BERTAGNA, MAYLA; CHENG, HUI; PETROVICH-KOPITMAN, EKATERINA; JANUS, TOMASZ; KAUSHANSKY, NATHALI; CHENG, TAO; SAGI, IRIT; RATAJCZAK, MARIUSZ Z.; MENDEZ-FERRER, SIMON; DICK, JOHN E.; MARKUS, REGINA P.; LAPIDOT, TSVEE. Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance. CELL STEM CELL, v. 23, n. 4, p. 572+, OCT 4 2018. Web of Science Citations: 9.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
Distribution map of accesses to this page
Click here to view the access summary to this page.