Evaluation of the role of estrogen in dentofacial development

• Grant number: 15/06866-5
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: April 01, 2016
• End date: July 31, 2019
• Field of knowledge: Health Sciences - Dentistry - Pediatric Dentistry
• Principal Investigator: Erika Calvano Kuchler
• Grantee: Erika Calvano Kuchler
• Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Léa Assed Bezerra da Silva ; Paulo Nelson Filho ; Raquel Assed Bezerra da Silva
• Associated scholarship(s): 18/03533-3 - Association between genetic variations in RANK, RANKL and OPG with dental size, BP.IC; 16/13982-4 - Evaluation of the role of estrogen in the growth and development of the maxilla and mandible, BP.MS; 16/08149-1 - Evaluation of the role of estrogen in dentofacial tissues, BP.JP

Abstract

Alterations of hormone levels can alter the development of the dentofacial complex, resulting in phenotypic alterations. It is known that estrogen and its receptors have a multifunctional role in the development and function of several tissues. Therefore, the objective of this proposal is to perform translational research in the dental field using animal models, human populations, and clinical and laboratory tools to evaluate the role of estrogen and its receptors in dentofacial development alterations. Ovariectomized rats in puberty will be used as an animal model for estrogen deficiency during the development of the dentofacial complex. The phenotypic alterations in the dentofacial complex will be evaluated clinically, radiographically, histopathologically, and by micro-CT. In addition, molecular biology techniques (RT-PCR and immunohistochemistry) will be used to access differentially expressed genes and microRNAs. In the human populations, saliva and DNA samples will be used. Real-time PCR will be used to evaluate the association between dentofacial phenotypic alterations with genetic variations in genes that encode the estrogen receptors (ERs), the osteoclastogenesis markers (RANK/RANKL/OPG), and microRNAs. For statistical analysis, parametric and/or nonparametric tests will be used. The consolidation of this project has the potential to generate novel knowledge and contribute to the development of a new research field and the internationalization of the Institution. (AU)

Scientific publications

(60)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CUNHA, ARTHUR S.; DOS SANTOS, LUIZA VERTUAN; PUGSLEY BARATTO, SAMANTHA SCHAFFER; ABBASOGLU, ZERRIN; GERBER, JENNIFER TSI; PAZA, ALEYSSON; NAKANE MATSUMOTO, MIRIAN AIKO; SCARIOT, RAFAELA; STUANI, MARIA BERNADETE; KUCHLER, ERIKA CALVANO. Human permanent tooth sizes are associated with genes encoding oestrogen receptors. JOURNAL OF ORTHODONTICS, SEP 2020. (15/06866-5)

SCARIOT, RAFAELA; BRUNET, LEONARDO; OLSSON, BERNARDO; PALINKAS, MARCELO; HALLAK REGALO, SIMONE CECILIO; BARBOSA REBELLATO, NELSON LUIS; BRANCHER, JOAO ARMANDO; TORRES, CAROLINA PAES; DIAZ-SERRANO, KRANYA VICTORIA; KUCHLER, ERIKA CALVANO; et al. ingle nucleotide polymorphisms in dopamine receptor D2 are associated with bruxism and its circadian phenotypes in childre. CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE, v. 40, n. 2, DEC 2019. (15/06866-5, 16/08149-1)

KUCHLER, ERIKA CALVANO; BRUZAMOLIN, CAROLINA DEA; OMORI, MARJORIE AYUMI; COSTA, MARCELO C.; ANTUNES, LEONARDO SANTOS; PECHARKI, GIOVANA DANIELA; TREVILATTO, PAULA CRISTINA; VIEIRA, ALEXANDRE REZENDE; BRANCHER, JOAO ARMANDO. Polymorphisms in Nonamelogenin Enamel Matrix Genes Are Associated with Dental Fluorosis. Caries Research, v. 52, n. 1-2, p. 1-6, 2018. (15/06866-5)

ARID, JULIANA; OLIVEIRA, DANIELA B.; EVANGELISTA, SILVANE S.; VASCONCELOS, KATIA R. F.; DUTRA, ANDRE L. T.; DE OLIVEIRA, SARA S.; DE QUEIROZ, ALEXANDRA M.; NELSON-FILHO, PAULO; VIEIRA, ALEXANDRE R.; KUCHLER, ERIKA C.. Oestrogen receptor alpha, growth hormone receptor, and developmental defect of enamel. International Journal of Paediatric Dentistry, v. 29, n. 1, p. 29-35, JAN 2019. (15/06866-5)

KUCHLER, ERIKA CALVANO; DO NASCIMENTO, MARIELE ANDRADE; NAKANE MATSUMOTO, MIRIAN AIKO; ROMANO, FABIO LOURENCO; BEZERRA DA SILVA, RAQUEL ASSED; OMORI, MARJORIE AYUMI; ANTUNES, LIVIA AZEREDO; ANTUNES, LEONARDO SANTOS; BEZERRA DA SILVA, LEA ASSED; NELSON-FILHO, PAULO. Genetic polymorphism in RANK is associated with mandibular size. JOURNAL OF ORTHODONTICS, v. 45, n. 3, p. 157-162, 2018. (16/08149-1, 16/13982-4, 15/06866-5)

RAPHAEL CARVALHO E SILVA; MARILIA BIANCHINI LEMOS REIS; JULIANA ARID; ELVIRA KATHERINE BARRIGA FLORES; GIUSEPPE VALDUGA CRUZ; GUIDO A. MARAÑÓN-VÁSQUEZ; LIZETE KARLA FILGUEIRAS DE SOUZA; ARTHUR BELÉM NOVAES JR; ALEXANDRA MUSSOLINO DE QUEIROZ; ERIKA CALVANO KÜCHLER. Association between Genetic Polymorphisms in RANK, RANKL and OPG and Peri-Implant Diseases in Patients from the Amazon Region. Brazilian Dental Journal, v. 31, n. 1, p. 63-68, 2020-03-06. (15/06866-5)

OMORI, MARJORIE AYUMI; GERBER, JENNIFER TSI; MARANON-VASQUEZ, GUIDO ARTEMIO; NAKANE MATSUMOTO, MIRIAN AIKO; WEISS, SUYANY GABRIELY; NASCIMENTO, MARIELE ANDRADE; DE SOUZA ARAUJO, MONICA TIRRE; SASSO STUANI, MARIA BERNADETE; NELSON-FILHO, PAULO; SCARIOT, RAFAELA; et al. Possible association between craniofacial dimensions and genetic markers in ESR1 and ESR2. JOURNAL OF ORTHODONTICS, v. 47, n. 1, p. 65-71, MAR 2020. (16/08149-1, 16/13982-4, 15/06866-5)

MARANON-VASQUEZ, GUIDO ARTEMIO; VIEIRA, ALEXANDRE R.; DE CARVALHO RAMOS, ALICE GOMES; DANTAS, BEATRIZ; ROMANO, FABIO LOURENCO; PALMA-DIBB, REGINA GUENKA; ARID, JULIANA; CARPIO, KARLA; NELSON-FILHO, PAULO; DE ROSSI, ANDIARA; et al. GHR and IGF2R genes may contribute to normal variations in craniofacial dimensions: Insights from an admixed population. AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, v. 158, n. 5, p. 722+, NOV 2020. (16/08149-1, 15/06866-5)

CUNHA, ARTHUR S.; DOS SANTOS, LUIZA VERTUAN; MARANON-VASQUEZ, GUIDO ARTEMIO; KIRSCHNECK, CHRISTIAN; GERBER, JENNIFER TSI; STUANI, MARIA BERNADETE; MATSUMOTO, MIRIAN AIKO NAKANE; VIEIRA, ALEXANDRE REZENDE; SCARIOT, RAFAELA; KUCHLER, ERIKA CALVANO. Genetic variants in tooth agenesis-related genes might be also involved in tooth size variations. CLINICAL ORAL INVESTIGATIONS, v. 25, n. 3, JUL 2020. (16/08149-1, 15/06866-5, 18/03533-3)

BARBALHO, MATHEUS; ROZIN KLEINER, ANA FRANCISCA; CALLEGARI, BIANCA; DE LIMA, RAMON COSTA; SOUZA, GIVAGO DA SILVA; COSTA E SILVA, ANSELMO DE ATHAYDE; COSWIG, VICTOR SILVEIRA. Assessing Interlimb Jump Asymmetry in Young Soccer Players: The My Jump 2 App. INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE, v. 16, n. 1, p. 19-27, JAN 2021. (15/06866-5)

ISABELA RIBEIRO MADALENA; CAIO LUIZ BITENCOURT REIS; DANIELA SILVA BARROSO DE OLIVEIRA; GIOVANA DANIELA PECHARKI; PAULA CRISTINA TREVILATTO; KESLY MARY RIBEIRO ANDRADES; JULIA CARELLI; VINICIUS LARANJEIRA BARBOSA DA SILVA; FLARES BARATTO-FILHO; ERIKA CALVANO KÜCHLER; et al. Lack of association between delayed tooth emergence and single nucleotide polymorphisms in estrogen receptors. Brazilian Dental Journal, v. 32, n. 6, p. 107-114, 2022-01-05. (16/08149-1, 15/06866-5)

ARID, JULIANA; ALVES ANTUNES, LIVIA AZEREDO; DE AZEVEDO KOCH, LUIZA FOLTRAN; EVANGELISTA, SILVANE SILVA; FELIZARDO VASCONCELOS, KATIA REGINA; BRANCHER, JOAO ARMANDO; LEAO GABARDO, MARILISA CARNEIRO; MILANI, ANA JULIA; TANNUS DUTRA, ANDRE LUIZ; ANTUNES, LEONARDO SANTOS; et al. Association of taste receptor gene polymorphisms with dental caries. BRAZILIAN ORAL RESEARCH, v. 34, p. 9-pg., 2020-01-01. (15/06866-5)

MACHADO, NILZA CRISTINA; GERBER, JENNIFER TSI; DOS SANTOS, KATHELEEN MIRANDA; BERGAMASCHI, ISABELA POLESI; MEGER, MICHELLE NASCIMENTO; DA COSTA, DELSON JOAO; KUCHLER, ERIKA CALVANO; SCARIOT, RAFAELA. Association of the estrogen receptor gene with oral health-related quality of life in patients with dentofacial deformities. BRAZILIAN ORAL RESEARCH, v. 36, p. 10-pg., 2022-01-01. (15/06866-5)

IGOR BASSI FERREIRA PETEAN; ALICE CORRÊA SILVA-SOUSA; TAMARA JUSTINIANO CRONENBOLD; JARDEL FRANCISCO MAZZI-CHAVES; LEA ASSED BEZERRA DA SILVA; RAQUEL ASSED BEZERRA SEGATO; GUILHERME ASSED PIEDADE DE CASTRO; ERIKA CALVANO KUCHLER; FRANCISCO WANDERLEY GARCIA PAULA-SILVA; MANOEL DAMIÃO SOUSA-NETO. Genetic, Cellular and Molecular Aspects involved in Apical Periodontitis. Brazilian Dental Journal, v. 33, n. 4, p. 1-11, 2022-08-26. (13/09595-7, 15/06866-5, 10/17611-4)

MADALENA, ISABELA RIBEIRO; XAVIER, THAIS APARECIDA; CRUZ, GIUSEPPE VALDUGA; BRANCHER, JOAO ARMANDO; BEZERRA DA SILVA, LEA ASSED; PAZA, ALEYSSON OLIMPIO; BEZERRA SEGATO, RAQUEL ASSED; KUCHLER, ERIKA CALVANO. Evaluation of vitamin D receptor genetic polymorphisms with dental caries and developmental defects of enamel in Brazilian children. PEDIATRIC DENTAL JOURNAL, v. 30, n. 3, p. 161-166, DEC 2020. (16/08149-1, 15/06866-5)

CUNHA, ARTHUR; NELSON-FILHO, PAULO; MARANON-VASQUEZ, GUIDO ARTEMIO; DE CARVALHO RAMOS, ALICE GOMES; DANTAS, BEATRIZ; SEBASTIANI, ALINE MONISE; SILVERIO, FELIPE; OMORI, MARJORIE AYUMI; RODRIGUES, AMANDA SILVA; TEIXEIRA, ELLEN CARDOSO; et al. Genetic variants in ACTN3 and MYO1H are associated with sagittal and vertical craniofacial skeletal patterns. ARCHIVES OF ORAL BIOLOGY, v. 97, p. 85-90, JAN 2019. (15/06866-5)

GERBER, JENNIFER TSI; DOS SANTOS, KATHELEEN MIRANDA; BRUM, BRUNA KARAS; PETINATI, MARIA FERNANDA PIVETTA; MEGER, MICHELLE NASCIMENTO; DA COSTA, DELSON JOAO; ELSALANTY, MOHAMMED; KUCHLER, ERIKA CALVANO; SCARIOT, RAFAELA. Odontogenesis-related candidate genes involved in variations of permanent teeth size. CLINICAL ORAL INVESTIGATIONS, v. 25, n. 7, p. 4481-4494, JUL 2021. (15/06866-5)

DALLEDONE, M.; CUNHA, A. S.; RAMAZZOTTO, L. A.; PECHARKI, G. D.; NELSON-FILHO, P.; SCARIOT, R.; TREVILATTO, P. C.; VIEIRA, A. R.; KUCHLER, ERIKA C.; BRANCHER, JOAO A.. Estrogen receptor gene is associated with dental fluorosis in Brazilian children. CLINICAL ORAL INVESTIGATIONS, v. 23, n. 9, p. 3565-3570, SEP 2019. (15/06866-5)

SILVA-SOUSA, ALICE CORREA; MARANON-VASQUEZ, GUIDO ARTEMIO; GERBER, JENNIFER TSI; JUDACHESCI, CLAUDIA S.; SASSO STUANI, MARIA BERNADETE; NAKANE MATSUMOTO, MIRIAN AIKO; COLETTA, RICARDO D.; SCARIOT, RAFAELA; KUCHLER, ERIKA CALVANO. Left-right asymmetry in palatal rugae is associated with genetic variants in WNT signaling pathway. ARCHIVES OF ORAL BIOLOGY, v. 110, FEB 2020. (15/06866-5)

FERREIRA PETEAN, IGOR BASSI; KUCHLER, ERIKA CALVANO; VILARINHO SOARES, ISADORA MELLO; BEZERRA SEGATO, RAQUEL ASSED; BEZERRA DA SILVA, LEA ASSED; ALVES ANTUNES, LIVIA AZEREDO; SALLES, ALESSANDRO GUIMARAES; ANTUNES, LEONARDO SANTOS; DE SOUSA-NETO, MANOEL DAMIAO. Genetic Polymorphisms in RANK and RANKL are Associated with Persistent Apical Periodontitis. JOURNAL OF ENDODONTICS, v. 45, n. 5, p. 526-531, MAY 2019. (15/06866-5)

ARID, JULIANA; XAVIER, THAIS APARECIDA; BEZERRA DA SILVA, RAQUEL ASSED; DE ROSSI, ANDIARA; BEZERRA DA SILVA, LEA ASSED; MUSSOLINO DE QUEIROZ, ALEXANDRA; GALO, RODRIGO; ALVES ANTUNES, LIVIA AZEREDO; BARBOSA SILVA, MARCELO JOSE; ANTUNES, LEONARDO SANTOS; et al. RANKL is associated with persistent primary teeth and delayed permanent tooth emergence. International Journal of Paediatric Dentistry, v. 29, n. 3, p. 294-300, MAY 2019. (15/09034-0, 15/06866-5)

XAVIER, THAIS APARECIDA; MADALENA, ISABELA RIBEIRO; BEZERRA DA SILVA, RAQUEL ASSED; BEZERRA DA SILVA, LEA ASSED; BARBOSA SILVA, MARCELO JOSE; DE ROSSI, ANDIARA; KUCHLER, ERIKA CALVANO; FUKADA, SANDRA YASUYO. Vitamin D deficiency is a risk factor for delayed tooth eruption associated with persistent primary tooth. ACTA ODONTOLOGICA SCANDINAVICA, v. 79, n. 8, p. 600-605, NOV 17 2021. (15/09034-0, 15/06866-5)

KUECHLER, ERIKA CALVANO; DE LARA, RAFAELA MARIANA; OMORI, MARJORIE AYUMI; MARANON-VASQUEZ, GUIDO; BARATTO-FILHO, FLARES; NELSON-FILHO, PAULO; STUANI, MARIA BERNADETE SASSO; BLANCK-LUBARSCH, MORITZ; SCHROEDER, AGNES; PROFF, PETER; et al. Effects of estrogen deficiency during puberty on maxillary and mandibular growth and associated gene expression - an mu CT study on rats. Head & Face Medicine, v. 17, n. 1, APR 22 2021. (15/06866-5)

GERBER, JENNIFER TSI; WEISS, SUYANY GABRIELY; MIJOLARO, LAURA VIDAL; SILVA, CAROLINA SIQUEIRA; PETINATI, MARIA FERNANDA PIVETTA; MEGER, MICHELLE NASCIMENTO; HONORIO, HEITOR MARQUES; REBELLATO, NELSON LUIS BARBOSA; SEBASTIANI, ALINE MONISE; KUCHLER, ERIKA CALVANO; et al. Polymorphisms in hormonal-related genes might be associated with variations in permanent tooth crown size. ORTHODONTICS & CRANIOFACIAL RESEARCH, v. 26, n. 4, p. 7-pg., 2023-03-07. (15/06866-5, 16/08149-1)

KUECHLER, ERIKA CALVANO; REIS, CAIO LUIZ BITENCOURT; MARANON-VASQUEZ, GUIDO; NELSON-FILHO, PAULO; MATSUMOTO, MIRIAN AIKO NAKANE; STUANI, MARIA BERNADETE SASSO; OLIVEIRA, MARIA ANGELICA HUEB DE MENEZES; PROFF, PETER; KIRSCHNECK, CHRISTIAN. Parathyroid Hormone Gene and Genes Involved in the Maintenance of Vitamin D Levels Association with Mandibular Retrognathism. JOURNAL OF PERSONALIZED MEDICINE, v. 11, n. 5, MAY 2021. (15/06866-5)

KUECHLER, ERIKA CALVANO; DE OLIVEIRA STROPARO, JEFERSON LUIS; BITENCOURT REIS, CAIO LUIZ; ULLRICH, NIKLAS; OLSSON, BERNARDO; SCARIOT, RAFAELA; MATSUMOTO, MIRIAN NAKANE; RIBEIRO MATTOS, NATANAEL HENRIQUE; PROFF, PETER; BARATTO-FILHO, FLARES; et al. Oral Cleft Related-Genes may be Involved in Root Curvature of Maxillary Lateral Incisors. CLEFT PALATE-CRANIOFACIAL JOURNAL, v. N/A, p. 7-pg., 2022-08-17. (15/06866-5)

KUCHLER, ERIKA CALVANO; HANNEGRAF, NATASCHA DOUAT; LARA, RAFAELA MARIANA; BITENCOURT REIS, CAIO LUIZ; BARROSO DE OLIVEIRA, DANIELA SILVA; MAZZI-CHAVES, JARDEL FRANCISCO; RIBEIRO ANDRADES, KESLY MARY; DE LIMA, LORENA FERREIRA; SALLES, ALESSANDRO GUIMARAES; ALVES ANTUNES, LIVIA AZEREDO; et al. Investigation of Genetic Polymorphisms in BMP2, BMP4, SMAD6, and RUNX2 and Persistent Apical Periodontitis. JOURNAL OF ENDODONTICS, v. 47, n. 2, p. 278-285, FEB 2021. (15/06866-5, 18/21130-3)

CALVANO KUCHLER, E.; ARID, J.; PALINKAS, M.; AYUMI OMORI, M.; DE LARA, R. M.; NAPOLITANO GONCALVES, L. M.; HALLAK REGALO, S. C.; PAES TORRES MANTOVANI, C.; REZENDE VIEIRA, A.; DIAZ-SERRANO, K.. Genetic Polymorphisms in ACTN3 Contribute to the Etiology of Bruxism in Children. Journal of Clinical Pediatric Dentistry, v. 44, n. 3, p. 180-184, 2020. (15/06866-5)

NILZA CRISTINA MACHADO; JENNIFER TSI GERBER; KATHELEEN MIRANDA DOS SANTOS; ISABELA POLESI BERGAMASCHI; MICHELLE NASCIMENTO MEGER; DELSON JOÃO DA COSTA; ERIKA CALVANO KÜCHLER; RAFAELA SCARIOT. Association of the estrogen receptor gene with oral health-related quality of life in patients with dentofacial deformities. Brazilian Oral Research, v. 36, 2022-07-11. (15/06866-5)

JULIANA ARID; LÍVIA AZEREDO ALVES ANTUNES; LUIZA FOLTRAN DE AZEVEDO KOCH; SILVANE SILVA EVANGELISTA; KATIA REGINA FELIZARDO VASCONCELOS; JOÃO ARMANDO BRANCHER; MARILISA CARNEIRO LEÃO GABARDO; ANA JULIA MILANI; ANDRÉ LUIZ TANNUS DUTRA; LEONARDO SANTOS ANTUNES; et al. Association of taste receptor gene polymorphisms with dental caries. Brazilian Oral Research, v. 34, 2020-06-19. (15/06866-5)

KUCHLER, ERIKA CALVANO; MEGER, MICHELLE NASCIMENTO; OMORI, MARJORIE AYUMI; GERBER, JENNIFER TSI; MARTINS NETO, EVANDRO CARNEIRO; DA SILVA MACHADO, NILZA CRISTINA; CAVALCANTE, RAFAEL CORREA; TEIXEIRA, LUCAS RIBEIRO; STUANI, MARIA BERNADETE; NELSON FILHO, PAULO; et al. Association between oestrogen receptors and female temporomandibular disorders. ACTA ODONTOLOGICA SCANDINAVICA, OCT 2019. (15/06866-5)

FATTURI, ALUHE LOPES; MENONCIN, BRUNA LETICIA; REYES, MAGDALENA TORRES; MEGER, MICHELLE; SCARIOT, RAFAELA; BRANCHER, JOAO ARMANDO; KUCHLER, ERIKA CALVANO; FELTRIN-SOUZA, JULIANA. The relationship between molar incisor hypomineralization, dental caries, socioeconomic factors, and polymorphisms in the vitamin D receptor gene: a population-based study. CLINICAL ORAL INVESTIGATIONS, MAR 2020. (15/06866-5)

DE LARA, RAFAELA MARIANA; DOS SANTOS, MATHEUS CAIRES; OMORI, MARJORIE AYUMI; BARATTO-FILHO, FLARES; BRANCHER, JOAO ARMANDO; NELSON-FILHO, PAULO; SCHROEDER, AGNES; KUCHLER, ERIKA CALVANO; TORRES, MARIA FERNANDA PIOLI; KIRSCHNECK, CHRISTIAN. The role of postnatal estrogen deficiency on cranium dimensions. CLINICAL ORAL INVESTIGATIONS, OCT 2020. (15/06866-5)

KUECHLER, ERIKA CALVANO; DE LARA, RAFAELA MARIANA; OMORI, MARJORIE AYUMI; SCHROEDER, AGNES; TEODORO, VINICIUS BROSKA; BARATTO-FILHO, FLARES; LEON, JORGE ESQUICHE; PROFF, PETER; MADALENA, ISABELA RIBEIRO; KIRSCHNECK, CHRISTIAN. strogen deficiency affects tooth formation and gene expression in the odontogenic region of female rat. ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, v. 236, JUL 2021. (15/06866-5)

SAMANTHA SCHAFFER PUGSLEY BARATTO; MICHELLE NASCIMENTO MEGER; VÂNIA CAMARGO; GISELE MARIA CORRER NOLASCO; NATANAEL HENRIQUE RIBEIRO MATTOS; LILIANE ROSKAMP; JOSÉ STECHMAN-NETO; ISABELA RIBEIRO MADALENA; ERIKA CALVANO KÜCHLER; FLARES BARATTO-FILHO. Temporomandibular disorder in construction workers associated with ANKK1 and DRD2 genes. Brazilian Dental Journal, v. 33, n. 4, p. 12-20, 2022-08-26. (15/06866-5, 16/08149-1)

HORTA, KARLA CARPIO; WEISS, SUYANY GABRIELY; MIRANDA, KATHELEEN; SEBASTIANI, ALINE MONISE; DA COSTA, DELSON JOAO; NAKANE MATSUMOTO, MIRIAN AIKO; MARANON-VASQUEZ, GUIDO ARTEMIO; VIEIRA, ALEXANDRE REZENDE; SCARIOT, RAFAELA; KUCHLER, ERIKA CALVANO. Polymorphisms in FGF3, FGF10, and FGF13 May Contribute to the Presence of Temporomandibular Disorders in Patients Who Required Orthognathic Surgery. JOURNAL OF CRANIOFACIAL SURGERY, v. 30, n. 7, p. 2082-2084, OCT 2019. (16/08149-1, 15/06866-5)

CUNHA, ARTHUR S.; DOS SANTOS, LUIZA VERTUAN; PUGSLEY BARATTO, SAMANTHA SCHAFFER; ABBASOGLU, ZERRIN; GERBER, JENNIFER TSI; PAZA, ALEYSSON; NAKANE MATSUMOTO, MIRIAN AIKO; SCARIOT, RAFAELA; STUANI, MARIA BERNADETE; KUCHLER, ERIKA CALVANO. Human permanent tooth sizes are associated with genes encoding oestrogen receptors. JOURNAL OF ORTHODONTICS, v. 48, n. 1, p. 9-pg., 2020-09-28. (15/06866-5)

BARBOSA, MARIANE C. F.; LIMA, DANIELA C.; REIS, CAIO L. B.; REIS, ANA L. M.; JR, DARLAN RIGO; SEGATO, RAQUEL A. B.; STORRER, CARMEN L. M.; KUCHLER, ERIKA C.; DE OLIVEIRA, DANIELA S. B.. Vitamin D receptor FokI and BglI genetic polymorphisms, dental caries, and gingivitis. International Journal of Paediatric Dentistry, v. 30, n. 5, p. 642-649, SEP 2020. (15/06866-5)

ABBASOGLU, ZERRIN; DALLEDONE, MARIANA; WAMBIER, LETICIA M.; PECHARKI, GIOVANA; BARATTO-FILHO, FLARES; ANDRADES, KESLY MARY R.; SCARIOT, RAFAELA; TREVILATTO, PAULA C.; BRANCHER, JOAO A.; KUCHLER, ERIKA C.. Single nucleotide polymorphism rs4284505 in microRNA17 and risk of dental fluorosis. ACTA ODONTOLOGICA SCANDINAVICA, v. 78, n. 6, JUL 2020. (15/06866-5, 16/08149-1)

VIEIRA, ALEXANDRE R.; SCARIOT, RAFAELA; GERBER, JENNIFER T.; ARID, JULIANA; KUCHLER, ERIKA C.; SEBASTIANI, ALINE M.; PALINKAS, MARCELO; DIAZ-SERRANO, V, KRANYA; TORRES, CAROLINA P.; REGALO, SIMONE C. H.; et al. Bruxism Throughout the Lifespan and Variants in MMP2, MMP9 and COMT. JOURNAL OF PERSONALIZED MEDICINE, v. 10, n. 2, JUN 2020. (15/06866-5)

KUECHLER, ERIKA CALVANO; REIS, CAIO LUIZ BITENCOURT; SILVA-SOUSA, ALICE CORREA; MARANON-VASQUEZ, GUIDO ARTEMIO; MATSUMOTO, MIRIAN AIKO NAKANE; SEBASTIANI, ALINE; SCARIOT, RAFAELA; PADDENBERG, EVA; PROFF, PETER; KIRSCHNECK, CHRISTIAN. Exploring the Association Between Genetic Polymorphisms in Genes Involved in Craniofacial Development and Isolated Tooth Agenesis. FRONTIERS IN PHYSIOLOGY, v. 12, SEP 1 2021. (15/06866-5)

SILVA-SOUSA, ALICE CORREA; MARANON-VASQUEZ, GUIDO ARTEMIO; SASSO STUANI, MARIA BERNADETE; PROFF, PETER; RIBEIRO ANDRADES, KESLY MARY; BARATTO-FILHO, FLARES; NAKANE MATSUMOTO, MIRIAN AIKO; PADDENBERG, EVA; KUECHLER, ERIKA CALVANO; KIRSCHNECK, CHRISTIAN. Genetic variants in bone morphogenetic proteins signaling pathway might be involved in palatal rugae phenotype in humans. SCIENTIFIC REPORTS, v. 11, n. 1, JUN 16 2021. (15/06866-5)

RODRIGUES, AMANDA SILVA; TEIXEIRA, ELLEN CARDOSO; ANTUNES, LEONARDO SANTOS; NELSON-FILHO, PAULO; CUNHA, ARTHUR SILVA; LEVY, SIMONE CARVALHO; ARAUJO, MONICA TIRRE DE SOUZA; RAMOS, ALICE GOMES DE CARVALHO; CRUZ, GIUSEPPE VALDUGA; OMORI, MARJORIE AYUMI; et al. Association between craniofacial morphological patterns and tooth agenesis-related genes. PROGRESS IN ORTHODONTICS, v. 21, n. 1, APR 6 2020. (16/08149-1, 15/06866-5)

ERIKA CALVANO KÜCHLER; RAQUEL FERNANDA GERLACH; ARTHUR S CUNHA; LUCAS A RAMAZZOTTO; PAULA PORTO SPADA; PAULO NELSON-FILHO; JUNIA RAMOS; GIOVANA DANIELA PECHARKI; FERNANDO BARBOSA JR; ALEXANDRE REZENDE VIEIRA; et al. Calcium and Phosphorus Levels in Saliva are Influenced by Genetic Polymorphisms in Estrogen Receptor Alpha and Microrna17. Brazilian Dental Journal, v. 31, n. 5, p. 466-470, 2020-11-02. (16/08149-1, 15/06866-5)

VASCONCELOS, KATIA REGINA; ARID, JULIANA; EVANGELISTA, SILVANE; OLIVEIRA, SARA; DUTRA, ANDRE LUIZ; BEZERRA SILVA, LEA ASSED; BEZERRA SEGATO, RAQUEL ASSED; VIEIRA, ALEXANDRE REZENDE; NELSON-FILHO, PAULO; KUCHLER, ERIKA CALVANO. MMP13 Contributes to Dental Caries Associated with Developmental Defects of Enamel. Caries Research, v. 53, n. 4, p. 441-446, 2019. (15/06866-5)

MARANON-VASQUEZ, GUIDO ARTEMIO; DANTAS, BEATRIZ; KIRSCHNECK, CHRISTIAN; ARID, JULIANA; CUNHA, ARTHUR; DE CARVALHO RAMOS, ALICE GOMES; OMORI, MARJORIE AYUMI; RODRIGUES, AMANDA SILVA; TEIXEIRA, ELLEN CARDOSO; LEVY, SIMONE CARVALHO; et al. Tooth agenesis-related GLI2 and GLI3 genes may contribute to craniofacial skeletal morphology in humans. ARCHIVES OF ORAL BIOLOGY, v. 103, p. 12-18, JUL 2019. (15/06866-5)

SCARIOT, RAFAELA; TOMAZ, CAMILA OLIVEIRA; CALIXTO, ROBSON DIEGO; GERBER, JENNIFER TSI; PIVETTA PETINATI, MARIA FERNANDA; CAVALCANTE, RAFAEL CORREIA; KUCHLER, ERIKA CALVANO; DA COSTA, DELSON JOAO. Association between gender, estrogen receptors genes and anxiety levels in patients undergoing orthognathic surgery. JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, v. 47, n. 8, p. 1300-1305, AUG 2019. (15/06866-5)

OMORI, MARJORIE AYUMI; MARANON-VASQUEZ, GUIDO ARTEMIO; ROMUALDO, PRISCILLA COUTINHO; NETO, EVANDRO CARNEIRO MARTINS; STUANI, MARIA BERNADETE SASSO; MATSUMOTO, MIRIAN AIKO NAKANE; NELSON-FILHO, PAULO; PROFF, PETER; LEON, JORGE ESQUICHE; KIRSCHNECK, CHRISTIAN; et al. Effect of ovariectomy on maxilla and mandible dimensions of female rats. ORTHODONTICS & CRANIOFACIAL RESEARCH, v. 23, n. 3, APR 2020. (16/08149-1, 16/13982-4, 15/06866-5)

ROMUALDO, PRISCILLA COUTINHO; PUCINELLI, CAROLINA MASCHIETTO; TANNURE, PATRICIA NIVOLONI; NELSON-FILHO, PAULO; BEZERRA SEGATO, RAQUEL ASSED; BRANCHER, JOAO ARMANDO; MAGALHAES, NILZA LETICIA; COSTA, MARCELO DE CASTRO; ANTUNES, LIVIA AZEREDO A.; ANTUNES, LEONARDO SANTOS; et al. Evaluation of genetic polymorphisms in MMP2, MMP9 and MMP20 in Brazilian children with dental fluorosis. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v. 66, p. 104-108, FEB 2019. (15/06866-5)

HORTA, KARLA C.; MARANON-VASQUEZ, GUIDO A.; MATSUMOTO, MIRIAN A. N.; MOREIRA, MARILIA R.; ROMANO, FABIO L.; CONSOLARO, ALBERTO; DE SOUZA, ISRAEL D.; BRIGANTE, TAMIRES A. V.; QUEIROZ, MARIA E. C.; NELSON-FILHO, PAULO; et al. Association between polymorphisms in genes encoding estrogen receptors (ESR1 and ESR2) and excreted bisphenol A levels after orthodontic bracket bonding: a preliminary study. PROGRESS IN ORTHODONTICS, v. 19, JUL 2 2018. (16/08149-1, 15/06866-5)

ERIKA CALVANO KÜCHLER; DRIELY BARREIROS; RAPHAELA OLIVEIRA DA SILVA; JÚLIA GUIMARÃES BARCELLOS DE ABREU; ELLEN CARDOSO TEIXEIRA; RAQUEL ASSED BEZERRA DA SILVA; LEA ASSED BEZERRA DA SILVA; PAULO NELSON FILHO; FÁBIO LOURENÇO ROMANO; JOSÉ MAURO GRANJEIRO; et al. Genetic Polymorphism in MMP9 May Be Associated With Anterior Open Bite in Children. Brazilian Dental Journal, v. 28, n. 3, p. 277-280, 2017-06-00. (15/06866-5)

ALICE CORRÊA SILVA-SOUSA; JARDEL FRANCISCO MAZZI-CHAVES; JESSICA VAVASSORI FREITAS; ALESSANDRO GUIMARÃES SALLES; RAQUEL ASSED BEZERRA DA SILVA SEGATO; LÉA ASSED BEZERRA DA SILVA; LÍVIA AZEREDO ALVES ANTUNES; LEONARDO SANTOS ANTUNES; FLARES BARATTO-FILHO; MANOEL DAMIÃO SOUSA-NETO; et al. Association between Estrogen, Vitamin D and Microrna17 Gene Polymorphisms and Periapical Lesions. Brazilian Dental Journal, v. 31, n. 1, p. 19-24, 2020-03-06. (15/06866-5)

BERGAMO, ANA ZILDA NAZAR; MADALENA, ISABELA RIBEIRO; OMORI, MARJORIE AYUMI; RAMAZZOTTO, LUCAS ALEXANDRE; NELSON-FILHO, PAULO; BARATTO-FILHO, FLARES; PROFF, PETER; KIRSCHNECK, CHRISTIAN; KUECHLER, ERIKA CALVANO. Estrogen deficiency during puberty affects the expression of microRNA30a and microRNA503 in the mandibular condyle. ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, v. 240, FEB 2022. (15/06866-5)

MEGER, MICHELLE NASCIMENTO; GERBER, JENNIFER TSI; AZEREDO, WILLIAN MARTINS; SEBASTIANI, ALINE MONISE; DELIBERADOR, TATIANA MIRANDA; KUCHLER, ERIKA CALVANO; KLUPPEL, LEANDRO EDUARDO; SCARIOT, RAFAELA. Genetic polymorphisms are involved in oral health-related quality of life in skeletal class III patients submitted to orthognathic surgery. CLINICAL ORAL INVESTIGATIONS, v. 27, n. 4, p. 13-pg., 2023-02-24. (15/06866-5)

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KUECHLER, ERIKA CALVANO; DE LARA, RAFAELA MARIANA; OMORI, MARJORIE AYUMI; SCHROEDER, AGNES; TEODORO, VINICIUS BROSKA; BARATTO-FILHO, FLARES; LEON, JORGE ESQUICHE; PROFF, PETER; MADALENA, ISABELA RIBEIRO; KIRSCHNECK, CHRISTIAN. Estrogen deficiency affects tooth formation and gene expression in the odontogenic region of female rats. ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, v. 236, p. 6-pg., 2021-03-04. (15/06866-5)

DE LARA, RAFAELA MARIANA; DOS SANTOS, MATHEUS CAIRES; OMORI, MARJORIE AYUMI; BARATTO-FILHO, FLARES; BRANCHER, JOAO ARMANDO; NELSON-FILHO, PAULO; SCHROEDER, AGNES; KUCHLER, ERIKA CALVANO; TORRES, MARIA FERNANDA PIOLI; KIRSCHNECK, CHRISTIAN. The role of postnatal estrogen deficiency on cranium dimensions. CLINICAL ORAL INVESTIGATIONS, v. 25, n. 5, p. 7-pg., 2020-10-25. (15/06866-5)

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KUCHLER, ERIKA CALVANO; MEGER, MICHELLE NASCIMENTO; OMORI, MARJORIE AYUMI; GERBER, JENNIFER TSI; MARTINS NETO, EVANDRO CARNEIRO; DA SILVA MACHADO, NILZA CRISTINA; CAVALCANTE, RAFAEL CORREA; TEIXEIRA, LUCAS RIBEIRO; STUANI, MARIA BERNADETE; NELSON FILHO, PAULO; et al. Association between oestrogen receptors and female temporomandibular disorders. ACTA ODONTOLOGICA SCANDINAVICA, v. 78, n. 3, p. 8-pg., 2019-10-18. (15/06866-5)