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Establishment and application of methodologies for optimizing imaging techniques in digital radiology


Diagnostic radiology has experienced remarkable advances in the last decades, with the development of digital image receptors. The migration of conventional to digital radiology is resulting of the advantages of digital detectors, resulting in a better image quality. However, optimization studies should be performed in order to identify conditions that provide the best image quality, while reducing the radiation dose absorbed by the patient. The main scope of this project is to establish a methodology for studying the optimal exposure parameters for different x-ray imaging examinations, through the implementation of a research laboratory of x-ray medical imaging and dosimetry. This project includes the optimization study of digital radiology, covering basically four different radiographic examinations: general digital radiology (chest radiography and orthopedic), digital mammography and pediatric radiology. In all cases, the dosimetric and image quality study will be performed by Monte Carlo simulation and experimentally. In clinical x-ray equipments, the method for optimization studies will be implemented and tested. This study will allow the identification of conditions that can improve the quality of the image obtained, and reducing risk to the patient's exposure to ionizing radiation. Besides, digital image receptors will be l characterized, in order to evaluate the most appropriate for each radiographic examination. Thus, this project is directly related to the research area of Radiation Physics and Dosimetry in Medical Physics. Besides, its development will contribute to the strengthening of Researches in medical physics developed at Applied Physics Department of the of Physics Gleb Wataghin of UNICAMP, especially the Medical Radiological Physics Group (GFRMd). (AU)

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Scientific publications (18)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, JOSILENE C.; TOMAL, ALESSANDRA; DE BARROS, NESTOR; COSTA, PAULO R.. Normalized glandular dose (DgN) coefficients from experimental mammographic x-ray spectra. Physics in Medicine and Biology, v. 64, n. 10, . (13/07117-0, 10/12237-7, 15/21873-8)
MAGALHAES, D. P.; RINKEL, J.; TOMAL, A.. Radiation damage impact on hybrid-pixel detectors data. Radiation Physics and Chemistry, v. 160, p. 63-67, . (15/21873-8, 11/51594-2)
ROSALES, LISET DE LA FUENTE; INCERTI, SEBASTIEN; FRANCIS, ZIAD; BERNAL, MARIO A.. Accounting for radiation-induced indirect damage on DNA with the Geant 4-DNA code. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, v. 51, p. 108-116, . (15/21873-8, 11/51594-2)
MASSERA, RODRIGO T.; TOMAL, ALESSANDRA. Breast glandularity and mean glandular dose assessment using a deep learning framework: Virtual patients study. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, v. 83, p. 264-277, . (15/21873-8)
FRANCIS, Z.; MONTAROU, G.; INCERTI, S.; BERNAL, M.; ZEIN, S. A.. A simulation study of gold nanoparticles localisation effects on radiation enhancement at the mitochondrion scale. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, v. 67, p. 148-154, . (11/51594-2, 18/15316-7, 15/21873-8)
MAGALHAES, D. P.; TOMAL, A.. Monte Carlo simulation of hybrid pixel detectors. Radiation Physics and Chemistry, v. 167, . (11/51594-2, 15/21873-8)
LI, WEI BO; STANGL, STEFAN; KLAPPROTH, ALEXANDER; SHEVTSOV, MAXIM; HERNANDEZ, ALICIA; KIMM, MELANIE A.; SCHUEMANN, JAN; QIU, RUI; MICHALKE, BERNHARD; BERNAL, MARIO A.; et al. Application of High-Z Gold Nanoparticles in Targeted Cancer Radiotherapy-Pharmacokinetic Modeling, Monte Carlo Simulation and Radiobiological Effect Modeling. CANCERS, v. 13, n. 21, . (15/21873-8, 20/08647-7, 11/51594-2, 18/15316-7)
MASSERA, RODRIGO T.; THOMSON, ROWAN M.; TOMAL, ALESSANDRA. Technical note: MC-GPU breast dosimetry validations with other Monte Carlo codes and phase space file implementation. Medical Physics, v. 49, n. 1, . (18/05982-0, 15/21873-8, 16/15366-9)
SHIN, WOOK-GEUN; SAKATA, DOUSATSU; LAMPE, NATHANAEL; BELOV, OLEG; TRAN, NGOC HOANG; PETROVIC, IVAN; RISTIC-FIRA, ALEKSANDRA; DORDEVIC, MILOS; BERNAL, MARIO A.; BORDAGE, MARIE-CLAUDE; et al. A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast. CANCERS, v. 13, n. 19, . (18/15316-7, 15/21873-8, 11/51594-2, 20/08647-7)
SANTOS, JOSILENE C.; TOMAL, ALESSANDRA; FURQUIM, TANIA A.; FAUSTO, AGNES M. F.; NOGUEIRA, MARIA S.; COSTA, PAULO R.. Direct measurement of clinical mammographic x-ray spectra using a CdTe spectrometer. Medical Physics, v. 44, n. 7, p. 3504-3511, . (13/07117-0, 15/21873-8, 10/12237-7)
MASSERA, RODRIGO TREVISAN; TOMAL, ALESSANDRA. Skin models and their impact on mean glandular dose in mammography. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, v. 51, p. 38-47, . (16/15366-9, 15/21873-8)
TREVISAN MASSERA, RODRIGO; TOMAL, ALESSANDRA. Estimation of glandular dose in mammography based on artificial neural networks. Physics in Medicine and Biology, v. 65, n. 9, . (16/15366-9, 15/21873-8)
BALLARINI, F.; CARANTE, M. P.; CAJIAO, J. J. TELLO; BERNAL, M. A.. Biophysical modelling of proximity effects in chromosome aberration production. NUOVO CIMENTO C-COLLOQUIA AND COMMUNICATIONS IN PHYSICS, v. 41, n. 6, . (11/51594-2, 15/21873-8)
SAKATA, DOUSATSU; LAMPE, NATHANAEL; KARAMITROS, MATHIEU; KYRIAKOU, IOANNA; BELOV, OLEG; BERNAL, MARIO A.; BOLST, DAVID; BORDAGE, MARIE-CLAUDE; BRETON, VINCENT; BROWN, JEREMY M. C.; et al. Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, v. 62, p. 152-157, . (15/21873-8, 11/51594-2)
TANG, NICOLAS; BUENO, MARTA; MEYLAN, SYLVAIN; PERROT, YANN; TRAN, HOANG N.; FRENEAU, AMELIE; DOS SANTOS, MORGANE; VAURIJOUX, AURELIE; GRUEL, GAETAN; BERNAL, MARIO A.; et al. Assessment of Radio-Induced Damage in Endothelial Cells Irradiated with 40 kVp, 220 kVp, and 4 MV X-rays by Means of Micro and Nanodosimetric Calculations. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 24, . (11/51594-2, 18/15316-7, 15/21873-8)
MASSERA, RODRIGO T.; FERNANDEZ-VAREA, JOSE M.; TOMAL, ALESSANDRA. Impact of photoelectric cross section data on systematic uncertainties for Monte Carlo breast dosimetry in mammography. Physics in Medicine and Biology, v. 66, n. 11, . (16/15366-9, 15/21873-8)
SENIWAL, BALJEET; BERNAL, MARIO A.; FONSECA, TELMA C. F.. Microdosimetric calculations for radionuclides emitting beta and alpha particles and Auger electrons. Applied Radiation and Isotopes, v. 166, . (18/15316-7, 15/21873-8, 11/51594-2)
ZABIHI, AZAM; TELLO, JOHN; INCERTI, SEBASTIEN; FRANCIS, ZIAD; FOROZANI, GHASEM; SEMSARHA, FARID; MOSLEHI, AMIR; BERNAL, MARIO A.. Determination of fast neutron RBE using a fully mechanistic computational model. Applied Radiation and Isotopes, v. 156, . (11/51594-2, 18/15316-7, 15/21873-8)

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