Abstract
New models of organization and health practices in Brazil are efforts to improve services and an approach based not only on the disease, but in the health-disease process aiming prevention and quality of life. The emphasis on healthy habits among the population is a milestone, increased motivation to adopt healthy habits, greater interest in having a healthy body, further knowledge on genetic determinants and the appreciation of the benefits of physical activity and exercise to the health and quality of life. The promotion of health has to find proposals to meet emerging issues in our society in a way that has an overview of "microdeterminants" and "macrodeterminants" of the health-disease process. To create new opportunities for health intervention is necessary in the ongoing effort to study the physiology of the human body along with the pursuit of thorough knowledge of the genotype and phenotype interaction. A major goal of human genetics is to understand how changes in the DNA of individuals provide the development of disease, and the biggest challenge is the search for correlations between genotype and phenotype. The approach for molecular genetic studies of complex phenotypes has evolved considerably during the past few years, the next-generation sequencing (NGS) has enabled great advances and contributed greatly to the evolution of medicine. The research in our group for several years has been concentrated on systems like kallikrein kinins and renin angiotensin, primarily using transgenic animals, enzyme kinetics and gene expression in general. All this history has brought us extensive experience in molecular biology. Along the years we have increased our knowledge on genetic diseases and also in the genotype phenotype correlation in physical activity and sports. The fundamental connection between all these projects is the need for deepening genetic studies to bring further progress in the area, since they are all "clinical challenges", due to their complexity or due to the mosaic of events that hinder the genotype and phenotype correlation. These studies are crucial to advances in screening and diagnosis, development of new therapeutic and preventive approaches, supporting quality of life, as well as in the quest for a healthy body. Thus we aimed to establish a center of genetic research, which will be a very important OMIC tool to assist in the conduct of "clinical challenges" as well as for physical and sport performance, representing a new benchmark for genetic and molecular studies in Brazil. (AU)
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