| Grant number: | 15/17329-0 |
| Support Opportunities: | Regular Research Grants |
| Start date: | May 01, 2016 |
| End date: | October 31, 2018 |
| Field of knowledge: | Biological Sciences - Pharmacology - Toxicology |
| Principal Investigator: | Camilo Dias Seabra Pereira |
| Grantee: | Camilo Dias Seabra Pereira |
| Host Institution: | Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil |
| City of the host institution: | Santos |
| Associated researchers: | Denis Moledo de Souza Abessa ; Eduardo Alves de Almeida ; Julián Blasco Moreno ; Luciane Alves Maranho ; Maria Laura Martin Diaz ; Tomas Angel Del Valls Casillas ; Wagner Vilegas |
Abstract
Illicit drugs have been considered as a growing social and public health problem worldwide. Millions of people have consumed these substances, which cocaine is among the most consumed one. The consumption and trafficking of cocaine in South America have become more prominent, particularly in Brazil. The main responsible for the discharge of emerging substances (such as illicit drugs) in the marine environment are the domestic wastewater through sewage outfalls. Based on past studies of our group that identified the presence of cocaine in surface water at the Bay of Santos and biological effects in environmentally relevant concentrations, it comes the need for the environmental risk of illicit drugs in coastal environments through a tiered methodology which contemplates quantification in environmental matrices (surface water and bioaccumulation in marine organisms) and ecotoxicological study using as a model a marine organism sentinel (Perna perna mussels). This proposal is concerning the first study on illicit drug concentrations in a subtropical marine ecosystem and also the first assessment of possible adverse effects caused by illegal drugs to marine biota, in Brazil and in the world. To achieve this goal, we proposed the quantification of cocaine in environmental samples in the laboratory, as well as evaluating the acute and chronic toxicity of crack cocaine in Perna perna mussels. This proposal aims to contribute to information about the biological effects to draw attention to this type of contamination, and to propose tools for future application in biomonitoring and environmental legislation. (AU)
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