Development of paper-based microfluidic devices for pharmaceuticas analysis in wastewaters.

• Grant number: 16/03369-3
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2016
• End date: May 31, 2018
• Field of knowledge: Engineering - Sanitary Engineering - Water Supply and Wastewater Treatment
• Principal Investigator: Paulo Clairmont Feitosa de Lima Gomes
• Grantee: Paulo Clairmont Feitosa de Lima Gomes
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated researchers: Arnaldo Alves Cardoso ; Arnaldo Sarti ; Wendell Karlos Tomazelli Coltro

Abstract

The growing demand of water forced to reduce its waste and input the need of re-use it. However, the occurrence of pharmaceuticals drugs in wastewaters are widely reported in last two decades which it is a concern based on the ecotoxicological effects confirmed to humans,aquatic fauna and flora. Thus, the development of analytical methods are essential in order tomonitor the presence of pharmaceuticals drugs in wastewaters. These methods are also necessary to evaluate the treatment applied in the wastewater treatment plants; moreover to supply studies involving the development of new wastewater treatment technologies. Then, this project aims to develop paper-based microfluidic microsystems (¼PADs) to analyze six pharmaceuticals drugs present wastewaters. ¼PADs using wax and toner as hydrophobic barriers and polymeric ¼PADs will be studied in this project. Colorimetric methods will be developed using scanner detection and cell phone cameras. Also, a mass spectrometry direct coupling will be studied using polymeric ¼PADs. Application of microfluidic microsystems using complex samples is scarce, mainly for monitoring of pharmaceuticals drugs in wastewaters. In this project, samples of lab-made sewage, anaerobic bioreactor affluent and effluent, domestic and hospital sewage will be analyzed. As future perspective is to develop a low cost, precise and accurate microfluidic microsystems to monitor pharmaceuticals drugs in wastewaters samples. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARASCO JUNIOR, CESAR AUGUSTO; DA SILVA, BIANCA FERREIRA; LAMARCA, RAFAELA SILVA; FEITOSA DE LIMA GOMES, PAULO CLAIRMONT. Automated method to determine pharmaceutical compounds in wastewater using on-line solid-phase extraction coupled to LC-MS/MS. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, JUN 2021. (18/11700-7, 16/03369-3, 14/50945-4, 18/22393-8)

LAMARCA, RAFAELA SILVA; LUCHIARI, NATALIA DA COSTA; BONJORNO, ANDRESSA FRANCIELLI; FILHO, JULIANO PASSARETTI; CARDOSO, ARNALDO ALVES; FEITOSA DE LIMA GOMES, PAULO CLAIRMONT. Determination of formaldehyde in cosmetic products using gas-diffusion microextraction coupled with a smartphone reader. ANALYTICAL METHODS, v. 11, n. 29, p. 3697-3705, AUG 7 2019. (16/03369-3)

MARASCO JUNIOR, CESAR A.; SARTORE, DOUGLAS M.; LAMARCA, RAFAELA S.; DA SILVA, BIANCA F.; SANTOS-NETO, ALVARO J.; GOMES, PAULO CLAIRMONT F. DE LIMA. On-line solid-phase extraction of pharmaceutical compounds from wastewater treatment plant samples using restricted access media in column-switching liquid chromatography-tandem mass spectrometry. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, v. 1180, AUG 15 2021. (18/22393-8, 18/11700-7, 16/03369-3, 14/50945-4)

MARASCO JUNIOR, CESAR AUGUSTO; DA SILVA, BIANCA FERREIRA; LAMARCA, RAFAELA SILVA; FEITOSA DE LIMA GOMES, PAULO CLAIRMONT. Automated method to determine pharmaceutical compounds in wastewater using on-line solid-phase extraction coupled to LC-MS/MS. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 413, n. 20, SI, p. 5147-5160, AUG 2021. (18/11700-7, 14/50945-4, 18/22393-8, 16/03369-3)

PASSARETTI FILHO, JULIANO; GOMES VALENTE JUNIOR, MARCO ANTONIO; DE LIMA GOMES, PAULO CLAIRMONT F.; FUGIVARA, CECILIO SADAO; CARDOSO, ARNALDO ALVES. Determination of Fe(III) using digital images: study of corrosion in steel plates using a polyester laser printed device. ANALYTICAL METHODS, v. 9, n. 4, p. 655-663, 2017. (15/23265-5, 16/03369-3)

LUCHIARI, NATALIA DA COSTA; DA SILVA, GABRIELEN ALVES; MARASCO JUNIOR, CESAR AUGUSTO; FEITOSA DE LIMA GOMES, PAULO CLAIRMONT. Development of miniaturized fluorimetric device for caffeine determination using a smartphone. RSC ADVANCES, v. 9, n. 60, p. 35033-35038, OCT 30 2019. (18/22393-8, 14/50945-4, 16/03369-3)

Filed patent(s) as a result of this research project