Advanced search
Start date

S-nitrosothiol containing nanoparticles: Synthesis, characterization, cytotoxicity and applications


The free radical nitric oxide (NO) plays a key role in several biological processes in mammals, such as the control of vasodilation, the immunological responses, the inhibition of platelet adhesion, the cell communication, and the wound healing. In addition, NO is recognized as important molecule in several physiologic process in plants, including break seed dormancy, stimulate plant germination and greening, control iron homeostasis in plants, and improve plant tolerance to salinity, metal toxicity, temperature and drought stress. As a free radical, NO donors are administrated in several applications. Among them, S-nitrosothiols (RSNOs) are an important class of NO donors, since they spontaneously decompose releasing NO, and this decomposition can be triggered by light irradiation (visible region). Several papers in the literature reveal that the combination of nanotechnology and RSNOs is a promising strategy to allow the therapeutic uses of NO. In this context, the main goal of this project is the synthesis and characterization of RSNOs containing (i) biocompatible polymeric based nanoparticles (poly(lactic-co-glycolic acid), quitosan and polycaprolactone); (ii) ferromagnetic nanoparticles (Fe3O4@quitosana). The kinetics of thermal and photochemical NO release from the synthesized nanoparticles and the cytotoxicity and mechanisms of toxicity will be evaluated. Moreover, the NO-releasing nanomaterials will be applied on plants under abiotic stresses. The project hopes to contribute to the design of biocompatible NO-releasing nanomaterials for biomedical and agriculture applications. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PELEGRINO, MILENA T.; PAGANOTTI, ANDRE; SEABRA, AMEDEA B.; WELLER, RICHARD B.. Photochemistry of nitric oxide andS-nitrosothiols in human skin. Histochemistry and Cell Biology, v. 153, n. 6, p. 431-441, . (17/05029-8, 16/10347-6)
PELEGRINO, MILENA T.; LIMA, BRUNA DE ARAUJO; DO NASCIMENTO, MONICA H. M.; LOMBELLO, CHRISTIANE B.; BROCCHI, MARCELO; SEABRA, AMEDEA B.. Biocompatible and Antibacterial Nitric Oxide-Releasing Pluronic F-127/Chitosan Hydrogel for Topical Applications. POLYMERS, v. 10, n. 4, . (17/05029-8, 16/10347-6)
PELEGRINO, MILENA T.; SILVA, LETECIA C.; WATASHI, CAROLINA M.; HADDAD, PAULA S.; RODRIGUES, TIAGO; SEABRA, AMEDEA B.. Nitric oxide-releasing nanoparticles: synthesis, characterization, and cytotoxicity to tumorigenic cells. JOURNAL OF NANOPARTICLE RESEARCH, v. 19, n. 2, . (14/13913-7, 15/00393-8, 16/10347-6)
PELEGRINO, M. T.; WELLER, R. B.; CHEN, X.; BERNARDES, J. S.; SEABRA, A. B.. Chitosan nanoparticles for nitric oxide delivery in human skin. MedChemComm, v. 8, n. 4, p. 713-719, . (15/00393-8, 16/10347-6)
SEABRA, AMEDEA B.; OLIVEIRA, HALLEY C.. How nitric oxide donors can protect plants in a changing environment: what we know so far and perspectives. AIMS MOLECULAR SCIENCE, v. 3, n. 4, p. 692-718, . (16/10347-6)
GONCALVES, L. C.; SEABRA, A. B.; PELEGRINO, M. T.; DE ARAUJO, D. R.; BERNARDES, J. S.; HADDAD, P. S.. Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications. RSC ADVANCES, v. 7, n. 24, p. 14496-14503, . (14/13913-7, 16/10347-6)
OLIVEIRA, HALLEY C.; GOMES, BRUNA C. R.; PELEGRINO, MILENA T.; SEABRA, AMEDEA B.. Nitric oxide-releasing chitosan nanoparticles alleviate the effects of salt stress in maize plants. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 61, p. 10-19, . (15/00393-8, 16/10347-6)
HADDAD, PAULA S.; SANTOS, MARCONI C.; DE GUZZI CASSAGO, CAROLINA APARECIDA; BERNARDES, JULIANA S.; DE JESUS, MARCELO BISPO; SEABRA, AMEDEA B.. Synthesis, characterization, and cytotoxicity of glutathione-PEG-iron oxide magnetic nanoparticles. JOURNAL OF NANOPARTICLE RESEARCH, v. 18, n. 12, . (14/13913-7, 16/10347-6)
ROLIM, WALLACE R.; PIERETTI, JOANA C.; RENO, DEBORA L. S.; LIMA, BRUNA A.; NASCIMENTO, MONICA H. M.; AMBROSIO, FELIPE N.; LOMBELLO, CHRISTIANE B.; BROCCHI, MARCELO; DE SOUZA, ANA CAROLINA S.; SEABRA, AMEDEA B.. Antimicrobial Activity and Cytotoxicity to Tumor Cells of Nitric Oxide Donor and Silver Nanoparticles Containing PVA/PEG Films for Topical Applications. ACS APPLIED MATERIALS & INTERFACES, v. 11, n. 6, p. 6589-6604, . (18/02832-7, 16/10347-6)
PELEGRINO, MILENA T.; DE ARAUJO, DANIELE R.; SEABRA, AMEDEA B.. S-nitrosoglutathione-containing chitosan nanoparticles dispersed in Pluronic F-127 hydrogel: Potential uses in topical applications. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 43, p. 211-220, . (14/13913-7, 15/00393-8, 16/10347-6)
PELEGRINO, MILENA T.; SEABRA, AMEDEA B.. Chitosan-Based Nanomaterials for Skin Regeneration. AIMS MEDICAL SCIENCE, v. 4, n. 3, p. 352-381, . (17/05029-8, 16/10347-6)
SILVEIRA, NEIDIQUELE M.; SEABRA, AMEDEA B.; MARCOS, FERNANDA C. C.; PELEGRINO, MILENA T.; MACHADO, EDUARDO C.; RIBEIRO, RAFAEL V.. Encapsulation of S-nitrosoglutathione into chitosan nanoparticles improves drought tolerance of sugarcane plants. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 84, p. 38-44, . (12/19167-0, 16/10347-6, 15/00393-8, 18/08194-2)
ROLIM, WALLACE R.; PELEGRINO, MILENA T.; LIMA, BRUNA DE ARAUJO; FERRAZ, LETICIA S.; COSTA, FANNY N.; BERNARDES, JULIANA S.; RODIGUES, TIAGO; BROCCHI, MARCELO; SEABRA, AMEDEA B.. Green tea extract mediated biogenic synthesis of silver nanoparticles: Characterization, cytotoxicity evaluation and antibacterial activity. Applied Surface Science, v. 463, p. 66-74, . (16/10347-6)

Please report errors in scientific publications list by writing to:
Filed patent(s) as a result of this research project

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação BR1020180002325 - Universidade Federal do ABC (UFABC) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - January 2018, 04

PROCESSOS DE APLICAÇÕES AGRÍCOLAS UTILIZANDO NANOPARTÍCULAS DOADORAS DE ÓXIDO NÍTRICO BR1020160290627 - Universidade Estadual de Londrina (UEL) ; Universidade Federal do ABC (UFABC) . Halley Caixeta de Oliveira; Amedea Barozzi Seabra; Bruna Cristina Rodrigues Gomes; Milena Trevisan Pelegrino - December 2016, 12