Genetics of erectile dysfunction: asymetrical dimethylarginine related genes affecting sildenafil responsiveness

• Grant number: 16/04449-0
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2016
• End date: July 31, 2018
• Field of knowledge: Biological Sciences - Pharmacology - Clinical Pharmacology
• Principal Investigator: Riccardo Lacchini
• Grantee: Riccardo Lacchini
• Host Institution: Escola de Enfermagem de Ribeirão Preto (EERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Emilio Hirsch ; Jose Eduardo Tanus dos Santos ; Silvio Tucci Junior

Abstract

Genetics of complex diseases and drug responses are the main targets of Pharmacogenetics. The idea is to try to determine the chances of a given person to develop a disease or not respond to common pharmacological treatments. Regarding erectile dysfunction, it has already been shown a close relationship between this disease, cardiovascular risk, and future cardiovascular-related death. The early diagnosis not only improves patient's life quality but also benefits patients as they tend to initiate early their cardiovascular treatments and postpone the onset of more serious cardiovascular diseases. Genetic and biochemical biomarkers that we investigate here may be beneficial at providing tools to early identify and diagnose these patients and provide better pharmacological treatment to their illness. This is a strictly observational case-control study. Will be included 100 patients with erectile dysfunction and 110 age, ethnicity, and body mass index paired healthy controls. Genomic DNA and plasma samples will be obtained in order to assess nitric oxide and cortisol pathways. Biochemical and genetic biomarkers will be evaluated regarding their association with disease risk and pharmacological response. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MILANEZ AZEVEDO, ANA MARIA; BRITES-ANSELMI, GUILHERMO; PINHEIRO, LUCAS CEZAR; BELO, VANESSA DE ALMEIDA; COELI-LACCHINI, FERNANDA BORCHERS; FERNANDES MOLINA, CARLOS AUGUSTO; DE ANDRADE, MURILO FERREIRA; TUCCI, JR., SILVIO; HIRSCH, EMILIO; TANUS-SANTOS, JOSE EDUARDO; et al. Relationship between asymmetric dimethylarginine, nitrite and genetic polymorphisms: Impact on erectile dysfunction therapy. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 71, p. 44-51, DEC 1 2017. (16/04449-0)

FEREZIN, LETICIA PERTICARRARA; KAYZUKA, CEZAR; PEREIRA, VITORIA CAROLINA RONDON; DE ANDRADE, MURILO FERREIRA; MOLINA, CARLOS AUGUSTO FERNANDES; TUCCI JR, SILVIO; TANUS-SANTOS, JOSE EDUARDO; LACCHINI, RICCARDO. The rs2682826 Polymorphism of the NOS1 Gene Is Associated with the Degree of Disability of Erectile Dysfunction. LIFE-BASEL, v. 13, n. 5, p. 13-pg., 2023-04-25. (20/11740-9, 16/04449-0, 18/18312-2)

BRITES-ANSELMI, GUILHERMO; MILANEZ AZEVEDO, ANA MARIA; LIMA MIYAZAKI, ANDERSON HEIJI; PINHEIRO, LUCAS CEZAR; COELI-LACCHIN, FERNANDA BORCHERS; DE ANDRADE, MURILO FERREIRA; FERNANDES MOLINA, CARLOS AUGUSTO; TUCCI, JR., SILVIO; HIRSCH, EMILIO; TANUS-SANTOS, JOSE EDUARDO; et al. DDAH1 and DDAH2 polymorphisms associate with asymmetrical dimethylarginine plasma levels in erectile dysfunction patients but not in healthy controls. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 92, p. 11-17, NOV 1 2019. (16/04449-0)

FIGARO-DRUMOND, FERNANDA VIANA; PEREIRA, SHERLIANE CARLA; MENEZES, ITIANA CASTRO; BAES, CRISTIANE VON WERNE; COELI-LACCHINI, FERNANDA BORCHERS; OLIVEIRA-PAULA, GUSTAVO HENRIQUE; CLEARE, ANTHONY J.; YOUNG, ALLAN H.; TANUS-SANTOS, JOSE EDUARDO; JURUENA, MARIO F.; et al. Association of 11 beta-hydroxysteroid dehydrogenase type1 (HSD11b1) gene polymorphisms with outcome of antidepressant therapy and suicide attempts. Behavioural Brain Research, v. 381, MAR 2 2020. (16/04449-0)