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Syngonanthus nitens Bong. (Rhul.)-loaded nanostructured system for vulvovaginal candidiasis treatment

Grant number: 16/13784-8
Support type:Regular Research Grants - Publications - Scientific article
Duration: August 01, 2016 - January 31, 2017
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Taís Maria Bauab
Grantee:Taís Maria Bauab
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Herbal-loaded drug delivery nanotechnological systems have been extensively studied recently. The antimicrobial activity of medicinal plants has shown better pharmacological action when such plants are loaded into a drug delivery system than when they are not loaded. Syngonanthus nitens Bong. (Rhul.) belongs to the Eriocaulaceae family and presents antiulcerogenic, antioxidant, antibacterial, and antifungal activity. The aim of this study was to evaluate the antifungal activity of S. nitens extract that was not loaded (E) or loaded (SE) into a liquid crystal precursor system (S) for the treatment of vulvovaginal candidiasis (VVC) with Candida albicans. The minimal inhibitory concentration (MIC) was determined by the microdilution technique. Additionally, we performed hyphae inhibition and biofilm tests. Finally, experimental candidiasis was evaluated in in vivo models with Wistar female rats. The results showed effective antifungal activity after incorporation into S for all strains tested, with MICs ranging from 31.2 µg/mL to 62.5µg/mL. Microscopic observation of SE revealed an absence of filamentous cells 24 hours of exposure to a concentration of 31.2 µg/mL. E demonstrated no effective action against biofilms, though SE showed inhibition against biofilms of all strains. In the in vivo experiment, SE was effective in the treatment of infection after only two days of treatment and was more effective than E and amphotericin B. The S. nitens is active against C. albicans and your antifungal potential was enhanced after incorporation into LCPS, these findings represents a promising application for SE in the treatment of VVC. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS RAMOS, MATHEUS APARECIDO; DE TOLEDO, LUCIANI GASPAR; FIORAMONTI CALIXTO, GIOVANA MARIA; BONIFACIO, BRUNA VIDAL; DE FREITAS ARAUJO, MARCELO GONZAGA; DOS SANTOS, LOURDES CAMPANER; GOTTARDO DE ALMEIDA, MARGARETE TERESA; CHORILLI, MARLUS; BAUAB, TAIS MARIA. Syngonanthus nitens Bong. (Rhul.)-Loaded Nanostructured System for Vulvovaginal Candidiasis Treatment. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 17, n. 8 AUG 2016. Web of Science Citations: 9.

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