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Development of healing pharmaceutical formulation containing bromelain extracted from industrial wastes

Grant number: 16/03444-5
Support type:Regular Research Grants
Duration: August 01, 2016 - March 31, 2019
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Priscila Gava Mazzola
Grantee:Priscila Gava Mazzola
Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Assoc. researchers:Janaína Artem Ataide ; Leticia Caramori Cefali

Abstract

Bromelain is a protease, obtained from different species from Bromeliaceae family, and it is present in the pineapple stem and fruit and is disposed in juice and jelly production. This biomolecule is known for its clinical and therapeutic applications, mainly the burn selective debridement, improvement of antibiotic and anti-inflammatory action, anti-thrombotic and fibrinolytic action. Its therapeutic potential is poorly explored due to its physical and chemical instability, which prevent to reach their full potential of action, once it easily denatures. Thereby, this projects aims bromelain encapsulation (micro and nano scale) using polymeric particles. the particulate systems are able to afford better stability, efficacy and safety for the encapsulated active and have attracted the pharmaceutical industry interest. After encapsulation process, the obtained particles will be characterized and will be evaluated its release profile, bromelain enzymatic activity, stability, in vitro pharmacological activity and toxicological profile. Then particles will be incorporated into semi-solid formulations for topical use. Those formulations will be evaluated according with pharmacopoeic requeriments. At this project end, it is intended to obtain a formulation containing bromelain, which attends the stability and therapeutic efficacy requirement for human use. (AU)

Articles published in Agência FAPESP about the research grant
Pineapple enzyme and bacterial nanocellulose make a powerful dressing for wounds 

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CROISFELT, FERNANDA MACHADO; TUNDISI, LOUISE LACALENDOLA; ATAIDE, JANAINA ARTEM; SILVEIRA, EDGAR; TAMBOURGI, ELIAS BASILE; JOZALA, ANGELA FAUSTINO; BARBOSA SOUTO, ELIANA MARIA; MAZZOLA, PRISCILA GAVA. Modified-release topical hydrogels: a ten-year review. Journal of Materials Science, v. 54, n. 16, p. 10963-10983, AUG 2019. Web of Science Citations: 0.
ATAIDE, JANAINA ARTEM; CEFALI, LETICIA CARAMORI; CROISFELT, FERNANDA MACHADO; MARTINS SHIMOJO, ANDREA ARRUDA; OLIVEIRA-NASCIMENTO, LAURA; MAZZOLA, PRISCILA GAVA. Natural actives for wound healing: A review. Phytotherapy Research, v. 32, n. 9, p. 1664-1674, SEP 2018. Web of Science Citations: 0.
CROISFELT, FERNANDA MACHADO; ATAIDE, JANAINA ARTEM; TUNDISI, LOUISE LACALENDOLA; CEFALI, LETICIA CARAMORI; REBELO, MARCIA DE ARAUJO; DAVILA SANCHEZ, JOSE LUIS; DA COSTA, TAIS GERMANO; LIMA, RENATA; JOZALA, ANGELA FAUSTINO; CHAUD, MARCO VINICIUS; D'AVILA, MARCOS AKIRA; TAMBOURGI, ELIAS BASILE; SILVEIRA, EDGAR; MAZZOLA, PRISCILA GAVA. Characterization of PNIPAAm-co-AAm hydrogels for modified release of bromelain. EUROPEAN POLYMER JOURNAL, v. 105, p. 48-54, AUG 2018. Web of Science Citations: 1.
ATAIDE, JANAINA ARTEM; GERIOS, ELOAH FAVERO; MAZZOLA, PRISCILA GAVA; SOUTO, ELIANA B. Bromelain-loaded nanoparticles: A comprehensive review of the state of the art. ADVANCES IN COLLOID AND INTERFACE SCIENCE, v. 254, p. 48-55, APR 2018. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
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