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Association study of clinical, functional and neuroimaging in women with migraine

Grant number: 15/18031-5
Support type:Research Projects - Thematic Grants
Duration: August 01, 2016 - July 31, 2021
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Débora Bevilaqua Grossi
Grantee:Débora Bevilaqua Grossi
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Co-Principal Investigators:Anamaria Siriani de Oliveira
Assoc. researchers: Camila de Giacomo Carneiro Barros ; César Fernandez de Las Penas ; Fabiola Dach ; Marcelo Eduardo Bigal ; Paolo Bonato ; Renato de Moraes
Associated scholarship(s):18/22999-3 - Noninvasive intracranial pressure monitoring in patients with chronic migraine, BP.PD
18/21687-8 - Craniocervical flexion test in women with migraine associated or not with cervical pain, BP.IC
18/23832-5 - Evaluation of the maximum strength and electromyographic activity of cervical musculature in patients with migraine and chronic migrane: controlled study, BP.PD
+ associated scholarships 18/21066-3 - Correlation between cutaneous allodynia and somatosensory cortex volume and thickness in patients with migraine, BP.IC
18/17783-1 - Evaluation of maximal strength and electromyographic activity of the cervical muscle in Migraine and Chronic Migraine: a cross-sectional study, BP.TT
17/20902-0 - Evaluation of static postural control with and without visual and sound disturbance in women with migraine, BP.IC
17/20711-0 - Comparing two methods of measuring cervical muscle strength, BP.IC
17/20839-6 - Influence evaluation of visual system on postural balance of women with migraine, BP.IC
17/07410-0 - Maximum strength and electromyographic activity evaluation of the cervical muscle in Migraine and Chronic Migraine: a control study, BP.PD
17/07482-1 - Computerized dynamic posturography of patients with Migraine, BP.PD - associated scholarships


The study of headache, particularly migraine in the field of physiotherapy, is an innovative theme, even more when associating clinical data typical from neurology and otoneurology clinical settings. Our group has studied musculoskeletal and functional consequences in these patients. There is, however, motor control adaptations and their relationship with clinical and structural aspects still unclear. The main objective of this project is to identify permanent adaptations in motor control of migraine patients and if theses adaptations distinct promotes functional impact. It will be assessed: 1) cervical motor control under maximal and submaximal conditions; 2) postural control and the contribution of vestibular, visual or proprioceptive systems to maintain it and, also the repercussion of external disturbance in the static and dynamic balance 3) to evaluate if there is a correlation of these functional and structural changes in the central nervous system or oculomotor and vestibular systems. Moreover, we intend to elucidate the the magnitude of the association among musculoskeletal variables or functional effects with the chronicity of migraine frequency. Therefore, it is being proposed three studies where women with migraine, will be divided according to the migraine subtype: migraine with aura, migraine without aura, chronic migraine and control subjects. The volunteers will undergo MRI examination and otoneurological exams. They will have their cervical spine motion, body posture, balance and adaptive locomotion assessed according to each study. Data from these studies will contribute to the knowledge of a proper multidisciplinary approach of the individual with migraine and their relationships with musculoskeletal and functional variables. They will also provide subsidies for the best clinical and functional kinetic of this condition also considering neurological and neurootological aspects. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Migraine is associated with pain in joint connecting jawbone to skull