Multi-user equipment (MUE) approved in Grant FAPESP project 2014/05151-0: inductively coupled plasma mass spectrometer hyphenated to an high performance liquid chromatography (HPLC-ICP-MS)

• Grant number: 16/10060-9
• Support Opportunities: Multi-user Equipment Program
• Start date: August 01, 2016
• End date: July 31, 2023
• Field of knowledge: Health Sciences - Pharmacy - Toxicological Analysis
• Principal Investigator: Bruno Lemos Batista
• Grantee: Bruno Lemos Batista
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Associated research grant: 14/05151-0 - Arsenic and rice: monitoring and (bio)remediation studies for food safety, AP.JP
• EMU web page: http://propes.ufabc.edu.br/cem/agendasa.html
• Type of equipment: Caracterização de Materiais - Análises Químicas - Cromatografia líquida acoplada a espectrômetro de massa
• Manufacturer: Agilent
• Model: 7900 ICP-MS

Abstract

Arsenic (As) is considered the most toxic xenobiotic according to the Agency for Toxic Substances and Disease Registry in the United States. Concerning the chemical species present in nature, inorganic As (As3+ and As5+) are the most toxic to humans and the methylated forms are less toxic (MMA - monomethyl As -, DMA - dimethyl As - and AsB - arsenobetaine) . When present in the soil, they are absorbed by the rice roots, reaching the grain. This cereal is an important food of Brazilians and almost half the world's population, therefore, a relevant route of exposure. One the one hand, the plant has mechanisms that favor the absorption of As by roots, especially As3+ when cultivated under flooded conditions. On the other hand, also has defense mechanisms such as phytochelatins and efflux of As. It is known that the rice consumed in Brazil has an average concentration of > 222 ng g-1 which about 60 % is inorganic, representing a risk to health when compared to the maximum tolerable value of 10 µg l-1 in potable water. The main producing states are Rio Grande do Sul and Santa Catarina, which uses the cultivation at flooded conditions. Furthermore, there is currently an intense discussion among participants of the Codex Alimentarius about the maximum levels of As in rice, as well as methods of speciation and practices to mitigate this contamination. Therefore, this project aims to develop methods of chemical speciation, risk assessment of the consumption of rice and its derivatives regarding As contamination, to investigate Brazilian cultivars in relation their predilection for As, development of method for trapping volatile As for evaluation of their presence in soils of rice paddies and, finally, to study mitigation through polishing, cooking and (bio)remediation using fungi isolated from the rhizosphere of Brazilian rice. Through this project we hope to evaluate the risk of rice consumption, to reduce the As contamination in the grains aggregating nutritional value and create human resources to work on chemical analysis and food safety. (AU)

Scientific publications

(21)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SEGURA, FABIANA ROBERTA; FRANCO, DANIEL FERNANDEZ; CENTENO DA SILVA, JULIO JOSE; BATISTA, BRUNO LEMOS. Variations in total As and As species in rice indicate the need for crop-tracking. Journal of Food Composition and Analysis, v. 86, MAR 2020. (15/06674-9, 16/10060-9, 14/05151-0)

SOUZA, FELIPE DE MOURA; PANIZ, FERNANDA POLLO; PEDRON, TATIANA; DOS SANTOS, MAURO COELHO; BATISTA, BRUNO LEMOS. A high-throughput analytical tool for quantification of 15 metallic nanoparticles supported on carbon black. HELIYON, v. 5, n. 3, MAR 2019. (17/22976-0, 16/19924-6, 17/10118-0, 16/10060-9, 14/05151-0, 18/06870-0, 17/21846-6)

LEROUX, ISABELLE NOGUEIRA; DA SILVA FERREIRA, ANA PAULA SACONE; PANIZ, FERNANDA POLLO; PEDRON, TATIANA; SALLES, FERNANDA JUNQUEIRA; DA SILVA, FABIO FERREIRA; MALTEZ, HELOISA FRANCA; BATISTA, BRUNO LEMOS; KANESHIRO OLYMPIO, KELLY POLIDO. Lead, Cadmium, and Arsenic Bioaccessibility of 24 h Duplicate Diet Ingested by Preschool Children Attending Day Care Centers in Brazil. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 15, n. 8, AUG 2018. (16/10060-9, 12/21840-4, 14/05151-0, 15/01395-4, 11/23272-0, 14/20945-2, 11/13076-0)

SOARES GUIMARAES, LEANDRO HENRIQUE; SEGURA, FABIANA ROBERTA; TONANI, LUDMILLA; VON-ZESKA-KRESS, MARCIA REGINA; RODRIGUES, JAIRO LISBOA; CALIXTO, LEANDRO AUGUSTO; SILVA, FABIO FERREIRA; BATISTA, BRUNO LEMOS. Arsenic volatilization by Aspergillus sp. and Penicillium sp. isolated from rice rhizosphere as a promising eco-safe tool for arsenic mitigation. Journal of Environmental Management, v. 237, p. 170-179, MAY 1 2019. (15/06674-9, 16/10060-9, 14/05151-0, 17/10104-9)

KOHATSU, MARCIO YUKIHIRO; PELEGRINO, MILENA TREVISAN; MONTEIRO, LUCILENA REBELO; FREIRE, BRUNA MOREIRA; PEREIRA, RODRIGO MENDES; FINCHEIRA, PAOLA; RUBILAR, OLGA; TORTELLA, GONZALO; BATISTA, BRUNO LEMOS; DE JESUS, TATIANE ARAUJO; et al. Comparison of foliar spray and soil irrigation of biogenic CuO nanoparticles (NPs) on elemental uptake and accumulation in lettuce. APL BIOENGINEERING, v. 5, n. 1, p. 16350-16367, MAR 1 2021. (19/26337-8, 16/10060-9, 17/05029-8, 17/20914-8, 18/08194-2)

KOHATSU, MARCIO YUKIHIRO; LANGE, CAMILA NEVES; PELEGRINO, MILENA TREVISAN; PIERETTI, JOANA CLAUDIO; TORTELLA, GONZALO; RUBILAR, OLGA; BATISTA, BRUNO LEMOS; SEABRA, AMEDEA BAROZZI; DE JESUS, TATIANE ARAUJO. Foliar spraying of biogenic CuO nanoparticles protects the defence system and photosynthetic pigments of lettuce (Lactuca sativa). JOURNAL OF CLEANER PRODUCTION, v. 324, NOV 15 2021. (19/26337-8, 17/20914-8, 17/05029-8, 21/00738-6, 18/08194-2, 16/10060-9)

FREIRE, BRUNA MOREIRA; PANIZ, FERNANDA POLLO; LANGE, CAMILA NEVES; PEDRON, TATIANA; DA SILVA, JAQUELINE TROMBETTA; SANCHEZ, FABIANA E SILVA; PARFITT, JOSE MARIA BARBAT; BATISTA, BRUNO LEMOS. Effect of water management on human exposure to inorganic arsenic and other trace elements through rice consumption. Journal of Food Composition and Analysis, v. 122, p. 11-pg., 2023-06-16. (22/04254-6, 14/05151-0, 16/10060-9, 16/19924-6, 20/00284-2)

VICTORIA FREITAS DE OLIVEIRA; EDUARDO VENSKE; CÁSSIA FERNANDA STAFEN; FERNANDA POLLO PANIZ; TATIANA PEDRON; RODRIGO MENDES PEREIRA; ARIANO MARTINS DE MAGALHÃES JÚNIOR; LUCIANO CARLOS DA MAIA; ANTONIO COSTA DE OLIVEIRA; BRUNO LEMOS BATISTA; et al. Associação genômica ampla para teor de ferro em grãos de arroz na região Sul do Brasil. Pesquisa Agropecuária Brasileira, v. 58, 2023-10-13. (16/10060-9, 14/05151-0)

FREIRE, BRUNA MOREIRA; LANGE, CAMILA NEVES; PEDRON, TATIANA; MONTEIRO, LUCILENA REBELO; SANCHES, LIVIA RENTAS; PEDREIRA-FILHO, WALTER DOS REIS; BATISTA, BRUNO LEMOS. Occupational exposure of foundry workers assessed by the urinary concentrations of 18 elements and arsenic species. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 62, DEC 2020. (14/05151-0, 16/10060-9, 17/20914-8)

FREIRE, BRUNA MOREIRA; GONZAGA, ROBERTA GRANJA; PEDRON, TATIANA; MONTEIRO, LUCILENA REBELO; LANGE, CAMILA NEVES; PEDREIRA FILHO, WALTER DOS REIS; BATISTA, BRUNO LEMOS. Occupational exposure to potentially toxic elements in the foundry industry: an integrated environmental and biological monitoring. Environmental Science and Pollution Research, v. 28, n. 26, SI, p. 34630-34641, JUL 2021. (16/19924-6, 17/20914-8, 20/00284-2, 16/10060-9, 14/05151-0)

KOHATSU, MARCIO YUKIHIRO; PELEGRINO, MILENA TREVISAN; MONTEIRO, LUCILENA REBELO; FREIRE, BRUNA MOREIRA; PEREIRA, RODRIGO MENDES; FINCHEIRA, PAOLA; RUBILAR, OLGA; TORTELLA, GONZALO; BATISTA, BRUNO LEMOS; DE JESUS, TATIANE ARAUJO; et al. Comparison of foliar spray and soil irrigation of biogenic CuO nanoparticles (NPs) on elemental uptake and accumulation in lettuce. Environmental Science and Pollution Research, v. 28, n. 13, p. 16350-16367, APR 2021. (17/05029-8, 19/26337-8, 16/10060-9, 17/20914-8, 18/08194-2)

DE OLIVEIRA MAXIMINO, JOSIANE VARGAS; BARROS, LILIAN MOREIRA; PEREIRA, RODRIGO MENDES; DE SANTI, IVANDRA IGNES; ARANHA, BIANCA CAMARGO; BUSANELLO, CARLOS; VIANA, VIVIAN EBELING; FREITAG, ROGERIO ANTONIO; BATISTA, BRUNO LEMOS; DE OLIVEIRA, ANTONIO COSTA; et al. Mineral and Fatty Acid Content Variation in White Oat Genotypes Grown in Brazil. BIOLOGICAL TRACE ELEMENT RESEARCH, v. 199, n. 3, p. 1194-1206, MAR 2021. (14/05151-0, 16/10060-9)

PEDRON, TATIANA; SEGURA, FABIANA ROBERTA; PANIZ, FERNANDA POLIO; SOUZ, FELIPE DE MOURA; DOS SANTOS, MAURO COELHO; DE MAGALHAES JUNIOR, ARIANO MARTINS; BATISTA, BRUNO LEMOS. Mitigation of arsenic in rice grains by polishing and washing: Evidencing the benefit and the cost. JOURNAL OF CEREAL SCIENCE, v. 87, p. 52-58, MAY 2019. (16/19924-6, 15/06674-9, 14/05151-0, 17/22976-0, 16/10060-9, 18/06870-0, 17/21846-6)

PANIZ, FERNANDA POLLO; PEDRON, TATIANA; FREIRE, BRUNA MOREIRA; TORRES, DAIANE PLACIDO; SILVA, FABIO FERREIRA; BATISTA, BRUNO LEMOS. Effective procedures for the determination of As, Cd, Cu, Fe, Hg, Mg, Mn, Ni, Pb, Se, Th, Zn, U and rare earth elements in plants and foodstuffs. ANALYTICAL METHODS, v. 10, n. 33, p. 4094-4103, SEP 7 2018. (16/19924-6, 14/05151-0, 16/10060-9, 18/06870-0)

PEDRON, TATIANA; FREIRE, BRUNA MOREIRA; CASTRO, CARLOS EDUARDO; RIBAL, LUIZ FELIPE; BATISTA, BRUNO LEMOS. Availability of arsenic in rice grains by in vitro and in vivo (humans) assays. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 56, p. 184-191, DEC 2019. (17/20914-8, 16/10060-9, 14/05151-0, 16/19924-6)

SACONE DA SILVA FERRREIRA, ANA PAULA; PEREIRA, ELIZEU CHIODI; SALLES, FERNANDA JUNQUEIRA; DA SILVA, FABIO FERREIRA; BATISTA, BRUNO LEMOS; HANDAKAS, EVANGELOS; KANESHIRO OLYMPIO, KELLY POLIDO. Home-based and informal work exposes the families to high levels of potentially toxic elements. Chemosphere, v. 218, p. 319-327, MAR 2019. (16/11087-8, 16/07457-4, 17/14392-9, 16/10060-9, 17/15797-2)

MALTZAHN, LATOIA EDUARDA; ZENKER, STEFANIA GARCIA; LOPES, JENNIFER LUZ; PEREIRA, RODRIGO MENDES; VERDI, CEZAR AUGUSTO; ROTHER, VIANEI; BUSANELLO, CARLOS; VIANA, VIVIAN EBELING; BATISTA, BRUNO LEMOS; DE OLIVEIRA, ANTONIO COSTA; et al. Brazilian Genetic Diversity for Desirable and Undesirable Elements in the Wheat Grain. BIOLOGICAL TRACE ELEMENT RESEARCH, v. 199, n. 6, AUG 2020. (14/05151-0, 16/10060-9)

DE OLIVEIRA, VICTORIA FREITAS; BUSANELLO, CARLOS; VIANA, VIVIAN EBELING; STAFEN, CASSIA FERNANDA; PEDROLO, ANA MARINA; PANIZ, FERNANDA POLLO; PEDRON, TATIANA; PEREIRA, RODRIGO MENDES; ROSA, SILVANA ALVES; DE MAGALHAES JUNIOR, ARIANO MARTINS; et al. Assessing mineral and toxic elements content in rice grains grown in southern Brazil. Journal of Food Composition and Analysis, v. 100, JUL 2021. (16/10060-9, 14/05151-0)

PEDRON, TATIANA; OLIVEIRA, GREIZIANY SOARES PAULINO; PANIZ, FERNANDA POLLO; SOUZA, FELIPE DE MOURA; MASUDA, HANA PAULA; DOS SANTOS, MAURO COELHO; ROCHA, BRUNO ALVES; PEREIRA, RODRIGO MENDES; BATISTA, BRUNO LEMOS. Determination of chemical elements in rice from Singapore markets: Distribution, estimated intake and differentiation of rice varieties. Journal of Food Composition and Analysis, v. 101, AUG 2021. (16/19924-6, 14/05151-0, 17/10118-0, 17/21846-6, 16/10060-9)

FREIRE, BRUNA MOREIRA; CAVALCANTI, YASMIN TAVARES; LANGE, CAMILA NEVES; PIERETTI, JOANA CLAUDIO; PEREIRA, RODRIGO MENDES; GONCALVES, MARCELLY CHUE; NAKAZATO, GERSON; SEABRA, AMEDEA BAROZZI; BATISTA, BRUNO LEMOS. Evaluation of collision/reaction gases in single-particle ICP-MS for sizing selenium nanoparticles and assessment of their antibacterial activity. Nanotechnology, v. 33, n. 35, p. 12-pg., 2022-08-27. (20/00284-2, 18/08194-2, 16/10060-9, 14/05151-0)

PEREIRA, ELIZEU CHIODI; LEROUX, ISABELLE NOGUEIRA; LUZ, MACIEL SANTOS; BATISTA, BRUNO LEMOS; KANESHIRO OLYMPIO, KELLY POLIDO. Study of controlled migration of cadmium and lead into foods from plastic utensils for children. Environmental Science and Pollution Research, v. N/A, p. 11-pg., 2022-03-11. (16/11087-8, 14/20945-2, 17/14392-9, 16/10060-9)