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Risedronate for osteoporosis treatment in patients with liver cirrhosis and esophageal varices: assessment on safety profile and bone mass

Grant number: 16/07117-9
Support type:Regular Research Grants
Duration: September 01, 2016 - August 31, 2018
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Fernando Gomes Romeiro
Grantee:Fernando Gomes Romeiro
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Osteoporosis is the only complication of liver cirrhosis that persists even after liver transplantation. It is a common complication among cirrhotic patients, increasing the risk of fractures and thus affecting morbidity and mortality rates. Early diagnosis and proper treatment are needed to avoid fractures and disability. The treatment requires nutritional supplementation of calcium and vitamin D combined with an anti-reabsortive drug as biphosphonates. In spite of the potential benefits that could be achieved by these drugs, oral biphosphonates can lead to upper digestive mucosal damage, which is a particular concern because cirrhotic patients often have esophageal varices. Therefore, the safety of this approach must be properly appraised in this population. In this study, the risk of upper digestive mucosal damage during oral risedronate treatment will be evaluated in cirrhotic patients who have esophageal varices and osteoporosis. The endoscopic findings will be evaluated through time, and the efficacy of this drug on bone mass will be also assessed. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROMEIRO, FERNANDO GOMES; IETSUGU, MARJORIE DO VAL; FRANZONI, LETICIA DE CAMPOS; AUGUSTI, LAIS; ALVAREZ, MATHEUS; AMARAL SANTOS, LIVIA ALVES; LIMA, TALLES BAZEI; KOGA, KATIA HIROMOTO; MORIGUCHI, SONIA MARTA; CARAMORI, CARLOS ANTONIO; SILVA, GIOVANNI FARI; GOMES GARCIA BETTING, LUIZ EDUARDO. Which of the branched-chain amino acids increases cerebral blood flow in hepatic encephalopathy? A double-blind randomized trial. NEUROIMAGE-CLINICAL, v. 19, p. 302-310, 2018. Web of Science Citations: 1.
AMARAL SANTOS, LIVIA ALVES; ROMEIRO, FERNANDO GOMES. Diagnosis and Management of Cirrhosis-Related Osteoporosis. BIOMED RESEARCH INTERNATIONAL, 2016. Web of Science Citations: 7.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.