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Strength training prevents hyperinsulinemia, insulin resistance, ánd inflammation independent of weight loss ín fructose-fed animals

Grant number: 16/14380-8
Support type:Regular Research Grants - Publications - Scientific article
Duration: September 01, 2016 - February 28, 2017
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:José Rodrigo Pauli
Grantee:José Rodrigo Pauli
Home Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil


The aim of this study was to compare the effects of aerobic, strength, and combined training on metabolic disorders induced by a fructose-rich diet. Wistar rats (120 days old) were randomized into five groups (n=8-14): C (control diet and sedentary), F (fed the fructose-rich diet and sedentary), FA (fed the fructose-rich diet and subject to aerobic exercise), FS (fed the fructose-rich diet and subject to strength exercise), and FAS (fed the fructose-rich diet and subject to combined aerobic and strength exercises). After the 8-week experiment, glucose homeostasis, blood biochemistry, tissue triglycerides, and inflammation were evaluated and analyzed. The strength protocol exerted greater effects on glucose homeostasis, insulin sensitivity, and liver lipid contents than other protocols (all P<0.05). All three exercise protocols induced a remarkable reduction in inflammation, tissue triglyceride content, and inflammatory pathways, which was achieved through c-Jun NH2-terminal kinase (JNK) phosphorylation and factor nuclear kappa B (NFkB) activation in both the liver and the muscle. Our data suggest that strength training reduced the severity of most of the metabolic disorders induced by a fructose-rich diet and could be the most effective strategy to prevent or treat fructose-induced metabolic diseases. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BOTEZELLI, JOSE D.; COOPE, ANDRESSA; GHEZZI, ANA C.; CAMBRI, LUCIELI T.; MOURA, LEANDRO P.; SCARIOT, PEDRO P. M.; GASPAR, RODRIGO STELLZER; MEKARY, RANIA A.; ROPELLE, EDUARDO ROCHETE; PAULI, JOSE RODRIGO. Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals. SCIENTIFIC REPORTS, v. 6, AUG 4 2016. Web of Science Citations: 16.

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