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Investigation for production of biodegradable carriers for natural larvicidals against Aedes aegypti

Grant number: 16/09824-4
Support Opportunities:Regular Research Grants
Duration: September 01, 2016 - August 31, 2018
Field of knowledge:Health Sciences - Collective Health - Epidemiology
Principal Investigator:Ana Silvia Prata
Grantee:Ana Silvia Prata
Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated researchers: Johan Bernard Ubbink ; Jose Roberto Trigo ; Julian Martínez ; Maria Teresa Pedrosa Silva Clerici ; Rodney Alexandre Ferreira Rodrigues


Many insecticides and repellents synthetics commercially available and considered by the population as the only effective way to control insects, are usually toxic, non-specific and pollutants, causing damage to the health of humans and to the ecosystem. The spread of dengue across the country is also a consequence of the non-selectivity of chemical insecticides and the resistance presented by the Aedes aegypti to these insecticides. There are many organic bioactive compounds produced by plants, potential for mosquito control, but they are inefficient when applied freely due to evaporation or leaching of active molecules, which results in reduced duration of insecticide / larvicide effect. Despite widespread public concern about environmental and health effects by the use of synthetic pesticides, natural pesticides must topple as commercially viable alternatives for reduced risk products. To overcome the instability of natural products, microencapsulation techniques have been used in different areas. Microencapsulation protects sensitive materials that can suffer degradation, enables the application in defined doses without direct contact with the active compound and can promote the controlled and gradual release of the active component. The objective of this project is to produce biodegradable carriers for controlled release of natural larvicides in a domestic environment. The prioritized technique aims to further industrial production of these carriers for allowing natural products be transformed into viable alternatives using low cost materials and with no risk of toxicity to the consumer and the environment. The development of these carriers is seen as a auxiliar measure for controlling the growth of larvae of Aedes aegypti, the vector of dengue, chickungunha and Zika virus. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MAIA, JULIANA DIAS; SCHMIELE, MARCIO; UBBINK, JOB; PRATA, ANA SILVIA. Biodegradable starch particles for controlled release applications: Swelling and leaching mechanisms. Journal of Applied Polymer Science, v. 137, n. 34, . (16/09824-4)
RAMOS, FERNANDA DE MELO; SILVEIRA JUNIOR, VIVALDO; PRATA, ANA SILVIA. Physical aspects of orange essential oil-contaning particles after vacuum spray drying processing. FOOD CHEMISTRY-X, v. 12, . (16/09824-4)
GONCALVES, NATHALIA D.; DUARTE, MARTA C. T.; PRATA, ANA S.; RODRIGUES, RODNEY A. F.. Antimicrobial Activity of Cashew Gum-Gelatin Coacervates as a Food Ingredient. ACS AGRICULTURAL SCIENCE & TECHNOLOGY, v. 1, n. 6, p. 9-pg., . (16/09824-4)
MAIA, JULIANA DIAS; LA CORTE, ROSELI; MARTINEZ, JULIAN; UBBINK, JOHAN; PRATA, ANA SILVIA. Improved activity of thyme essential oil (Thymus vulgaris) against Aedes aegypti larvae using a biodegradable controlled release system. INDUSTRIAL CROPS AND PRODUCTS, v. 136, p. 110-120, . (16/09824-4)
SILVA, GEZAILDO SANTOS; GOMES, MATHEUS HENRIQUE GOUVEIA; DE CARVALHO, LEILA MOREIRA; ABREU, THAIANALY LEITE; LIMA, MARCOS DOS SANTOS; MADRUGA, MARTA SUELY; KUROZAWA, LOUISE EMY; BEZERRA, TALIANA KENIA ALENCAR. Microencapsulation of organic coffee husk polyphenols: Effects on release, bioaccessibility, and antioxidant capacity of phenolics in a simulated gastrointestinal tract. Food Chemistry, v. 434, p. 10-pg., . (11/04230-5, 16/09824-4)

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Filed patent(s) as a result of this research project


PARTÍCULA BIODEGRADÁVEL E USO PCT/BR2018/0000072 - Universidade Estadual de Campinas (UNICAMP) . MAIA, Juliana Dias ; PRATA, Ana Silvia ; UBBINK, Johan Bernard ; SCHMIELE, Marcio - December 2018, 07