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Clinical and molecular aspects of antigens and antibodies of blood cells

Abstract

Red cell alloantibodies may cause hemolytic disease of the newborn and hemolytic transfusion reactions, while red cell autoantibodies participate in the immune destruction of red cells seen in autoimmune hemolytic anemia. Neutrophil alloantibodies may produce neonatal alloimune neutropenia and transfusion related acute lung injuri (TRALI), on the other hand granulocyte autoantibodies provoke neutrophil immune destruction observed in patients with autoimmune neutropenia. Platelet alloantibodies may induce neonatal alloimmune thrombocytopenia, post-transfusion purpura, and platelet transfusion refractoriness, conversely platelet autoantibodies induce primary or secondary immune thrombocytopenia purpura. The aim pf the present immunohematological project is to examine not only the molecular basis of the blood cells alloantigen systems, but also calculate the risk associated to the exposition to allogenic blood cells by blood component transfusion, transplantation, or pregnancy. The major project consists of 5 subprojects designed to study blood group systems: 1 subproject connected to platelet alloantigen systems; and 6 subprojects associated with granulocyte alloantigen systems. We propose to study immune mechanisms which take place in autoimmune hemolytic anemia, in homolysis post-kidney transplant, and in vaso-oclusive crisis seen in patients with sickle cell disease. We will also investigate molecular aspects of the Rh blood group system in brazilian individuals, the gene frequency of some platelet alloantigen systems, and the platelet alloimmunization risk in Brazilian ethnic groups. Finally, we will determine the phenotypic and genotypic distribution of the granulocyte alloantigen systems in different brazilian ethnic groups, the relevance of some polimorphisms in the expression of such antigens, and the role of granulocyte specific alloantibodies in some transfusion reactions. (AU)

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Scientific publications (12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BOTURAO-NETO, EDMIR; YAMAMOTO, MIHOKO; CHIBA, AKEMI KURODA; SUGANO KIMURA, ELISA YURIKO; VALGUEIRO COSTA DE OLIVEIRA, MARIA DO CARMO; DO MONTE BARRETTO, CLAUDIA LUMACK; ALVES NUNES, MERCIA MARIA; LOPES ALBUQUERQUE, SERGIO ROBERTO; DE DEUS SANTOS, MARCOS DANIEL; BORDIN, JOSE ORLANDO. Molecular Basis of KELnull Phenotype in Brazilians. TRANSFUSION MEDICINE AND HEMOTHERAPY, v. 42, n. 1, p. 52-58, 2015. Web of Science Citations: 2.
D'ABRONZO, L. S.; BARROS, M. M. O.; BORDIN, J. O.; FIGUEIREDO, M. S. Analysis of polymorphisms of TNF-alpha, LT-alpha, IL-10, IL-12 and CTLA-4 in patients with warm autoimmune haemolytic anaemia. INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, v. 34, n. 4, p. 356-361, AUG 2012. Web of Science Citations: 1.
CRUZ, B. R.; CHIBA, A. K.; MORITZ, E.; BORDIN, J. O. RHD alleles in Brazilian blood donors with weak D or D-negative phenotypes. Transfusion Medicine, v. 22, n. 2, p. 84-89, APR 2012. Web of Science Citations: 23.
TERZIAN, CLAUDIA C. N.; CHIBA, AKEMI K.; SANTOS, VIVIANI C.; SILVA, NEUSA P.; BORDIN, JOSE O. FCGR3B{*}03 allele inheritance pattern in Brazilian families and some new variants of gene FCGR3B. Transfusion, v. 52, n. 3, p. 629-634, MAR 2012. Web of Science Citations: 4.
LOPES, LARISSA B.; FABRON-, JR., ANTONIO; CHIBA, AKEMI K.; RUIZ, MARCELO O.; BORDIN, JOSE O. Impact of using different laboratory assays to detect human leukocyte antigen antibodies in female blood donors. Transfusion, v. 50, n. 4, p. 902-908, APR 2010. Web of Science Citations: 13.
MORITZ, E.; CHIBA, A. K.; KIMURA, E. Y.; ALBUQUERQUE, D.; GUIRAO, F. P.; YAMAMOTO, M.; COSTA, F. F.; BORDIN, J. O. Molecular studies reveal that A134T, G156A and G1333A SNPs in the CD177 gene are associated with atypical expression of human neutrophil antigen-2. Vox Sanguinis, v. 98, n. 2, p. 160-166, FEB 2010. Web of Science Citations: 18.
NORCIA, A. M. M. I.; SUGANO, E. Y. K.; CHIBA, A. K.; MORITZ, E.; GUIRAO, F. P.; YAMAMOTO, M.; BORDIN, J. O. Human neutrophil alloantigen-1a,-1b,-2,-3a and-4a frequencies in Brazilians. TISSUE ANTIGENS, v. 74, n. 5, p. 404-407, NOV 2009. Web of Science Citations: 10.
MORITZ, ELYSE; NORCIA, ANGELA M. M. I.; CARDONE, JOSE D. B.; KUWANO, SACHIE T.; CHIBA, AKEMI K.; YAMAMOTO, MIHOKO; BORDIN, JOSE O. Human neutrophil alloantigens systems. Anais da Academia Brasileira de Ciências, v. 81, n. 3, p. 559-569, SEP 2009. Web of Science Citations: 23.
BARROS, MELCA M. O.; YAMAMOTO, MIHOKO; FIGUEIREDO, MARIA S.; CANCADO, RODOLFO; KIMURA, ELISA Y. S.; LANGHI, JR., DANTE M.; CHIATTONE, CARLOS S.; BORDIN, JOSE O. Expression levels of CD47, CD35, CD55, and CD59 on red blood cells and signal-regulatory protein-alpha,beta on monocytes from patients with warm autoimmune hemolytic anemia. Transfusion, v. 49, n. 1, p. 154-160, JAN 2009. Web of Science Citations: 22.
BOTURÃO-NETO, EDMIR; CHIBA, AKEMI K.; VICARI, PERLA; FIGUEIREDO, MARIA S.; BORDIN, JOSÉ O. Molecular studies reveal a concordant KEL genotyping between patients with hemoglobinopathies and blood donors in São Paulo City, Brazil. Haematologica, v. 93, n. 9, p. 1408-1410, Sept. 2008.
FABRON JÚNIOR, ANTONIO; LOPES, LARISSA BARBOSA; BORDIN, JOSÉ ORLANDO. Lesão pulmonar aguda associada à transfusão. Jornal Brasileiro de Pneumologia, v. 33, n. 2, p. 206-212, 2007.
CARDONE‚ J.D.B.; BORDIN‚ J.O.; CHIBA‚ A.K.; NORCIA‚ A.M.M.I.; VIEIRA-FILHO‚ J.P.B. Gene frequencies of the HNA-4a and-5a neutrophil antigens in Brazilian persons and a new polymerase chain reaction-restriction fragment length polymorphism method for HNA-5a genotyping. Transfusion, v. 46, n. 9, p. 1515-1520, 2006.

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