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First Report of the Globally Disseminated IncX4 Plasmid Carrying the mcr-1 Gene in a Colistin-Resistant Escherichia coli ST101 isolated from a Human Infection in Brazil


A colistin-resistant Escherichia coli was recovered from a patient with a diabetic foot infection in Brazil. Whole genome analysis revealed that the E. coli isolate belonged to the widespread MLST sequence type ST101, harboring the mcr-1 gene onto an IncX4 plasmid, highly similar to IncX4 plasmids bearing mcr-1 recently identified in Enterobacteriaceae from food, animal and human samples recovered in different continents. These results suggest that self-transmissible IncX4-type plasmids may represent promiscuous plasmids contributing to the intercontinental spread of the mcr-1 gene. (AU)

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