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First report of the globally disseminated IncX4 plasmid carrying the MCR-1 gene in a Colistin-Resistant Escherichia coli ST101 isolated from a human infection in Brazil

Grant number: 16/16810-0
Support type:Regular Research Grants - Publications - Scientific article
Duration: September 01, 2016 - February 28, 2017
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Nilton Erbet Lincopan Huenuman
Grantee:Nilton Erbet Lincopan Huenuman
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


A colistin-resistant Escherichia coli was recovered from a patient with a diabetic foot infection in Brazil. Whole genome analysis revealed that the E. coli isolate belonged to the widespread MLST sequence type ST101, harboring the mcr-1 gene onto an IncX4 plasmid, highly similar to IncX4 plasmids bearing mcr-1 recently identified in Enterobacteriaceae from food, animal and human samples recovered in different continents. These results suggest that self-transmissible IncX4-type plasmids may represent promiscuous plasmids contributing to the intercontinental spread of the mcr-1 gene. (AU)