MEMBRANES OF NATURAL POLYMERS WITH ACTIVE COMPOUNDS FOR APPLICATION AS HIGH PERFORMANCE WOUND DRESSINGS

• Grant number: 16/17555-3
• Support Opportunities: Regular Research Grants
• Duration: November 01, 2016 - October 31, 2018
• Field of knowledge: Engineering - Chemical Engineering
• Principal Investigator: Mariana Agostini de Moraes
• Grantee: Mariana Agostini de Moraes
• Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil
• Associated researchers: Classius Ferreira da Silva ; Patricia Santos Lopes

Abstract

Healing of chronic wounds is still a medicine challenge, since these processes require a long healing time and, in some cases, can present complications, resulting in amputation. The development of dressings that promote a fast healing, avoid infections and provide adequate moisture, minimizing patient pain, is necessary. Furthermore, the incorporation of active compounds that promote a fast healing and that present analgesic and anti-inflammatory effect directly in the wound is even more interesting. In this project, we propose the development of membranes of natural polymers, in its pure form or in multilayers, that can act as controlled delivery devices and that can help in wound healing. From the scientific point of view, it will be studied the process of membrane preparation, the interactions among polymers (chitosan, alginate and fibroin) and the model drug (diclofenac sodium) influence on physical, chemical and biological properties of the membranes, as well as the kinetic study and the mechanisms involved on the release of drugs. It is expected to develop platforms to act in the controlled release of drugs in high performance wound dressings. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PACHECO, MURILO SANTOS; KANO, GUSTAVO EIJI; PAULO, LETICIA DE ALMEIDA; LOPES, PATRICIA SANTOS; DE MORAES, MARIANA AGOSTINI. Silk fibroin/chitosan/alginate multilayer membranes as a system for controlled drug release in wound healing. International Journal of Biological Macromolecules, v. 152, p. 803-811, JUN 1 2020. (16/17555-3, 17/20274-9)

PACHECO, MURILO SANTOS; SILVA, THAIS BELARMINO DA; TOMODA, BRUNO THORIHARA; MORAES, MARIANA AGOSTINI DE. Evaluation of diclofenac sodium incorporation in alginate membranes as potential drug release system. MATERIALIA, v. 12, AUG 2020. (16/17555-3)

TOMODA, BRUNO THORIHARA; CORAZZA, FULVIO GABRIEL; BEPPU, MARISA MASUMI; LOPES, PATRICIA SANTOS; DE MORAES, MARIANA AGOSTINI. Silk fibroin membranes with self-assembled globular structures for controlled drug release. Journal of Applied Polymer Science, v. 137, n. 16, DEC 2019. (16/17555-3)

BERTOLINI NETO, JOSE ARMANDO; DOS REIS, LUISA STORELLI; TOMODA, BRUNO THORIHARA; DE MORAES, MARIANA AGOSTINI. Combinatorial effect of pH and ionic strength in the release of charged dyes from silk fibroin membranes. MRS COMMUNICATIONS, v. 12, n. 4, p. 6-pg., 2022-06-29. (16/17555-3)