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Involvement of t cells and astrocytes of subnucleus caudalis in the inflammatory hipernociception induced by arthritis in the temporomandibular joint of rats

Grant number: 16/16529-9
Support type:Regular Research Grants
Duration: November 01, 2016 - October 31, 2018
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Principal Investigator:Juliana Trindade Clemente Napimoga
Grantee:Juliana Trindade Clemente Napimoga
Home Institution: Centro de Pesquisas Odontológicas São Leopoldo Mandic. Faculdade São Leopoldo Mandic (SLMANDIC). Sociedade Regional de Ensino e Saúde S/S Ltda (SRES). Campinas , SP, Brazil
Assoc. researchers:Cristina Gomes de Macedo Maganin ; Elizabeth Ferreira Martinez ; Marcelo Henrique Napimoga


Rheumatoid arthritis (RA) is an autoimmune polyarthritis resulting in a systemic condition of chronic inflammation affecting synovial joints and the temporomandibular joint (TMJ), the main complaint of pain patients. It was demonstrated that peripheral injuries resulted from albumin-induced arthritis in the TMJ of rats promote the activation of microglial cells in the trigeminal subnucleus caudalis through the release of Cathepsin S and Fractalkine associated with increased P2X7 receptor expression. The literature has been shown that the immune cells in the central nervous system - glial cells, endothelial cells, perivascular macrophages and T cells - have a key role in the modulation of neural transmission involving painful conditions. Thus, considering that activation of microglial cells is associated with induction and persistence of arthritis-induced inflammatory hypernociception in the TMJ of rats, it is possible to suggest that T cells and astrocytes from trigeminal subnucleus caudalis are activate by the microglial cells resulting in the persistence and chronicity of hipernociception induced by arthritis in the TMJ. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BONFANTE, RICARDO; NAPIMOGA, MARCELO HENRIQUE; MACEDO, CRISTINA GOMES; ADBALLA, HENRIQUE BALLASSINI; PIERONI, VICTOR; CLEMENTE-NAPIMOGA, JULIANA TRINDADE. The P2X7 Receptor, Cathepsin S and Fractalkine in the Trigeminal Subnucleus Caudalis Signal Persistent Hypernociception in Temporomandibular Rat Joints. Neuroscience, v. 391, p. 120-130, NOV 1 2018. Web of Science Citations: 4.

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