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Involvement of T cells and astrocytes of subnucleus caudalis in the inflammatory hipernociception induced by arthritis in the temporomandibular joint of rats.


Rheumatoid arthritis (RA) is an autoimmune polyarthritis resulting in a systemic condition of chronic inflammation affecting synovial joints and the temporomandibular joint (TMJ), the main complaint of pain patients. It was demonstrated that peripheral injuries resulted from albumin-induced arthritis in the TMJ of rats promote the activation of microglial cells in the trigeminal subnucleus caudalis through the release of Cathepsin S and Fractalkine associated with increased P2X7 receptor expression. The literature has been shown that the immune cells in the central nervous system - glial cells, endothelial cells, perivascular macrophages and T cells - have a key role in the modulation of neural transmission involving painful conditions. Thus, considering that activation of microglial cells is associated with induction and persistence of arthritis-induced inflammatory hypernociception in the TMJ of rats, it is possible to suggest that T cells and astrocytes from trigeminal subnucleus caudalis are activate by the microglial cells resulting in the persistence and chronicity of hipernociception induced by arthritis in the TMJ. (AU)

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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ABDALLA, HENRIQUE BALLASSINI; NAPIMOGA, MARCELO HENRIQUE; LOPES, ALEXANDRE HASHIMOTO; DE MACEDO MAGANIN, ALEXANDRE GOMES; CUNHA, THIAGO MATTAR; VAN DYKE, THOMAS E.; CLEMENTE NAPIMOGA, JULIANA TRINDADE. Activation of PPAR-gamma induces macrophage polarization and reduces neutrophil migration mediated by heme oxygenase 1. International Immunopharmacology, v. 84, . (16/16529-9)
BONFANTE, RICARDO; NAPIMOGA, MARCELO HENRIQUE; MACEDO, CRISTINA GOMES; ADBALLA, HENRIQUE BALLASSINI; PIERONI, VICTOR; CLEMENTE-NAPIMOGA, JULIANA TRINDADE. The P2X7 Receptor, Cathepsin S and Fractalkine in the Trigeminal Subnucleus Caudalis Signal Persistent Hypernociception in Temporomandibular Rat Joints. Neuroscience, v. 391, p. 120-130, . (16/16529-9, 14/09975-7, 11/00683-5, 11/18951-6)

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