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MicroRNAs, extracellular vesicles and stem cells: physiology, pathophysiological role and therapeutic potential in renal diseases


Regenerative medicine, defines a new concept related to strategies to restore damaged tissue or accelerate tissue repair after injury. The tissue reconstruction and repair, however, constitute a major challenge of the current biomedical research since the cellular mechanisms underlying tissue reconstruction and repair are still poorly understood and largely unknown. Multipotent stem cells, in spite of the regenerative potential, exert their effects through paracrine activity and their plasticity has not yet been proven in vivo. In this context, microRNAs originated from stem cells emerge as potential candidates involved in the regenerative processes, mainly due to their ability to modulate the activity of a number of genes including those responsible for tissue repair 1. MicroRNAs are found in body fluids including blood and urina 2. Which circulate widely within the extracellular vesicles (exosomes and microvesicles) 3. The biological function of microRNAs goes, however, beyond the regenerative processes being also related to many physiological and pathophysiological mechanisms such as cell-cell communication, interaction between microenvironments and communication between tissues and organ systems. Besides microRNAs, extracellular vesicles derived or not from stem cells carry many information that are transmitted to other cells 4. And therefore dysregulated or aberrant expression of miRNAs has significant role in the pathophysiology of several diseases including renal diseases. Thus, the main objective of this project is to evaluate potential roles of microRNAs and extracellular vesicles derived or not from stem cells in the physiology, pathophysiology and in the regenerative mechanisms of the kidney. (AU)

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Scientific publications (11)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RAFAEL DA SILVA LUIZ; RODOLFO ROSSETO RAMPASO; ALEF ARAGÃO CARNEIRO DOS SANTOS; MARCIA BASTOS CONVENTO; DULCE APARECIDA BARBOSA; CASSIANE DEZOTI DA FONSECA; ANDRÉIA SILVA DE OLIVEIRA; AGNALDO CAIRES; ANDREI FURLAN; NESTOR SCHOR; et al. BM-MSC-derived small extracellular vesicles (sEV) from trained animals presented nephroprotective potential in unilateralureteral obstruction model. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 27, . (15/23345-9)
HOSNI, NICOLE DITTRICH; ANAUATE, ANA CAROLINA; BOIM, MIRIAN APARECIDA. Reference genes for mesangial cell and podocyte qPCR gene expression studies under high-glucose and renin-angiotensin-system blocker conditions. PLoS One, v. 16, n. 7, . (15/23345-9)
DA-SILVA, CAROLINA CARVALHO SERRES; ANAUATE, ANA CAROLINA; GUIRAO, TATIANA PINOTTI; NOVAES, ANTONIO DA SILVA; MAQUIGUSSA, EDGAR; BOIM, MIRIAN APARECIDA. Analysis of exosome-derived microRNAs as early biomarkers of lipopolysaccharide-induced acute kidney injury in rats. FRONTIERS IN PHYSIOLOGY, v. 13, p. 10-pg., . (15/23345-9)
NOVAES, ANTONIO DA SILVA; BORGES, FERNANDA TEIXEIRA; MAQUIGUSSA, EDGAR; VARELA, VANESSA ARAUJO; SALLES DIAS, MARCOS VINICIOS; BOIM, MIRIAN APARECIDA. Influence of high glucose on mesangial cell-derived exosome composition, secretion and cell communication. SCIENTIFIC REPORTS, v. 9, . (15/23345-9, 17/00250-8)
DOS SANTOS BRONEL, BRUNO ARISTIDES; ANAUATE, ANA CAROLINA; MAQUIGUSSA, EDGAR; BOIM, MIRIAN APARECIDA; NOVAES, ANTONIO DA SILVA. Determination of reference genes as a quantitative standard for gene expression analysis in mouse mesangial cells stimulated with TGF-beta. SCIENTIFIC REPORTS, v. 12, n. 1, p. 10-pg., . (15/23345-9)
MUNOZ, J. J.; ANAUATE, A. C.; AMARAL, A. G.; FERREIRA, F. M.; MECA, R.; ORMANJI, M. S.; BOIM, M. A.; ONUCHIC, L. F.; HEILBERG, I. P.. Identification of housekeeping genes for microRNA expression analysis in kidney tissues of Pkd1 deficient mouse models. SCIENTIFIC REPORTS, v. 10, n. 1, . (15/17152-3, 11/21593-4, 18/09135-0, 15/23345-9)
MUNOZ, JUAN J.; ANAUATE, ANA C.; AMARAL, ANDRESSA G.; FERREIRA, FREDERICO M.; WATANABE, ELIESER H.; MECA, RENATA; ORMANJI, MILENE S.; BOIM, MIRIAN A.; ONUCHIC, LUIZ F.; HEILBERG, ITA P.. Ppia is the most stable housekeeping gene for qRT-PCR normalization in kidneys of three Pkd1-deficient mouse models. SCIENTIFIC REPORTS, v. 11, n. 1, . (15/17152-3, 11/21593-4, 18/09135-0, 15/23345-9)
FACIOLI, ROBERTA; LOJUDICE, FERNANDO HENRIQUE; ANAUATE, ANA CAROLINA; MAQUIGUSSA, EDGAR; NISHIURA, JOSE LUIZ; HEILBERG, ITA PFEFERMAN; SOGAYAR, MARI CLEIDE; BOIM, MIRIAN APARECIDA. Kidney organoids generated from erythroid progenitors cells of patients with autosomal dominant polycystic kidney disease. PLoS One, v. 16, n. 8, . (16/05311-2, 15/23345-9)
ISHIY, CRYSTHIANE SAVERIANO RUBIAO ANDRE; ORMANJI, MILENE SUBTIL; MAQUIGUSSA, EDGAR; RIBEIRO, ROSEMARA SILVA; DA SILVA NOVAES, ANTONIO; BOIM, MIRIAN APARECIDA. Comparison of the Effects of Mesenchymal Stem Cells with Their Extracellular Vesicles on the Treatment of Kidney Damage Induced by Chronic Renal Artery Stenosis. STEM CELLS INTERNATIONAL, v. 2020, . (15/23345-9)
GATTAI, PEDRO PAULO; MAQUIGUSSA, EDGAR; NOVAES, ANTONIO DA SILVA; RIBEIRO, ROSEMARA DA SILVA; VARELA, VANESSA ARAUJO; ORMANJI, MILENE SUBTIL; BOIM, MIRIAN APARECIDA. miR-26a modulates HGF and STAT3 effects on the kidney repair process in a glycerol-induced AKI model in rats. Journal of Cellular Biochemistry, v. 119, n. 9, p. 7757-7766, . (15/23345-9)
LUIZ, RAFAEL DA SILVA; RAMPASO, RODOLFO ROSSETO; CARNEIRO DOS SANTOS, ALEF ARAGAO; CONVENTO, MARCIA BASTOS; BARBOSA, DULCE APARECIDA; DA FONSECA, CASSIANE DEZOTI; DE OLIVEIRA, ANDREIA SILVA; CAIRES, AGNALDO; FURLAN, ANDREI; SCHOR, NESTOR; et al. M-MSC-derived small extracellular vesicles (sEV) from trained animals presented nephroprotective potential in unilateralureteral obstruction mode. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 27, . (15/23345-9)

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