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In vitro and in vivo characterization of calcium aluminate cement-based blends for application in the repair and regeneration of bone tissue

Grant number: 16/15032-3
Support type:Regular Research Grants
Duration: November 01, 2016 - October 31, 2018
Field of knowledge:Engineering - Materials and Metallurgical Engineering
Principal Investigator:Ivone Regina de Oliveira
Grantee:Ivone Regina de Oliveira
Home Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil
Assoc. researchers:Larissa Moreira Spinola de Castro Raucci ; Luana Marotta Reis de Vasconcellos ; Paulo Tambasco de Oliveira

Abstract

Ca-aluminate as a biomaterial has been evaluated for over two decades with regard to general physical, mechanical, and biocompatible properties. Due to its unique curing/hardening characteristics and related microstructure, Ca-aluminate based materials exhibit a great potential in the biomaterial field. An overview of the use of Ca-aluminate as a biomaterial in odontology and orthopaedics was already published. Aluminate cements are used as dental restorative materials and in orthopedics for repairing bone flaws based on their composition and thermal expansion coeficient, which are very similar to that of bones and teeth. The researcher responsible for this project has contributed to these studies through the development of approved projects FAPESP (2009/17451-0; 2013/22502-8); patent granted (PI0704502-6) "aluminous cement-based composition for application in Endodontics and cementitious product obtained thereof"; and technical articles. CAC-blends containing 4 wt% of different compounds (alumina, zirconia, zinc oxide, tricalcium phosphate and hydroxyapatite) resulted in samples with similar or higher mechanical strength than PMMA. SEM results showed that precipitation of hydroxyapatite occurred on blends but not on PMMA and the CAC-ZnO-Bi2O3 (15:10 wt%) composition presented suitable values of radiopacity. Blends with collagen, zinc oxide and zirconia presented cell viability similar to control. Studies about CAC-10 wt% CaCl2 (CAC+) supported the acquisition of the osteogenic cell phenotype in vitro, rendering this novel material a potential alternative in endodontic procedures. However, further in vivo studies are needed to verify if the beneficial in vitro effects of CAC+ on osteoblastic cells correspond to an increase and/or acceleration of bone repair in the periapical region. Within this context, this project proposes to continue these studies through complementary physical and chemical testing, in vitro and in vivo assays that still are needed for evaluation as CAC-base compositions efficiency in the repair and regeneration of bone tissue compared to PMMA. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SALOMAO, RAFAEL; FERREIRA, VERIDIANA LOPES; COSTA, LIGIA M. M.; DE OLIVEIRA, IVONE REGINA. Effects of the initial CaO-Al2O3 ratio on the microstructure development and mechanical properties of porous calcium hexaluminate. CERAMICS INTERNATIONAL, v. 44, n. 2, p. 2626-2631, FEB 1 2018. Web of Science Citations: 3.
Improving the Radiopacity of Calcium Aluminate Cement Based Blends. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, n. ahead, p. -, 2018.
DE OLIVEIRA, IVONE REGINA; VIEIRA, GABRIELA DO VALE; DOS SANTOS, KENNEDY WALLACE; RANIERO, LEANDRO JOSE; CASTRO-RAUCCI, LARISSA MOREIRA; DE OLIVEIRA, PAULO TAMBASCO; FORNARI, CELSO ISRAEL; PANDOLFELLI, VICTOR CARLOS. Improving the Radiopacity of Calcium Aluminate Cement Based Blends. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 21, n. 2, p. -, 2018. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
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