Early aging in people living with HIV/AIDS: pathophysiology, comorbidities and the interference of antiretrovirals

• Grant number: 16/15440-4
• Support Opportunities: Regular Research Grants
• Duration: December 01, 2016 - November 30, 2018
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Lenice Do Rosário de Souza
• Grantee: Lenice Do Rosário de Souza
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The combination of different drugs in highly active antiretroviral therapy (HAART), completely changed the scenario of the epidemic of HIV / AIDS, dramatically reducing the morbidity and mortality of people living with HIV (PLWHA). Despite the many benefits of starting ART, its prolonged use and early initiation has been much discussed throughout the world. Analyzing the cause of the current PLWHA deaths, it appears that, unlike the pre-HAART era, opportunistic infections constitute only a small portion, highlighting nowadays typical diseases of aging, such as cardiovascular diseases, renal disorders, bone and metabolic disorders, diabetes, cancers unrelated to AIDS, among others. Such chronic diseases, very common in the elderly general population, not only happen earlier in PLWHA, but also in larger numbers and some concomitantly. In this context, new challenges are present. Thus, our proposal is to study some common comorbidities in PLWHA, such as chronic kidney disease, risk of cardiovascular events and bone changes and risk of fractures, and associate them to the time of use of ART and its compliance rate. In addition, another purpose of this project is to analyze which factors may be related to the development of these diseases, such as inflammatory mechanisms, microbial translocation and oxidative stress. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CAMARGO, CAIO C.; CAVASSAN, NAYARA R. V.; TASCA, KAREN I.; MENEGUIN, SILMARA; MIOT, HELIO A.; SOUZA, LENICE R.. Depression and Coping Are Associated with Failure of Adherence to Antiretroviral Therapy Among People Living with HIV/AIDS. AIDS Research and Human Retroviruses, v. 35, n. 11-12, p. 1181-1188, NOV 1 2019. (16/15440-4)