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Development of innovative analytical methods for analytes of pharmaceutical interest based on ultra-high supercritical fluid chromatography associated with chemometrics tools

Abstract

Ultra High Performance Supercritical Fluid Chromatography (UHPSFC) is a new analytical technique that began to emerge since the worldwide launch of the first commercial equipment in 2012. Considering that the mobile phase is formed by the sub/supercritical CO2 associated with small quantities of organic solvents, this technique can be considered an unification of liquid and gas chromatography. The low viscosity of the mobile phase and high diffusivity of the analytes allow to achieve similar chromatographic efficiency as gas chromatography while the presence of organic modifiers of different polarities ensures the high selectivity reached in the liquid chromatography. Due to the possibility of changing the polarity of the mobile phase, it becomes possible to use different stationary phases ranging from bare silica used in normal-phase liquid chromatography to nonpolar phase used in reverse phase liquid chromatography. All these factors together make the technique extremely promising for analyzing a wide range of compounds. This project aims to evaluate this innovative technique for the development of faster, efficient and low-solvent consumption analytical methods for pharmaceutical compounds with different physical-chemical characteristics and high economic relevance belonging to the classes of statins, beta-blockers and vitamins, both hydrophilic and lipophilic. Multivariate methods of design of experiments (DOE) and optimization will be associated with the analytical development in order to better comprehend the retention mechanisms involved in this technique. (AU)

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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTANA, IGOR MIRANDA; JARDIM, ISABEL CRISTINA SALES FONTES; BREITKREITZ, MARCIA CRISTINA. Sequential design of experiments approach for the multiproduct analysis of cholesterol-lowering drugs by ultra-high-performance supercritical fluid chromatography. JOURNAL OF SEPARATION SCIENCE, . (16/05636-9)
MITSUTAKE, HERY; CASTRO, SIMONE R.; DE PAULA, ENEIDA; POPPI, RONEI J.; RUTLEDGE, DOUGLAS N.; BREITKREITZ, MARCIA C.. Comparison of different chemometric methods to extract chemical and physical information from Raman images of homogeneous and heterogeneous semi-solid pharmaceutical formulations. International Journal of Pharmaceutics, v. 552, n. 1-2, p. 119-129, . (16/05636-9, 14/50867-3)
REZENDE, CAMILA A.; ATTA, BEATRIZ W.; BREITKREITZ, MARCIA C.; SIMISTER, RACHAEL; GOMEZ, LEONARDO D.; MCQUEEN-MASON, SIMON J.. Optimization of biomass pretreatments using fractional factorial experimental design. BIOTECHNOLOGY FOR BIOFUELS, v. 11, . (16/10955-6, 16/05636-9, 16/13602-7)
GALAVERNA, RENAN; BREITKREITZ, MARCIA C.; PASTRE, JULIO C.. Conversion of D-Fructose to 5-(Hydroxymethyl)furfural: Evaluating Batch and Continuous Flow Conditions by Design of Experiments and In-Line FTIR Monitoring. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, v. 6, n. 3, p. 4220-4230, . (14/26378-2, 16/05636-9, 14/25770-6, 06/57897-9, 13/07607-8)
SANTANA, IGOR MIRANDA; BREITKREITZ, MARCIA C.; PINTO, LICARION. Multivariate Curve Resolution Alternating Least Squares Applied to Chromatographic Data: From the Basics to the Recent Advances. BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY, v. 8, n. 32, p. 22-44, . (16/05636-9)
PINTO, LICARION; SALES FONTES JARDIM, ISABEL CRISTINA; RUTLEDGE, DOUGLAS NEIL; BREITKREITZ, MARCIA CRISTINA. Multiblock modelling on the study of the kinetic degradation of rosuvastatin calcium in the presence of retention time shifts and rank deficiency. Analytica Chimica Acta, v. 1133, p. 77-87, . (14/50867-3, 16/05636-9)
DE LIMA, KAREN PRISCILA; SALES FONTES JARDIM, ISABEL CRISTINA; BREITKREITZ, MARCIA CRISTINA. Study of the chromatographic parameters of ultra-high-performance supercritical fluid chromatography and method development using a design of experiments approach for the quantification of pesticides in lettuce. JOURNAL OF SEPARATION SCIENCE, v. 41, n. 16, . (16/05636-9)
MITSUTAKE, HERY; RODRIGUES DA SILVA, GUSTAVO HENRIQUE; DE MORALS RIBEIRO, LIGIA NUNES; DE PAULA, ENEIDA; POPPI, RONEI J.; RUTLEDGE, DOUGLAS N.; BREITKREITZ, ARCIA C.. Raman Imaging and Chemometrics Evaluation of Natural and Synthetic Beeswaxes as Matrices for Nanostructured Lipid Carriers Development. BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY, v. 8, n. 32, p. 116-130, . (16/05636-9)

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