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Cancer and heart: new paradigms of diagnosis and treatment

Grant number: 15/22814-5
Support type:Research Projects - Thematic Grants
Duration: November 01, 2016 - October 31, 2021
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Carlos Eduardo Negrão
Grantee:Carlos Eduardo Negrão
Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Co-Principal Investigators:Anamaria Aranha Camargo ; Edilamar Menezes de Oliveira ; Ludhmila Abrahão Hajjar ; Maria Janieire de Nazaré Nunes Alves ; Maria Urbana Pinto Brandão Rondon ; Patricia Chakur Brum ; Paulo Marcelo Gehm Hoff ; Roberto Kalil Filho ; Roger Chammas
Assoc. researchers:Christina May Moran de Brito ; Fátima Solange Pasini ; Gilberto de Castro Junior ; Julio Cesar Batista Ferreira ; Luciana Nogueira de Sousa Andrade ; Luiz Fernando Lima Reis ; Maria Cristina Rodrigues Rangel ; Marília Harumi Higuchi dos Santos ; Marisa Passarelli ; Paula Fontes Asprino ; Paulo Rizzo Ramires ; Renata de Freitas Saito ; Silvia Moreira Ayub Ferreira ; Tatiane Katsue Furuya
Associated grant(s):18/22579-4 - Exosomal microRNAs as circulating biomarkers and mediators of the cardioprotective effect in patients undergoing cancer therapies, AP.R SPRINT
17/18081-8 - AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications, AR.EXT
17/08548-6 - Autophagy: from molecular principles to human diseases, AR.EXT
17/50029-6 - The use if RNA-based nano formulations to improve the efficacy of breast cancer treatment and reduce therapy-induced cardiotoxicity, AP.R SPRINT
16/50336-3 - Predicting survival in non-small-cell lung cancer: a link between cancer cachexia, cardiorespiratory fitness and cancer immune surveillance?, AP.R SPRINT
Associated scholarship(s):18/14491-0 - Role of aldehydes metabolism in the doxorubicin-induced cardiomyopathy: preventive and therapeutic effects of Alda-1, BP.PD
17/22069-3 - The role of MicroRNA-33a and sirtuine protein 6 in the metabolism and progression of Colon Cancer in mummy submitted to aerobic physical training, BP.DR
17/13133-0 - Relative role of physical activity on mitochondrial density and bioenergetics of infiltrating T lymphocytes from tumor microenvironment, BP.PD
+ associated scholarships 16/26169-0 - Potential therapeutic targets induced by aerobic exercise training for the treatment of cancer cachexia: a study of ribosomal proteins, BP.PD
16/22835-5 - Effects of voluntary physical activity on cardiac function and structure in animal models of cancer cachexia, BP.MS
15/09919-2 - Circulating miRNAs as biomarkers of cardiotoxicity and therapeutic potential in breast cancer, BP.PD
15/05427-8 - Impact of adjuvant chemotherapy in autonomic cardiovascular regulation in patients with colon cancer, BP.PD
14/11671-6 - Effect of high intensity interval training versus continuous moderate in the peripheral reflex mechanisms of control of the sympathetic activity in patients with heart failure, BP.PD
13/15651-7 - Effects of Aerobic Exercise Training Associated with Inspiratory Muscle Training on Skeletal Myopathy in Patients with Heart Failure, BP.PD
13/07651-7 - Prognostic value of the oscillatory pattern of muscle sympathetic nerve activity in patients with heart failure, BP.PD - associated scholarships

Abstract

Despite of the uninterrupted development of new medications for the treatment of cancer, the survival rate continues low especially in those patients in the advanced stage of the disease. Recent observations show that new therapeutics increase the susceptibility for cardiovascular diseases, which turns out to be the treatment of cancer even more complex. Cardiac dysfunction due to cardiotoxicity has been found in 10-15% breast cancer patients submitted to chemotherapy. Cardiac alterations associated with autonomicdysfunction have been recently documented in patients submitted to radiotherapy for treatment of lymphoma. Body weight gain, insulin resistance and hyperglycemia, dyslipidemia, and high blood pressure are very frequent in patients submitted to androgenic blockade or orquiectomy for the treatment of prostate adenocarcinoma. Therefore, the search for new treatments for cancer and elimination of collateral events caused by medications are great challenge in nowadays.Physical inactivity is very common in oncological patients. The debilitation due to the disease, treatment and demotivation contribute to the low level of physical activity in patients with cancer. On the other hand, studies involving large number of individual are unanimous in demonstrating the significant association between physical fitness and survival rate regardless of diseases. This knowledge suggests that exercise training may be an adjuvant strategy in the treatment of cancer. In fact, recent studies demonstrate that exercise training improves physical capacity and quality of life in patients suffering of cancer.The aim of our investigation is to search the molecular and autonomic mechanisms involved in the cardiovascular alterations provoked by cancer or chemotherapy and radiotherapy used in the treatment of this disease. Not less important will be the studies focused on the new therapeutic paradigms based on cellular and molecular principles, medications and exercise training for the treatment of cardiovascular diseases associated with cancer with special attention in the cardiac and skeletal toxicity.To accomplish these goals, 21 studies will be conducted in three areas: Cardio/Oncology, Oncologye Cardiology. (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre o auxílio:
Laboratory infrastructure in the state of São Paulo forms COVID-19 diagnostic testing platform 
Articles published in other media outlets (30 total):
More itemsLess items
UOL: Exercício reverte atrofia muscular por câncer e pode aumentar sobrevida (09/Sep/2020)
MSN: Quem enfrenta o câncer não deve ficar parado (27/Oct/2020)
Noticias RTV (Espanha): Quien se enfrenta al cáncer no debe quedarse quieto (27/Oct/2020)
Veja Saúde online: Quem enfrenta o câncer não deve ficar parado (27/Oct/2020)
Portal de Notícias: Aumentar a expressão de uma enzima produzida no músculo pode ser estratégia para combater atrofia (07/Oct/2020)
Portal da Enfermagem: Aumentar a expressão de uma enzima produzida no músculo pode ser estratégia para combater a atrofia (07/Oct/2020)
Veja Saúde: Quem enfrenta o câncer não deve ficar parado (01/Oct/2020)
Algomais online: Exercício físico reverte atrofia muscular provocada por câncer (15/Sep/2020)
BandMulti: Exercício físico reverte atrofia muscular causada por câncer e pode aumentar sobrevida (13/Sep/2020)
Jornal de Piracicaba: Exercício físico reverte atrofia muscular causada por Câncer pode aumentar sobrevida (12/Sep/2020)
Folha de Itapetininga: Exercício físico reverte atrofia muscular causada por câncer e pode aumentar sobrevida (12/Sep/2020)
Duna Press : SP: Exercício físico reverte atrofia muscular causada por câncer e pode aumentar sobrevida (11/Sep/2020)
Região Noroeste : Exercício físico reverte atrofia muscular causada por câncer (10/Sep/2020)
Dom Total: Praticar exercício físico reverte atrofia muscular causada por câncer, diz estudo (10/Sep/2020)
Ata News: Exercício físico reverte atrofia muscular causada por câncer e pode aumentar sobrevida (10/Sep/2020)
GR Notícias: Exercício físico reverte atrofia muscular causada por câncer e pode aumentar sobrevida (10/Sep/2020)
Jornal Folha da Terra (Itupeva, SP) online: Exercício físico reverte atrofia muscular causada por câncer e pode aumentar sobrevida (10/Sep/2020)
Rápido no Ar: Exercício físico reverte atrofia muscular causada por câncer e pode aumentar sobrevida (10/Sep/2020)
Beto Ribeiro Repórter: Exercício físico reverte atrofia muscular causada por câncer e pode aumentar sobrevida (10/Sep/2020)
Portal do Governo do Estado de São Paulo: Exercício físico reverte atrofia muscular causada por câncer e pode aumentar sobrevida (09/Sep/2020)
Espaço Ecológico no Ar: Exercício físico reverte atrofia muscular provocada por câncer e pode aumentar sobrevida de pacientes (09/Sep/2020)
Itaporã News: Exercício físico reverte atrofia muscular e prolonga sobrevida em casos de câncer (09/Sep/2020)
Blog Jornal da Mulher: Exercício físico reverte atrofia muscular provocada por câncer e pode aumentar sobrevida de pacientes (09/Sep/2020)
Revista Pará: Exercício físico reverte atrofia muscular provocada por câncer e pode aumentar sobrevida de pacientes (09/Sep/2020)
Bahia.ba: Exercício físico reverte atrofia muscular provocada por câncer e pode aumentar sobrevida (09/Sep/2020)
Comando Notícia: Exercício físico reverte atrofia muscular causada por câncer e pode aumentar sobrevida (09/Sep/2020)
Portal da Enfermagem: Exercício reverte atrofia muscular provocada por câncer e pode aumentar sobrevida (09/Sep/2020)
Mundo e Meio: Exercício físico reverte atrofia muscular provocada por câncer e pode aumentar sobrevida de paciente (09/Sep/2020)
Coluna Supinando: Exercício físico reverte atrofia muscular provocada por câncer (09/Sep/2020)
Paraíba Notícia: Exercício físico reverte atrofia muscular provocada por câncer e pode aumentar sobrevida de pacientes (09/Sep/2020)

Scientific publications (18)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALVES, CHRISTIANO R. R.; NEVES, WILLIAN DAS; ALMEIDA, NEY R. DE; EICHELBERGER, ERIC J.; JANNIG, PAULO R.; VOLTARELLI, VANESSA A.; TOBIAS, GABRIEL C.; BECHARA, LUIZ R. G.; FARIA, DANIELE DE PAULA; ALVES, MARIA J. N.; HAGEN, LARS; SHARMA, ANIMESH; SLUPPHAUG, GEIR; MOREIRA, JOSE B. N.; WISLOFF, ULRIK; HIRSHMAN, MICHAEL F.; NEGRAO, CARLOS E.; CASTRO, JR., GILBERTO DE; CHAMMAS, ROGER; SWOBODA, KATHRYN J.; RUAS, JORGE L.; GOODYEAR, LAURIE J.; BRUM, PATRICIA C. Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/ TRIP15/ALIEN. MOLECULAR METABOLISM, v. 39, SEP 2020. Web of Science Citations: 0.
GROEHS, RAPHAELA V.; NEGRAO, MARCELO V.; HAJJAR, LUDHMILA A.; JORDAO, CAMILA P.; CARVALHO, BRUNA P.; TOSCHI-DIAS, EDGAR; ANDRADE, ANA C.; HODAS, FABIANA P.; ALVES, MARIA J. N. N.; SARMENTO, ADRIANA O.; TESTA, LAURA; HOFF, PAULO M. G.; NEGRAO, CARLOS E.; KALIL FILHO, ROBERTO. Adjuvant Treatment with5-Fluorouraciland Oxaliplatin Does Not Influence Cardiac Function, Neurovascular Control, and Physical Capacity in Patients with Colon Cancer. ONCOLOGIST, AUG 2020. Web of Science Citations: 0.
PEIXOTO DA FONSECA, GUILHERME WESLEY; MACEDO, TANIA GARFIAS; EBNER, NICOLE; DOS SANTOS, MARCELO RODRIGUES; DE SOUZA, FRANCIS RIBEIRO; MADY, CHARLES; TAKAYAMA, LILIAM; RODRIGUES PEREIRA, ROSA MARIA; DOEHNER, WOLFRAM; ANKER, STEFAN D.; NEGRAO, CARLOS EDUARDO; DE NAZARE NUNES ALVES, MARIA JANIEIRE; VON HAEHLING, STEPHAN. Ms, muscle strength, and functional capacity in patients with heart failure of Chagas disease and other aetiologies. ESC HEART FAILURE, AUG 2020. Web of Science Citations: 0.
DOS SANTOS, MARCELO RODRIGUES; PEIXOTO DA FONSECA, GUILHERME WESLEY; SHERVENINAS, LETICIA PIRONATO; DE SOUZA, FRANCIS RIBEIRO; BATTAGLIA FILHO, ANTONIO CARLOS; NOVAES, CAIO EDUARDO; RODRIGUES PEREIRA, ROSA MARIA; NEGRAO, CARLOS EDUARDO; PEREIRA BARRETTO, ANTONIO CARLOS; DE NAZARE NUNES ALVES, MARIA-JANIEIRE. Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure. ESC HEART FAILURE, v. 7, n. 3 MAR 2020. Web of Science Citations: 0.
FONSECA, G. W. P. D.; DOS SANTOS, MARCELO RODRIGUES; DE SOUZA, FRANCIS RIBEIRO; TAKAYAMA, LILIAM; RODRIGUES PEREIRA, ROSA MARIA; NEGRAO, CARLOS EDUARDO; NUNES ALVES, MARIA-JANIEIRE DE NAZARE. Discriminating sarcopenia in overweight/obese male patients with heart failure: the influence of body mass index. ESC HEART FAILURE, v. 7, n. 1 DEC 2019. Web of Science Citations: 0.
ANTUNES-CORREA, LIGIA M.; TREVIZAN, PATRICIA F.; BACURAU, ALINE V. N.; FERREIRA-SANTOS, LARISSA; GOMES, JOAO L. P.; URIAS, URSULA; OLIVEIRA, PATRICIA A.; ALVES, MARIA JANIEIRE N. N.; DE ALMEIDA, DIRCEU R.; BRUM, PATRICIA C.; OLIVEIRA, EDILAMAR M.; HAJJAR, LUDHMILA; KALIL FILHO, ROBERTO; NEGRAO, CARLOS EDUARDO. Effects of aerobic and inspiratory training on skeletal muscle microRNA-1 and downstream-associated pathways in patients with heart failure. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, NOV 2019. Web of Science Citations: 0.
KLUSER SALES, ALLAN ROBSON; NEGRAO, MARCELO VAILATI; TESTA, LAURA; FERREIRA-SANTOS, LARISSA; RAMALHO GROEHS, RAPHAELA VILLAR; CARVALHO, BRUNA; TOSCHI-DIAS, EDGAR; ROCHA, NATALIA GALITO; MARTINS LAURINDO, FRANCISCO RAFAEL; DEBBAS, VICTOR; RONDON, MARIA URBANA P. B.; MANO, MAX SENA; HAJJAR, LUDHMILA ABRAHAO; GEHM HOFF, PAULO MARCELO; KALIL FILHO, ROBERTO; NEGRAO, CARLOS EDUARDO. Chemotherapy acutely impairs neurovascular and hemodynamic responses in women with breast cancer. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 317, n. 1, p. H1-H12, JUL 2019. Web of Science Citations: 2.
PEIXOTO DA FONSECA, GUILHERME WESLEY; DOS SANTOS, MARCELO RODRIGUES; DE SOUZA, FRANCIS RIBEIRO; DA COSTA, MARCEL JOSE A.; VON HAEHLING, STEPHAN; TAKAYAMA, LILIAM; PEREIRA, ROSA MARIA R.; NEGRAO, CARLOS EDUARDO; ANKER, STEFAN D.; DE NAZARE NUNES ALVES, MARIA JANIEIRE. Sympatho-Vagal Imbalance is Associated with Sarcopenia in Male Patients with Heart Failure. Arquivos Brasileiros de Cardiologia, v. 112, n. 6, p. 739-746, JUN 2019. Web of Science Citations: 2.
KE, WEINA; HONG, ENPING; SAITO, RENATA F.; RANGEL, MARIA CRISTINA; WANG, JIAN; VIARD, MATHIAS; RICHARDSON, MELINA; KHISAMUTDINOV, EMIL F.; PANIGAJ, MARTIN; DOKHOLYAN, V, NIKOLAY; CHAMMAS, ROGER; DOBROVOLSKAIA, MARINA A.; AFONIN, KIRILL A. RNA-DNA fibers and polygons with controlled immunorecognition activate RNAi, FRET and transcriptional regulation of NF-B in human cells. Nucleic Acids Research, v. 47, n. 3, p. 1350-1361, FEB 20 2019. Web of Science Citations: 10.
FERREIRA, JULIO C. B.; CAMPOS, JULIANE C.; QVIT, NIR; QI, XIN; BOZI, LUIZ H. M.; BECHARA, LUIZ R. G.; LIMA, VANESSA M.; QUELICONI, BRUNO B.; DISATNIK, MARIE-HELENE; DOURADO, PAULO M. M.; KOWALTOWSKI, ALICIA J.; MOCHLY-ROSEN, DARIA. A selective inhibitor of mitofusin 1-beta IIPKC association improves heart failure outcome in rats. NATURE COMMUNICATIONS, v. 10, JAN 18 2019. Web of Science Citations: 4.
SOUZA, RODRIGO W. A.; ALVES, CHRISTIANO R. R.; MEDEIROS, ALESSANDRA; ROLIM, NATALE; SILVA, GUSTAVO J. J.; MOREIRA, JOSE B. N.; ALVES, MARCIA N.; WOHLWEND, MARTIN; GEBRIEL, MOHAMMED; HAGEN, LARS; SHARMA, ANIMESH; KOCH, LAUREN G.; BRITTON, STEVEN L.; SLUPPHAUG, GEIR; WISLOFF, ULRIK; BRUM, PATRICIA C. Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. SCIENTIFIC REPORTS, v. 8, DEC 11 2018. Web of Science Citations: 1.
TAKANO, ANA P. C.; CAMPOS, JULIANE C.; VOLTARELLI, VANESSA A.; FERREIRA, JULIO C. B. Endoplasmic reticulum stress impairs cardiomyocyte contractility through JNK-dependent upregulation of BNIP3. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 272, p. 194-201, DEC 1 2018. Web of Science Citations: 2.
KIYUNA, LIGIA AKEMI; PRESTES E ALBUQUERQUE, RUDA; CHEN, CHE-HONG; MOCHLY-ROSEN, DARIA; BATISTA FERREIRA, JULIO CESAR. Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities. Free Radical Biology and Medicine, v. 129, p. 155-168, DEC 2018. Web of Science Citations: 14.
CAMPOS, JULIANE C.; BAEHR, LESLIE M.; GOMES, KATIA M. S.; BECHARA, LUIZ R. G.; VOLTARELLI, VANESSA A.; BOZI, LUIZ H. M.; RIBEIRO, MARCIO A. C.; FERREIRA, NIKOLAS D.; MOREIRA, JOSE B. N.; BRUM, PATRICIA C.; BODINE, SUE C.; FERREIRA, JULIO C. B. Exercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy. SCIENTIFIC REPORTS, v. 8, AUG 7 2018. Web of Science Citations: 4.
ALVES, CHRISTIANO R. R.; FARIA, DANIELE DE P.; CARNEIRO, CAMILA DE G.; GARCEZ, ALEXANDRE T.; GUTIERREZ, VANESSA P.; DAS NEVES, WILLIAN; DE ALMEIDA, NEY R.; CURY, YARA; CHAMMAS, ROGER; BRUM, PATRICIA C. F-18-Fluoride PET/CT and Tc-99m-MDP SPECT/CT can detect bone cancer at early stage in rodents. Life Sciences, v. 206, p. 29-34, AUG 1 2018. Web of Science Citations: 0.
DA SILVA JUNIOR, ILDEFONSO ALVES; DE SOUSA ANDRADE, LUCIANA NOGUEIRA; JANCAR, SONIA; CHAMMAS, ROGER. Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy. Clinics, v. 73, n. 1 2018. Web of Science Citations: 1.
GABRIEL-COSTA, D.; CUNHA, T. F.; PAIXAO, N. A.; FORTUNATO, R. S.; REGO-MONTEIRO, I. C. C.; BARRETO-CHAVES, M. L. M.; BRUM, P. C. Lactate-upregulation of lactate oxidation complex-related genes is blunted in left ventricle of myocardial infarcted rats. Brazilian Journal of Medical and Biological Research, v. 51, n. 11 2018. Web of Science Citations: 0.
ILDEFONSO ALVES DA SILVA JUNIOR; LUCIANA NOGUEIRA DE SOUSA ANDRADE; SONIA JANCAR; ROGER CHAMMAS. Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy. Clinics, v. 73, p. -, 2018.

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