Cancer and heart: new paradigms of diagnosis and treatment

• Grant number: 15/22814-5
• Support Opportunities: Research Projects - Thematic Grants
• Duration: November 01, 2016 - October 31, 2022
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Carlos Eduardo Negrão
• Grantee: Carlos Eduardo Negrão
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Pesquisadores principais:( Últimos ): Anamaria Aranha Camargo ; Ludhmila Abrahão Hajjar ; Maria Janieire de Nazaré Nunes Alves ; Maria Urbana Pinto Brandão Rondon ; Patricia Chakur Brum ; Paulo Marcelo Gehm Hoff ; Roberto Kalil Filho ; Roger Chammas
• Pesquisadores principais:( Antigos ): Edilamar Menezes de Oliveira
• Associated researchers: Christina May Moran de Brito ; Fátima Solange Pasini ; Gilberto de Castro Junior ; Julio Cesar Batista Ferreira ; Luciana Nogueira de Sousa Andrade ; Luiz Fernando Lima Reis ; Maria Cristina Rodrigues Rangel ; Marília Harumi Higuchi dos Santos ; Marisa Passarelli ; Paula Fontes Asprino ; Paulo Rizzo Ramires ; Renata de Freitas Saito ; Silvia Moreira Ayub Ferreira ; Tatiane Katsue Furuya
• Associated grant(s): 20/00842-5 - Preventing respiratory muscle dysfunction to improve survival in chronic disease by targeting a novel drug-exercise therapeutic axis, AP.R SPRINT; 18/22579-4 - Exosomal microRNAs as circulating biomarkers and mediators of the cardioprotective effect in patients undergoing cancer therapies, AP.R SPRINT; 17/18081-8 - AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications, AR.EXT; + associated grants 17/08548-6 - Autophagy: from molecular principles to human diseases, AR.EXT; 17/50029-6 - The use if RNA-based nano formulations to improve the efficacy of breast cancer treatment and reduce therapy-induced cardiotoxicity, AP.R SPRINT; 16/50336-3 - Predicting survival in non-small-cell lung cancer: a link between cancer cachexia, cardiorespiratory fitness and cancer immune surveillance?, AP.R SPRINT - associated grants
• Associated scholarship(s): 18/14491-0 - Role of aldehydes metabolism in the doxorubicin-induced cardiomyopathy: preventive and therapeutic effects of Alda-1, BP.PD; 17/22069-3 - The role of MicroRNA-33a and sirtuine protein 6 in the metabolism and progression of Colon Cancer in mummy submitted to aerobic physical training, BP.DR; 16/26169-0 - Potential therapeutic targets induced by aerobic exercise training for the treatment of cancer cachexia: a study of ribosomal proteins, BP.PD; + associated scholarships 17/13133-0 - Relative role of physical activity on mitochondrial density and bioenergetics of infiltrating T lymphocytes from tumor microenvironment, BP.PD; 16/22835-5 - Effects of voluntary physical activity on cardiac function and structure in animal models of cancer cachexia, BP.MS; 15/09919-2 - Circulating miRNAs as biomarkers of cardiotoxicity and therapeutic potential in breast cancer, BP.PD; 15/05427-8 - Impact of adjuvant chemotherapy in autonomic cardiovascular regulation in patients with colon cancer, BP.PD; 14/11671-6 - Effect of high intensity interval training versus continuous moderate in the peripheral reflex mechanisms of control of the sympathetic activity in patients with heart failure, BP.PD; 13/15651-7 - Effects of Aerobic Exercise Training Associated with Inspiratory Muscle Training on Skeletal Myopathy in Patients with Heart Failure, BP.PD; 13/07651-7 - Prognostic value of the oscillatory pattern of muscle sympathetic nerve activity in patients with heart failure, BP.PD - associated scholarships

Abstract

Despite of the uninterrupted development of new medications for the treatment of cancer, the survival rate continues low especially in those patients in the advanced stage of the disease. Recent observations show that new therapeutics increase the susceptibility for cardiovascular diseases, which turns out to be the treatment of cancer even more complex. Cardiac dysfunction due to cardiotoxicity has been found in 10-15% breast cancer patients submitted to chemotherapy. Cardiac alterations associated with autonomicdysfunction have been recently documented in patients submitted to radiotherapy for treatment of lymphoma. Body weight gain, insulin resistance and hyperglycemia, dyslipidemia, and high blood pressure are very frequent in patients submitted to androgenic blockade or orquiectomy for the treatment of prostate adenocarcinoma. Therefore, the search for new treatments for cancer and elimination of collateral events caused by medications are great challenge in nowadays.Physical inactivity is very common in oncological patients. The debilitation due to the disease, treatment and demotivation contribute to the low level of physical activity in patients with cancer. On the other hand, studies involving large number of individual are unanimous in demonstrating the significant association between physical fitness and survival rate regardless of diseases. This knowledge suggests that exercise training may be an adjuvant strategy in the treatment of cancer. In fact, recent studies demonstrate that exercise training improves physical capacity and quality of life in patients suffering of cancer.The aim of our investigation is to search the molecular and autonomic mechanisms involved in the cardiovascular alterations provoked by cancer or chemotherapy and radiotherapy used in the treatment of this disease. Not less important will be the studies focused on the new therapeutic paradigms based on cellular and molecular principles, medications and exercise training for the treatment of cardiovascular diseases associated with cancer with special attention in the cardiac and skeletal toxicity.To accomplish these goals, 21 studies will be conducted in three areas: Cardio/Oncology, Oncologye Cardiology. (AU)

Scientific publications

(61)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

T.F. CUNHA; J.S. VIEIRA; J.B. SANTOS; M.A. COELHO; P.C. BRUM; D. GABRIEL-COSTA. Lactate modulates cardiac gene expression in mice during acute physical exercise. Brazilian Journal of Medical and Biological Research, v. 55, 2022-04-27. (14/25957-9, 15/22814-5)

KIYUNA, LIGIA AKEMI; PRESTES E ALBUQUERQUE, RUDA; CHEN, CHE-HONG; MOCHLY-ROSEN, DARIA; BATISTA FERREIRA, JULIO CESAR. Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities. Free Radical Biology and Medicine, v. 129, p. 155-168, DEC 2018. (17/16694-2, 17/14426-0, 16/00900-0, 15/22814-5, 15/20783-5, 12/05765-2, 13/07937-8)

ANTUNES-CORREA, LIGIA M.; TREVIZAN, PATRICIA F.; BACURAU, ALINE V. N.; FERREIRA-SANTOS, LARISSA; GOMES, JOAO L. P.; URIAS, URSULA; OLIVEIRA, PATRICIA A.; ALVES, MARIA JANIEIRE N. N.; DE ALMEIDA, DIRCEU R.; BRUM, PATRICIA C.; et al. Effects of aerobic and inspiratory training on skeletal muscle microRNA-1 and downstream-associated pathways in patients with heart failure. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, NOV 2019. (15/22814-5, 13/15651-7)

PEIXOTO DA FONSECA, GUILHERME WESLEY; DOS SANTOS, MARCELO RODRIGUES; DE SOUZA, FRANCIS RIBEIRO; DA COSTA, MARCEL JOSE A.; VON HAEHLING, STEPHAN; TAKAYAMA, LILIAM; PEREIRA, ROSA MARIA R.; NEGRAO, CARLOS EDUARDO; ANKER, STEFAN D.; DE NAZARE NUNES ALVES, MARIA JANIEIRE. Desequilíbrio Simpático-Vagal está Associado com Sarcopenia em Pacientes do Sexo Masculino com Insuficiência Cardíaca. Arquivos Brasileiros de Cardiologia, v. 112, n. 6, p. 739-746, JUN 2019. (16/24306-0, 15/22814-5)

KLUSER SALES, ALLAN ROBSON; NEGRAO, MARCELO VAILATI; TESTA, LAURA; FERREIRA-SANTOS, LARISSA; RAMALHO GROEHS, RAPHAELA VILLAR; CARVALHO, BRUNA; TOSCHI-DIAS, EDGAR; ROCHA, NATALIA GALITO; MARTINS LAURINDO, FRANCISCO RAFAEL; DEBBAS, VICTOR; et al. Chemotherapy acutely impairs neurovascular and hemodynamic responses in women with breast cancer. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 317, n. 1, p. H1-H12, JUL 2019. (14/11671-6, 15/22814-5)

DE AVILA PELOZIN, BRUNO ROCHA; RENO SOCI, URSULA PAULO; PENTEADO GOMES, JOAO LUCAS; DE OLIVEIRA, EDILAMAR MENEZES; FERNANDES, TIAGO. MTOR Signaling-Related MicroRNAs As Cardiac Hypertrophy Modulators In High- Volume Endurance Training. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 53, n. 8, p. 1-pg., 2021-08-01. (15/22814-5, 15/17275-8)

MORELLI, ANA PAULA; TORTELLI, THARCISIO CITRANGULO JR JR; BETIM PAVAN, ISADORA CAROLINA; SILVA, FERNANDO RIBACK; GRANATO, DANIELA CAMPOS; PERUCA, GUILHERME FRANCISCO; PAULETTI, BIANCA ALVES; DOMINGUES, ROMENIA RAMOS; NEVES BEZERRA, ROSANGELA MARIA; DE MOURA, LEANDRO PEREIRA; et al. Metformin impairs cisplatin resistance effects in A549 lung cancer cells through mTOR signaling and other metabolic pathways. International Journal of Oncology, v. 58, n. 6, JUN 2021. (16/02483-7, 19/00607-9, 15/22814-5, 17/04269-5, 15/16601-9, 18/14818-9, 16/06457-0, 12/13558-7)

GOMES-SANTOS, IGOR L.; JORDAO, CAMILA P.; PASSOS, CLEVIA S.; BRUM, PATRICIA C.; OLIVEIRA, EDILAMAR M.; CHAMMAS, ROGER; CAMARGO, ANAMARIA A.; NEGRAO, CARLOS E.. Exercise Training Preserves Myocardial Strain and Improves Exercise Tolerance in Doxorubicin-Induced Cardiotoxicity. FRONTIERS IN CARDIOVASCULAR MEDICINE, v. 8, APR 1 2021. (16/21320-1, 15/19076-2, 15/22814-5, 14/13690-8)

TOSCHI-DIAS, EDGAR; MONTANO, NICOLA; TOBALDINI, ELEONORA; TREVIZAN, PATRICIA F.; GROEHS, V, RAPHAELA; ANTUNES-CORREA, LIGIA M.; NOBRE, THAIS S.; LOBO, DENISE M.; SALES, ALLAN R. K.; UENO-PARDI, LINDA M.; et al. Oscillatory Pattern of Sympathetic Nerve Bursts Is Associated With Baroreflex Function in Heart Failure Patients With Reduced Ejection Fraction. FRONTIERS IN NEUROSCIENCE, v. 15, AUG 31 2021. (10/50048-1, 15/17642-0, 13/07651-7, 15/22814-5)

DOS SANTOS, MARCELO RODRIGUES; PEIXOTO DA FONSECA, GUILHERME WESLEY; SHERVENINAS, LETICIA PIRONATO; DE SOUZA, FRANCIS RIBEIRO; BATTAGLIA FILHO, ANTONIO CARLOS; NOVAES, CAIO EDUARDO; RODRIGUES PEREIRA, ROSA MARIA; NEGRAO, CARLOS EDUARDO; PEREIRA BARRETTO, ANTONIO CARLOS; DE NAZARE NUNES ALVES, MARIA-JANIEIRE. Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure. ESC HEART FAILURE, v. 7, n. 3, MAR 2020. (15/22814-5, 16/24833-0, 16/24306-0)

SALES, ALLAN R. K.; AZEVEDO, LUCIENE F.; SILVA, THIAGO O. C.; RODRIGUES, AMANDA G.; OLIVEIRA, PATRICIA A.; JORDAO, CAMILA P.; ANDRADE, ANA C. M.; URIAS, URSULA; GUIMARAES, GUILHERME V.; BOCCHI, EDIMAR A.; et al. High-Intensity Interval Training Decreases Muscle Sympathetic Nerve Activity and Improves Peripheral Vascular Function in Patients With Heart Failure With Reduced Ejection Fraction. Circulation-Heart Failure, v. 13, n. 8, AUG 2020. (15/22814-5, 17/25613-6, 10/08990-1, 14/11671-6)

ALVES, CHRISTIANO R. R.; NEVES, WILLIAN DAS; ALMEIDA, NEY R. DE; EICHELBERGER, ERIC J.; JANNIG, PAULO R.; VOLTARELLI, VANESSA A.; TOBIAS, GABRIEL C.; BECHARA, LUIZ R. G.; FARIA, DANIELE DE PAULA; ALVES, MARIA J. N.; et al. Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/ TRIP15/ALIEN. MOLECULAR METABOLISM, v. 39, SEP 2020. (16/50336-3, 12/02528-0, 14/03016-8, 12/25240-1, 15/22814-5, 16/01478-0, 16/20187-6)

KE, WEINA; HONG, ENPING; SAITO, RENATA F.; RANGEL, MARIA CRISTINA; WANG, JIAN; VIARD, MATHIAS; RICHARDSON, MELINA; KHISAMUTDINOV, EMIL F.; PANIGAJ, MARTIN; DOKHOLYAN, V, NIKOLAY; et al. RNA-DNA fibers and polygons with controlled immunorecognition activate RNAi, FRET and transcriptional regulation of NF-B in human cells. Nucleic Acids Research, v. 47, n. 3, p. 1350-1361, FEB 20 2019. (17/50029-6, 15/22814-5)

PATINO, ANGELICA M.; JUNQUEIRA, MARA S.; ZHANG, XIAOMENG; BAILEY, KATE; IBRAHIM-HASHIM, ARIG; GILLIES, ROBERT J.; CHAMMAS, ROGER. Transient increase of tumor perfusion using hypertonic saline. MOLECULAR CANCER THERAPEUTICS, v. 17, n. 1, p. 2-pg., 2018-01-01. (13/06120-8, 15/22814-5)

SILVEIRA, ANDRE; GOMES, JOAO; ROQUE, FERNANDA; FERNANDES, TIAGO; DE OLIVEIRA, EDILAMAR MENEZES. MicroRNAs in Obesity-Associated Disorders: The Role of Exercise Training. Obesity Facts, v. 15, n. 2, p. 13-pg., 2022-01-20. (15/22814-5, 17/22069-3, 15/17275-8)

BUSTOS, SILVINA ODETE; ANTUNES, FERNANDA; RANGEL, MARIA CRISTINA; CHAMMAS, ROGER. Emerging Autophagy Functions Shape the Tumor Microenvironment and Play a Role in Cancer Progression-Implications for Cancer Therapy. FRONTIERS IN ONCOLOGY, v. 10, NOV 25 2020. (15/22814-5, 14/03742-0)

ALVES, CHRISTIANO R. R.; EICHELBERGER, ERIC J.; DAS NEVES, WILLIAN; RIBEIRO, MARCIO A. C.; BECHARA, LUIZ R. G.; VOLTARELLI, VANESSA A.; DE ALMEIDA, NEY R.; HAGEN, LARS; SHARMA, ANIMESH; FERREIRA, JULIO C. B.; et al. Cancer-induced muscle atrophy is determined by intrinsic muscle oxidative capacity. FASEB JOURNAL, v. 35, n. 7, JUL 2021. (16/50336-3, 16/01478-0, 12/25240-1, 16/20187-6, 15/22814-5, 14/03016-8, 12/02528-0)

TREVIZAN, PATRICIA F.; ANTUNES-CORREA, LIGIA M.; LOBO, DENISE M. L.; OLIVEIRA, PATRICIA A.; DE ALMEIDA, DIRCEU R.; ABDUCH, MARIA CRISTINA D.; MATHIAS JUNIOR, WILSON; HAJJAR, LUDHMILA ABRAHAO; KALIL FILHO, ROBERTO; NEGRAO, CARLOS EDUARDO. Effects of inspiratory muscle training combined with aerobic exercise training on neurovascular control in chronic heart failure patients. ESC HEART FAILURE, JUN 2021. (13/15651-7, 15/22814-5)

PELOZIN, BRUNO R. A.; SOCI, URSULA P. R.; GOMES, JOAO L. P.; OLIVEIRA, EDILAMAR M.; FERNANDES, TIAGO. TOR signaling-related microRNAs as cardiac hypertrophy modulators in high-volume endurance trainin. Journal of Applied Physiology, v. 132, n. 1, p. 126-139, JAN 2022. (15/22814-5, 15/17275-8)

GABRIEL-COSTA, D.; CUNHA, T. F.; PAIXAO, N. A.; FORTUNATO, R. S.; REGO-MONTEIRO, I. C. C.; BARRETO-CHAVES, M. L. M.; BRUM, P. C.. Lactate-upregulation of lactate oxidation complex-related genes is blunted in left ventricle of myocardial infarcted rats. Brazilian Journal of Medical and Biological Research, v. 51, n. 11, 2018. (15/22814-5)

TORTELLI, JR., THARCISIO CITRANGULO; TAMURA, RODRIGO ESAKI; JUNQUEIRA, MARA DE SOUZA; MORORO, JANIO DA SILVA; BUSTOS, SILVINA ODETE; NATALINO, RENATO JOSE MENDONCA; RUSSELL, SHONAGH; DESAUBRY, LAURENT; STRAUSS, BRYAN ERIC; CHAMMAS, ROGER. Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells. AGING-US, v. 13, n. 18, p. 21914-21940, SEP 30 2021. (15/26580-9, 19/08147-7, 15/22814-5)

VIEIRA, J. S.; CUNHA, T. F.; PAIXAO, N. A.; DOURADO, P. M.; CARRASCOZA, L. S.; BACURAU, A. V. N.; BRUM, P. C.. Exercise intolerance establishment in pulmonary hypertension: Preventive effect of aerobic exercise training. Life Sciences, v. 261, NOV 15 2020. (15/22814-5, 16/24284-6, 14/25957-9)

CUNHA, T. F.; VIEIRA, J. S.; SANTOS, J. B.; COELHO, M. A.; BRUM, P. C.; GABRIEL-COSTA, D.. Lactate modulates cardiac gene expression in mice during acute physical exercise. Brazilian Journal of Medical and Biological Research, v. 55, n. 1, p. 9-pg., 2022-01-01. (15/22814-5, 11/00728-9, 14/25957-9)

PEREIRA, MARCELO G.; VOLTARELLI, VANESSA A.; TOBIAS, GABRIEL C.; DE SOUZA, LARA; BORGES, GABRIELA S.; PAIXAO, AILMA O.; DE ALMEIDA, NEY R.; BOWEN, THOMAS SCOTT; DEMASI, MARILENE; MIYABARA, ELEN H.; et al. erobic Exercise Training and In Vivo Akt Activation Counteract Cancer Cachexia by Inducing a Hypertrophic Profile through eIF-2 alpha Modulatio. CANCERS, v. 14, n. 1, JAN 2022. (16/26169-0, 17/13133-0, 20/12279-3, 15/22814-5, 18/02351-9)

MORELLI, ANA PAULA; TORTELLI JR, THARCISIO CITRANGULO; SILVA MANCINI, MARIANA CAMARGO; BETIM PAVAN, ISADORA CAROLINA; SALVINO SILVA, LUIZ GUILHERME; SEVERINO, MATHEUS BRANDEMARTE; GRANATO, DANIELA CAMPOS; PESTANA, NATHALIE FORTES; SABOIA PONTE, LUIS GUSTAVO; PERUCA, GUILHERME FRANCISCO; et al. TAT3 contributes to cisplatin resistance, modulating EMT markers, and the mTOR signaling in lung adenocarcinom. Neoplasia, v. 23, n. 10, p. 1048-1058, OCT 2021. (19/25582-9, 15/22814-5, 15/00311-1, 18/14818-9, 19/00607-9, 20/09527-5)

IMPROTA-CARIA, ALEX C.; SOCI, URSULA P. R.; RODRIGUES, LUIS F.; FERNANDES, TIAGO; OLIVEIRA, EDILAMAR M.. MicroRNAs regulating pathophysiological processes in obesity: the impact of exercise training. CURRENT OPINION IN PHYSIOLOGY, v. 33, p. 7-pg., 2023-06-01. (18/22579-4, 22/00531-5, 15/22814-5, 21/06229-6, 22/02339-4)

CUNHA, MATEUS TRINCONI; DE SOUZA BORGES, ANA PAULA; JARDIM, VINICIUS CARVALHO; FUJITA, ANDRE; DE CASTRO JR, GILBERTO. Predicting survival in metastatic non-small cell lung cancer patients with poor ECOG-PS: A single-arm prospective study. CANCER MEDICINE, v. N/A, p. 11-pg., 2022-09-26. (15/22814-5, 16/20187-6, 18/21934-5, 19/03615-2)

DE CASTRO, G., JR.; DAS NEVES SILVA, W.; BORGES, A. P. D. S.; JARDIM, V. C.; BRUM, P. C. B. C.; FUJITA, A.. Impact of systemic inflammation, intramuscular adipose tissue content, and EORTC-QLQ-CAX24 symptom scale on the prognosis of patients with advanced non-small-cell lung cancer. Annals of Oncology, v. 31, p. 1-pg., 2020-09-01. (15/22814-5, 16/20187-6)

FERNANDES, L. G.; TOBIAS, G. C.; PAIXAO, A. O.; DOURADO, P. M.; VOLTARELLI, V. A.; BRUM, P. C.. Exercise training delays cardiac remodeling in a mouse model of cancer cachexia. Life Sciences, v. 260, NOV 1 2020. (14/25830-9, 15/22814-5, 16/22835-5)

FERREIRA, JULIO CESAR BATISTA. Mitochondrial Dysfunction in Degenerative Diseases. CELLS, v. 11, n. 9, p. 3-pg., 2022-05-01. (13/07937-8, 19/25049-9, 15/22814-5, 18/18627-3)

DAS NEVES, WILLIAN; ALVES, CHRISTIANO R. R.; DE SOUZA BORGES, ANA PAULA; DE CASTRO JR, GILBERTO. Serum Creatinine as a Potential Biomarker of Skeletal Muscle Atrophy in Non-small Cell Lung Cancer Patients. FRONTIERS IN PHYSIOLOGY, v. 12, APR 12 2021. (15/22814-5, 14/03016-8, 12/25240-1, 12/02528-0, 16/01478-0)

GROEHS, RAPHAELA V.; NEGRAO, MARCELO V.; HAJJAR, LUDHMILA A.; JORDAO, CAMILA P.; CARVALHO, BRUNA P.; TOSCHI-DIAS, EDGAR; ANDRADE, ANA C.; HODAS, FABIANA P.; ALVES, MARIA J. N. N.; SARMENTO, ADRIANA O.; et al. Adjuvant Treatment with5-Fluorouraciland Oxaliplatin Does Not Influence Cardiac Function, Neurovascular Control, and Physical Capacity in Patients with Colon Cancer. ONCOLOGIST, v. 25, n. 12, AUG 2020. (13/07651-7, 15/22814-5, 15/05427-8, 15/17642-0)

PEIXOTO DA FONSECA, GUILHERME WESLEY; MACEDO, TANIA GARFIAS; EBNER, NICOLE; DOS SANTOS, MARCELO RODRIGUES; DE SOUZA, FRANCIS RIBEIRO; MADY, CHARLES; TAKAYAMA, LILIAM; RODRIGUES PEREIRA, ROSA MARIA; DOEHNER, WOLFRAM; ANKER, STEFAN D.; et al. Ms, muscle strength, and functional capacity in patients with heart failure of Chagas disease and other aetiologies. ESC HEART FAILURE, AUG 2020. (15/22814-5, 16/24306-0)

GARCIA, ADRIANA A.; KOPERNIKU, ANA; FERREIRA, JULIO C. B.; MOCHLY-ROSEN, DARIA. Treatment strategies for glucose-6-phosphate dehydrogenase deficiency: past and future perspectives. TRENDS IN PHARMACOLOGICAL SCIENCES, v. 42, n. 10, p. 829-844, OCT 2021. (15/22814-5, 13/07937-8, 18/18627-3, 19/25049-9)

TREVIZAN, PATRICIA F.; ANTUNES-CORREA, LIGIA M.; LOBO, DENISE M. L.; OLIVEIRA, PATRICIA A.; DE ALMEIDA, DIRCEU R.; ABDUCH, MARIA CRISTINA D.; MATHIAS JUNIOR, WILSON; HAJJAR, LUDHMILA ABRAHAO; KALIL FILHO, ROBERTO; NEGRAO, CARLOS EDUARDO. Effects of inspiratory muscle training combined with aerobic exercise training on neurovascular control in chronic heart failure patients. ESC HEART FAILURE, v. 8, n. 5, p. 3845-3854, OCT 2021. (15/22814-5, 13/15651-7)

SILVA, THIAGO O. C.; SALES, ALLAN R. K.; ARAUJO, GUSTAVO S. M.; FONSECA, GUILHERME W. P.; BRAGA, PEDRO G. S.; FARIA, DIEGO; ROCHA, HELENA N. M.; ROCHA, NATALIA G.; LIMA, MARTA F.; MADY, CHARLES; et al. Disturbed Blood Flow Acutely Increases Endothelial Microparticles and Decreases Flow Mediated Dilation in Patients With Heart Failure With Reduced Ejection Fraction. FRONTIERS IN PHYSIOLOGY, v. 12, MAR 11 2021. (15/22814-5, 14/11671-6, 17/25613-6)

DA COSTA, TASSIA S. R.; URIAS, URSULA; NEGRAO, V, MARCELO; JORDAO, CAMILA P.; PASSOS, CLEVIA S.; GOMES-SANTOS, IGOR L.; SALEMI, VERA MARIA C.; CAMARGO, ANAMARIA A.; BRUM, PATRICIA C.; OLIVEIRA, EDILAMAR M.; et al. Breast Cancer Promotes Cardiac Dysfunction Through Deregulation of Cardiomyocyte Ca2+-Handling Protein Expression That is Not Reversed by Exercise Training. JOURNAL OF THE AMERICAN HEART ASSOCIATION, v. 10, n. 5, MAR 2 2021. (15/22814-5, 15/19076-2, 14/13690-8)

FONSECA, G. W. P. D.; DOS SANTOS, MARCELO RODRIGUES; DE SOUZA, FRANCIS RIBEIRO; TAKAYAMA, LILIAM; RODRIGUES PEREIRA, ROSA MARIA; NEGRAO, CARLOS EDUARDO; NUNES ALVES, MARIA-JANIEIRE DE NAZARE. Discriminating sarcopenia in overweight/obese male patients with heart failure: the influence of body mass index. ESC HEART FAILURE, v. 7, n. 1, DEC 2019. (15/22814-5, 16/24306-0)

CAMPOS, JULIANE C.; CHEN, CHE-HONG; FERREIRA, JULIO C. B.. Comment on: ``Aldehyde dehydrogenases contribute to skeletal muscle homeostasis in healthy, aging, and Duchenne muscular dystrophy patients{''} by Etienne et al.. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, JUL 2020. (15/22814-5, 17/16540-5, 19/25049-9, 19/18444-9)

DA SILVA JUNIOR, ILDEFONSO ALVES; DE SOUSA ANDRADE, LUCIANA NOGUEIRA; JANCAR, SONIA; CHAMMAS, ROGER. Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy. Clinics, v. 73, n. 1, 2018. (15/22814-5, 13/15719-0)

ALVES, CHRISTIANO R. R.; FARIA, DANIELE DE P.; CARNEIRO, CAMILA DE G.; GARCEZ, ALEXANDRE T.; GUTIERREZ, VANESSA P.; DAS NEVES, WILLIAN; DE ALMEIDA, NEY R.; CURY, YARA; CHAMMAS, ROGER; BRUM, PATRICIA C.. F-18-Fluoride PET/CT and Tc-99m-MDP SPECT/CT can detect bone cancer at early stage in rodents. Life Sciences, v. 206, p. 29-34, AUG 1 2018. (15/22814-5, 14/03016-8, 16/01478-0, 12/02528-0, 12/25240-1)

CHAMMAS, ROGER; DE SOUSA ANDRADE, LUCIANA NOGUEIRA; JANCAR, SONIA. Oncogenic effects of PAFR ligands produced in tumours upon chemotherapy and radiotherapy. NATURE REVIEWS CANCER, v. 17, n. 4, APR 2017. (13/15719-0, 15/22814-5)

AZEVEDO VOLTARELLI, VANESSA; CORONADO, MICHAEL; GONCALVES FERNANDES, LARISSA; CRUZ CAMPOS, JULIANE; JANNIG, PAULO ROBERTO; BATISTA FERREIRA, JULIO CESAR; FAJARDO, GIOVANNI; CHAKUR BRUM, PATRICIA; BERNSTEIN, DANIEL. beta(2)-Adrenergic Signaling Modulates Mitochondrial Function and Morphology in Skeletal Muscle in Response to Aerobic Exercise. CELLS, v. 10, n. 1, JAN 2021. (15/22814-5)

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