Development of calcium phosphate nanoparticles functionalized with acidic monomers for dental remineralization

• Grant number: 16/50321-6
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2017
• End date: December 31, 2018
• Field of knowledge: Health Sciences - Dentistry - Dental Materials
• Agreement: University of Sydney
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Roberto Ruggiero Braga
• Grantee: Roberto Ruggiero Braga
• Principal researcher abroad: Ramin Rohanizadeh
• Institution abroad: University of Sydney, Australia
• Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 15/15019-4 - Development of functionalized calcium phosphate nanoparticles for use in resin-based dental composites, AP.R

Abstract

Calcium phosphate (CaP) nanoparticles functionalization with ethylene glycol dimethacrylete derivatives does not reduce agglomeration. Therfore, alternative strategies are necessary in order to stabilize the nanoparticles and prevent agglomeration, while creating reactive sites to improve the interaction with the composite resin matrix. Citric acid has been used as nanoparticle stabilizer due to its three carboxylic groups, which increase the surface charge of the particles. Methacrylate monomers containing phosphoric acid groups also present one or two negatively charged sites, potentially capable of reducing nanoparticle agglomeration. This project has the purpose of investigating the effect of different organic functionalizing agents on CaP nanoparticles formation and test these particles as ion-releasing fillers in experimental resin-based composites. Experimental composites will be evaluated for mechanical properties, ion release and their efficacy in reducing mineral loss of enamel exposed to acidic challenge. The hypothesis is that negatively charged organic molecules (such as citric acid, acrylic acid and methacryloyloxyethyl phosphate) will contribute to reduce nanoparticle agglomeration, while those also presenting polymerizable vinyl groups (acrylic acid and MOEP) will present a stronger interaction with the composite resin matrix. DEGDMA will also be tested, as it has shown the most promising results on the undergoing project testing different EGDMA derivatives. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CHIARI, MARINA D. S.; RODRIGUES, MARCELA C.; PINTO, MIRELLA F. C.; VIEIRA, DOUGLAS N.; VICHI, FLAVIO M.; VEGA, OSCAR; CHRZANOWSKI, WOJCIECH; NAGAOKA, NORIYUKI; BRAGA, ROBERTO R.. Development of brushite particles synthesized in the presence of acidic monomers for dental applications. Materials Science & Engineering C-Materials for Biological Applications, v. 116, NOV 2020. (17/06446-1, 16/50321-6, 16/25971-7)