Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity

• Grant number: 15/23376-1
• Support Opportunities: Research Projects - Thematic Grants
• Start date: February 01, 2017
• End date: November 30, 2022
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Thiago dos Santos Moreira
• Grantee: Thiago dos Santos Moreira
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Ana Carolina Takakura Moreira
• Associated researchers: Norberto Garcia Cairasco
• Associated research grant(s): 17/12072-7 - Multi-user equipment approved in grant 2015/23376-1: Zeiss AxioImager microscope with fluorescence, light/dark field, digital camera and hardware and system analysis, AP.EMU
• Associated scholarship(s): 21/09377-6 - Contribution of the sensorial olfactory neurons in the hypercapnia and hypoxia ventilatory response in conscious mice, BP.DD; 21/02006-2 - Involvement of microglial cells in the retrotrapezoid nucleus in response to the activation of the chemoreflex, BP.IC; 19/20504-0 - Respiratory changes elicit by neurokinin receptors at the level of the retrotrapezoid nucleus, BP.DR; + associated scholarships 20/08620-1 - Hypothalamus and retrotrapezoid nucleus interaction in the control of breathing activity, BP.DR; 19/20990-1 - Contribution of the sensorial olfactory neurons in the hypercapnia ventilatory response in conscious mice, BP.MS; 19/09718-8 - Role of microglial cell activation in response to increased levels of CO2 in the control of respiratory activity, BP.IC; 19/09323-3 - Regulation of blood flow in the ventrolateral surface of the medulla in animal a model of Parkinson's disease, BP.PD; 18/13707-9 - Involvement of the chemosensitive neurons in the retrotrapezoid nucleus for the control of postinspiratory activity, BP.DR; 18/13704-0 - Study of the influence of omega-3 in the respiratory changes observed in a model of Parkinson's Disease induced by bilateral injection of 6-hydroxy-dopamine in CPU, BP.IC; 17/08696-5 - Purinergic signalling within the Retrotrapezoid Nucleus region: role of breathing control in the temporal lobe epilepsy model, BP.PD; 17/10242-2 - Role of OLIG3 transcription factor on ventilatory responses to hypoxia and hypercapnia, BP.IC; 17/01380-2 - Pedunculo pontine tegmental nucleus and brainstem respiratory interactions in breathing, BP.DD - associated scholarships

Abstract

Breathing automaticity and chemoreception are inseparable neural processes. The retrotrapezoid nucleus (RTN), a group of glutamatergic neurons that express the transcription factor Phox2b, may be a crucial nodal point through which breathing automaticity is regulated to maintain CO2 constant. Additional evidence that RTN neurons have central respiratory chemoreceptor properties is presented, but this is only one of many factors that determine their activity. The RTN is also regulated by powerful inputs from the carotid bodies and, at least in the adult, by many other synaptic inputs. It is also established that RTN neurons may control the activity of the downstream central respiratory pattern generator. Specifically, RTN neurons (a) innervate the entire ventral respiratory column and (b) control both inspiration and expiration. Based on the information above, this project will intend to analyze the role of RTN chemoreceptors neurons in the control of breathing under physiological, pathological and during development in mammals. (AU)

Scientific publications

(53)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERNANDES-JUNIOR, SILVIO A.; CARVALHO, KARIN S.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Correlation between neuroanatomical and functional respiratory changes observed in an experimental model of Parkinson's disease. Experimental Physiology, v. 103, n. 10, p. 1377-1389, OCT 1 2018. (15/23376-1, 16/23281-3)

MALHEIROS-LIMA, MILENE R.; TOTOLA, LEONARDO T.; LANA, MARLOUS V. G.; STRAUSS, BRYAN E.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. Breathing responses produced by optogenetic stimulation of adrenergic C1 neurons are dependent on the connection with preBotzinger complex in rats. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 470, n. 11, p. 1659-1672, NOV 2018. (14/07698-6, 15/23376-1, 16/23281-3, 16/22069-0)

TOTOLA, LEONARDO T.; MALHEIROS-LIMA, MILENE R.; DELFINO-PEREIRA, POLIANNA; DEL VECCHIO, FLAVIO; SOUZA, FELIPE C.; TAKAKURA, ANA C.; GARCIA-CAIRASCO, NORBERTO; MOREIRA, THIAGO S.. Amygdala rapid kindling impairs breathing in response to chemoreflex activation. Brain Research, v. 1718, p. 159-168, SEP 1 2019. (16/23281-3, 05/56447-7, 15/23376-1)

BATISTA, LUARA A.; CABRAL, LAIS M.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. nhibition of anandamide hydrolysis does not rescue respiratory abnormalities observed in an animal model of Parkinson's diseas. Experimental Physiology, v. 107, n. 2, DEC 2021. (19/01236-4, 17/18074-1, 15/23376-1)

MALHEIROS-LIMA, MILENE R.; SILVA, JOSIANE N.; SOUZA, FELIPE C.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. C1 neurons are part of the circuitry that recruits active expiration in response to the activation of peripheral chemoreceptors. eLIFE, v. 9, JAN 23 2020. (16/23281-3, 15/23376-1)

MALHEIROS-LIMA, MILENE R.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. DEPLETION OF ROSTRAL VENTROLATERAL MEDULLARY CATECHOLAMINERGIC NEURONS IMPAIRS THE HYPDXIC VENTILATORY RESPONSE IN CONSCIOUS RATS. Neuroscience, v. 351, p. 1-14, MAY 20 2017. (14/07698-6, 14/22406-1, 15/23376-1)

HAWKINS, VIRGINIA E.; TAKAKURA, ANA C.; TRINH, ASHLEY; MALHEIROS-LIMA, MILENE R.; CLEARY, COLIN M.; WENKER, IAN C.; DUBREUIL, TODD; RODRIGUEZ, ELLIOT M.; NELSON, MARK T.; MOREIRA, THIAGO S.; et al. Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe. eLIFE, v. 6, APR 7 2017. (14/07698-6, 14/22406-1, 15/23376-1, 16/22069-0)

OLIVEIRA, LUIZ M.; TUPPY, MARINA; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Role of the locus coeruleus catecholaminergic neurons in the chemosensory control of breathing in a Parkinson's disease model. Experimental Neurology, v. 293, p. 172-180, JUL 2017. (15/18842-3, 16/23281-3, 14/22406-1, 15/23376-1)

SOBRINHO, CLEYTON R.; GONCALVES, CHRISTOPHER M.; TAKAKURA, ANA C.; MULKEY, DANIEL K.; MOREIRA, THIAGO S.. Fluorocitrate-mediated depolarization of astrocytes in the retrotrapezoid nucleus stimulates breathing. Journal of Neurophysiology, v. 118, n. 3, p. 1690-1697, SEP 2017. (14/22406-1, 11/13462-7, 15/23376-1, 15/12827-2, 16/22069-0)

MOREIRA, THIAGO S.; ANTUNES, VAGNER R.; FALQUETTO, BARBARA; MARINA, NEPHTALI. Long-term stimulation of cardiac vagal preganglionic neurons reduces blood pressure in the spontaneously hypertensive rat. Journal of Hypertension, v. 36, n. 12, p. 2444-2452, DEC 2018. (15/23376-1, 16/21991-3, 16/22069-0)

OLIVEIRA, LUIZ M.; OLIVEIRA, MARIA A.; MORIYA, HENRIQUE T.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Respiratory disturbances in a mouse model of Parkinson's disease. Experimental Physiology, v. 104, n. 5, p. 729-739, MAY 1 2019. (15/23376-1, 16/23281-3, 15/18842-3, 17/12266-6)

ANDRADE, DAVID C.; TOLEDO, CAMILO; DIAZ, HUGO S.; LUCERO, CLAUDIA; ARCE-ALVAREZ, ALEXIS; OLIVEIRA, LUIZ M.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.; SCHULTZ, HAROLD D.; MARCUS, NOAH J.; et al. Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure. Clinical Science, v. 133, n. 3, p. 393-405, FEB 14 2019. (15/23376-1, 16/23281-3)

ZOCCAL, DANIEL B.; SILVA, JOSIANE N.; BARNETT, WILLIAM H.; LEMES, EDUARDO V.; FALQUETTO, BARBARA; COLOMBARI, EDUARDO; MOLKOV, YAROSLAV I.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Interaction between the retrotrapezoid nucleus and the parafacial respiratory group to regulate active expiration and sympathetic activity in rats. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, v. 315, n. 5, p. L891-L909, NOV 2018. (14/22406-1, 13/17251-6, 15/23376-1, 16/23281-3, 09/54888-7, 16/22069-0)

DIAZ, HUGO S.; ANDRADE, DAVID C.; TOLEDO, CAMILO; PEREYRA, V, KATHERIN; SCHWARZ, KARLA G.; DIAZ-JARA, ESTEBAN; LUCERO, CLAUDIA; ARCE-ALVAREZ, ALEXIS; SCHULTZ, HAROLD D.; SILVA, JOSIANE N.; et al. Episodic stimulation of central chemoreceptor neurons elicits disordered breathing and autonomic dysfunction in volume overload heart failure. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, v. 318, n. 1, p. L27-L40, JAN 2020. (16/22069-0, 15/23376-1, 16/23281-3)

OLIVEIRA, LUIZ M.; HENRIQUE, ELISANDRA; BUSTELLI, ISABELLA B.; NETTO, NELSON F. C.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.; CAETANO, ARIADINY L.. Depletion of hypothalamic hypocretin/orexin neurons correlates with impaired memory in a Parkinson's disease animal model. Experimental Neurology, v. 323, JAN 2020. (17/20420-5, 16/23281-3, 17/12266-6, 15/23376-1, 15/18842-3)

SHI, YINGTANG; SOBRINHO, CLEYTON R.; SOTO-PEREZ, JASEPH; MILLA, BRENDA M.; STORNETTA, DANIEL S.; STORNETTA, RUTH L.; TAKAKURA, ANA C.; MULKEY, DANIEL K.; MOREIRA, THIAGO S.; BAYLISS, DOUGLAS A.. 5-HT7 receptors expressed in the mouse parafacial region are not required for respiratory chemosensitivity. JOURNAL OF PHYSIOLOGY-LONDON, v. 600, n. 11, p. 23-pg., 2022-04-21. (15/23376-1, 19/01236-4)

SILVA, JOSIANE DO N.; OLIVEIRA, LUIZ M.; SOUZA, FELIPE C.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. GABAergic neurons of the medullary raphe regulate active expiration during hypercapnia. Journal of Neurophysiology, v. 123, n. 5, p. 1933-1943, MAY 2020. (15/23376-1, 16/23281-3, 14/23418-3)

MIRANDA, NICOLE C.; OLIVEIRA, LUIZ M.; AQUINO, YASMIN C.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. The Pedunculopontine Tegmental Nucleus is not Important for Breathing Impairments Observed in a Parkinson?s Disease Model. Neuroscience, v. 512, p. 15-pg., 2023-01-27. (19/01236-4, 15/23376-1, 20/16320-8)

MOREIRA, THIAGO S.; BARRETO-FILHO, JOSE A.; SEABRA-GARCEZ, JULIANE D.; GARCEZ, FLAVIA BARRETO; DRAGER, LUCIANO F.. Last Word on Viewpoint: Nondyspnogenic acute hypoxemic respiratory failure in COVID-19 pneumonia-Breathing pattern in patients with SARS-CoV-2. Journal of Applied Physiology, v. 130, n. 3, p. 900, MAR 2021. (15/23376-1)

MALHEIROS-LIMA, MILENE R.; SILVA, TALITA M.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. 5 noradrenergic-projecting C1 neurons activate sympathetic and breathing outputs in anaesthetized rat. Experimental Physiology, v. 107, n. 2, DEC 2021. (17/08696-5, 19/01236-4, 15/23376-1)

OLIVEIRA, LUIZ M.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. Forebrain and Hindbrain Projecting-neurons Target the Post-inspiratory Complex Cholinergic Neurons. Neuroscience, v. 476, p. 102-115, NOV 10 2021. (15/23376-1, 19/09323-3, 19/01236-4)

SILVA, TALITA M.; BORNIGER, JEREMY C.; ALVES, MICHELE JOANA; CORREA, DIEGO ALZATE; ZHAO, JING; FADDA, PAOLO; TOLAND, AMANDA EWART; TAKAKURA, ANA C.; MOREIRA, THIAGO S.; CZEISLER, CATHERINE M.; et al. Machine learning approaches reveal subtle differences in breathing and sleep fragmentation in Phox2b-derived astrocytes ablated mice. Journal of Neurophysiology, v. 125, n. 4, p. 1164-1179, APR 2021. (15/23376-1, 18/03994-0, 19/01236-4)

FERNANDES-JUNIOR, SILVIO A.; OLIVEIRA, LUIZ M.; CZEISLER, CATHERINE M.; MO, XIAOKUI; ROY, SASHWATI; SOMOGYI, ARPAD; ZHANG, LIEWN; MOREIRA, THIAGO S.; OTERO, JOSE J.; TAKAKURA, ANA C.. Stimulation of retrotrapezoid nucleus Phox2b-expressing neurons rescues breathing dysfunction in an experimental Parkinson's disease rat model. Brain Pathology, v. 30, n. 5, JUL 2020. (16/23281-3, 14/20695-6, 15/23376-1, 17/11165-1)

SILVA, TALITA M.; WASINSKI, FREDERICK; FLOR, KARINE C.; LIST, EDWARD O.; KOPCHICK, JOHN J.; TAKAKURA, ANA C.; DONATO JR, JOSE; MOREIRA, THIAGO S.. The effect of central growth hormone action on hypoxia ventilatory response in conscious mice. Brain Research, v. 1791, p. 10-pg., 2022-07-01. (16/20897-3, 20/01318-8, 15/23376-1, 18/13707-9)

SOBRINHO, C. R.; MILLA, B. M.; SOTO-PEREZ, J.; MOREIRA, T. S.; MULKEY, D. K.. Histamine/H1 receptor signaling in the parafacial region increases activity of chemosensitive neurons and respiratory activity in rats. Journal of Neurophysiology, v. 128, n. 1, p. 11-pg., 2022-07-01. (15/23376-1, 16/23077-7, 15/12827-2)

DE LA ROSA, TOMAS; CALVO, VIVIAM S.; GONCALVES, VALERIA C.; FERREIRA, CAROLINE B.; CABRAL, LAIS M.; SOUZA, FELIPE DA COSTA; SCERNI, DEBORA A.; SCORZA, FULVIO A.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Respiratory deficits in a female rat model of Parkinson's disease. Experimental Physiology, v. 107, n. 11, p. 11-pg., 2022-09-08. (15/23376-1, 19/01236-4)

MORETTI, EDUARDO H.; RODRIGUES, ABNER C.; MARQUES, BRUNO V.; TOTOLA, LEONARDO T.; FERREIRA, CAROLINE B.; BRITO, CAMILA F.; MATOS, CAROLINE M.; DA SILVA, FILIPE A.; SANTOS, ROBSON A. S.; LOPES, LUCIANA B.; et al. Autoregulation of blood flow drives early hypotension in a rat model of systemic inflammation induced by bacterial lipopolysaccharide. PNAS NEXUS, v. 2, n. 2, p. 13-pg., 2023-02-01. (18/13877-1, 20/00631-4, 18/03418-0, 20/09399-7, 15/23376-1, 18/21934-5)

OLIVEIRA, LUIZ M.; SEVERS, LIZA; MOREIRA, THIAGO S.; RAMIREZ, JAN-MARINO; TAKAKURA, ANA C.. Ampakine CX614 increases respiratory rate in a mouse model of Parkinson's disease. Brain Research, v. 1815, p. 6-pg., 2023-06-13. (19/09323-3, 19/01236-4, 15/23376-1, 17/12266-6)

OLIVEIRA, LUIZ M.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Raphe Pallidus is Not Important to Central Chemoreception in a Rat Model of Parkinson's Disease. Neuroscience, v. 369, p. 350-362, JAN 15 2018. (15/18842-3, 16/23281-3, 14/22406-1, 15/23376-1)

FALQUETTO, BARBARA; OLIVEIRA, LUIZ M.; TAKAKURA, ANA C.; MULKEY, DANIEL K.; MOREIRA, THIAGO S.. Inhibition of the hypercapnic ventilatory response by adenosine in the retrotrapezoid nucleus in awake rats. Neuropharmacology, v. 138, p. 47-56, AUG 2018. (15/23376-1, 16/23281-3, 16/22069-0)

OLIVEIRA, LUIZ M.; FALQUETTO, BARBARA; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Orexinergic neurons are involved in the chemosensory control of breathing during the dark phase in a Parkinson's disease model. Experimental Neurology, v. 309, p. 107-118, NOV 2018. (16/23281-3, 16/22069-0, 17/12266-6, 15/23376-1, 15/18842-3, 15/11268-0)

FALQUETTO, BARBARA; THIEME, KARINA; MALTA, MARILIA B.; ROCHA, KARINA C. E.; TUPPY, MARINA; POTJE, SIMONE R.; ANTONIALI, CRISTINA; RODRIGUES, ALICE C.; MUNHOZ, CAROLINA D.; MOREIRA, THIAGO S.; et al. Oxidative stress in the medullary respiratory neurons contributes to respiratory dysfunction in the 6-OHDA model of Parkinson's disease. JOURNAL OF PHYSIOLOGY-LONDON, v. 598, n. 22, SEP 2020. (19/01236-4, 18/05426-0, 19/00065-1, 18/07087-8, 16/03572-3, 15/23376-1, 15/11268-0)

MALHEIROS-LIMA, MILENE R.; ANTUNES, VAGNER R.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. Hypertension and sympathetic nervous system overactivity rely on the vascular tone of pial vessels of the rostral ventrolateral medulla in spontaneously hypertensive rats. Experimental Physiology, v. 105, n. 1, p. 65-74, JAN 2020. (15/23376-1, 16/23281-3, 16/21991-3, 16/22069-0, 17/08696-5)

LIMA, JANAYNA D.; SOBRINHO, CLEYTON R.; SANTOS, LEONARDO K.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. M4-muscarinic acetylcholine receptor into the pedunculopontine tegmental nucleus mediates respiratory modulation of conscious rats. Respiratory Physiology & Neurobiology, v. 269, NOV 2019. (16/23281-3, 15/23376-1, 15/12827-2, 17/01380-2)

NASCIMENTO, ANDRE L. F.; MEDEIROS, PAMELA O. S.; PEDRAO, LUIZ F. A. T.; QUEIROZ, VITORIA C.; OLIVEIRA, LUIZ M.; NOVAES, LEONARDO S.; CAETANO, ARIADINY L.; MUNHOZ, CAROLINA D.; TAKAKURA, ANA C.; FALQUETTO, BARBARA. Oxidative Stress Inhibition Via Apocynin Prevents Medullary Respiratory Neurodegeneration and Respiratory Pattern Dysfunction in a 6-Hydroxydopamine Animal Model of Parkinson's Disease. Neuroscience, v. 502, p. 16-pg., 2022-10-15. (15/23376-1, 19/00065-1, 16/03572-3, 19/01236-4)

CLEARY, COLIN M.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.; NELSON, MARK T.; LONGDEN, THOMAS A.; MULKEY, DANIEL K.. Vascular control of the CO2/H+-dependent drive to breathe. eLIFE, v. 9, p. 23-pg., 2020-09-14. (16/23281-3, 15/23376-1)

MAIA, OCTAVIO A. C.; MALHEIROS-LIMA, MILENE R.; OLIVEIRA, MARIA A.; CASTRO, CLAUDIO L.; MORIYA, HENRIQUE T.; TAVARES-DE-LIMA, WOTHAN; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. Pilocarpine-induced status epilepticus reduces chemosensory control of breathing. Brain Research Bulletin, v. 161, p. 98-105, AUG 2020. (15/23376-1, 16/23281-3, 17/08696-5)

CABRAL, LAIS M.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.; FALQUETTO, BARBARA. Attenuated baroreflex in a Parkinson's disease animal model coincides with impaired activation of non-C1 neurons. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, v. 225, MAY 2020. (15/11268-0, 16/08987-7, 15/23376-1, 16/23281-3)

SILVA, JOSIANE N.; OLIVEIRA, LUIZ M.; SOUZA, FELIPE C.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Distinct pathways to the parafacial respiratory group to trigger active expiration in adult rats. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, v. 317, n. 3, p. L402-L413, SEP 2019. (15/23376-1, 16/23281-3, 14/23418-3)

AQUINO, YASMIN C.; CABRAL, LAIS M.; MIRANDA, NICOLE C.; NACCARATO, MONIQUE C.; FALQUETTO, BARBARA; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Respiratory disorders of Parkinson's disease. Journal of Neurophysiology, v. 127, n. 1, p. 1-15, JAN 2022. (15/23376-1, 20/16320-8, 19/00065-1, 19/01236-4)

CZEISLER, CATHERINE M.; SILVA, TALITA M.; FAIR, SUMMER R.; LIU, JILLIAN; TUPAL, SRINIVASAN; KAYA, BEHIYE; COWGILL, AARON; MAHAJAN, SALIL; SILVA, PHELIPE E.; WANG, YANGYANG; et al. The role of PHOX2B-derived astrocytes in chemosensory control of breathing and sleep homeostasis. JOURNAL OF PHYSIOLOGY-LONDON, v. 597, n. 8, p. 2225-2251, APR 15 2019. (15/23376-1, 16/23281-3, 16/22069-0)

SILVA, TALITA M.; CHAAR, LAIALI J.; SILVA, REINALDO C.; TAKAKURA, ANA C.; CAMARA, NIELS O.; ANTUNES, VAGNER R.; MOREIRA, THIAGO S.. Minocycline alters expression of inflammatory markers in autonomic brain areas and ventilatory responses induced by acute hypoxia. Experimental Physiology, v. 103, n. 6, p. 884-895, JUN 1 2018. (15/23376-1, 16/23281-3, 16/22069-0, 16/21991-3, 13/00401-5)

JAMES, S. D.; HAWKINS, V. E.; FALQUETTO, B.; RUSKIN, D. N.; MASINO, S. A.; MOREIRA, T. S.; OLSEN, M. L.; MULKEY, D. K.. Adenosine Signaling through A1 Receptors Inhibits Chemosensitive Neurons in the Retrotrapezoid Nucleus. ENEURO, v. 5, n. 6, NOV-DEC 2018. (14/04866-5, 15/23376-1, 16/22069-0)

LIMA, JULIANA C.; OLIVEIRA, LUIZ M.; BOTELHO, MARINA T.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. The involvement of the pathway connecting the substantia nigra, the periaqueductal gray matter and the retrotrapezoid nucleus in breathing control in a rat model of Parkinson's disease. Experimental Neurology, v. 302, p. 46-56, APR 2018. (14/22406-1, 16/23281-3, 15/23376-1, 15/18842-3, 13/00103-4)

TOLEDO, CAMILO; ANDRADE, DAVID C.; DIAZ, HUGO S.; PEREYRA, KATHERIN V.; SCHWARZ, KARLA G.; DIAZ-JARA, ESTEBAN; OLIVEIRA, LUIZ M.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.; SCHULTZ, HAROLD D.; et al. Rostral ventrolateral medullary catecholaminergic neurones mediate irregular breathing pattern in volume overload heart failure rats. JOURNAL OF PHYSIOLOGY-LONDON, v. 597, n. 24, NOV 2019. (15/23376-1, 16/23281-3)

LIMA, JANAYNA D.; SOBRINHO, CLEYTON R.; FALQUETTO, BARBARA; SANTOS, LEONARDO K.; TAKAKURA, ANA C.; MULKEY, DANIEL K.; MOREIRA, THIAGO S.. Cholinergic neurons in the pedunculopontine tegmental nucleus modulate breathing in rats by direct projections to the retrotrapezoid nucleus. JOURNAL OF PHYSIOLOGY-LONDON, v. 597, n. 7, p. 1919-1934, APR 2019. (15/23376-1, 16/23281-3, 15/12827-2, 16/22069-0, 17/01380-2)

TAKAKURA, ANA C.; MALHEIROS-LIMA, MILENE R.; MOREIRA, THIAGO S.. Excitatory and inhibitory modulation of parafacial respiratory neurons in the control of active expiration. Respiratory Physiology & Neurobiology, v. 289, JUL 2021. (17/08696-5, 19/01236-4, 15/23376-1)

OLIVEIRA, LUIZ M.; BAERTSCH, NATHAN A.; MOREIRA, THIAGO S.; RAMIREZ, JAN-MARINO; TAKAKURA, ANA C.. Unraveling the Mechanisms Underlying Irregularities in Inspiratory Rhythm Generation in a Mouse Model of Parkinson's Disease. JOURNAL OF NEUROSCIENCE, v. 41, n. 21, p. 4732-4747, MAY 26 2021. (15/23376-1, 19/09323-3, 19/01236-4)

FERREIRA, CAROLINE B.; SILVA, TALITA M.; SILVA, PHELIPE E.; CASTRO, CLAUDIO L.; CZEISLER, CATHERINE; OTERO, JOSE J.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. Phox2b mutation mediated by Atoh1 expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapnia. eLIFE, v. 11, p. 23-pg., 2022-11-17. (15/23376-1)

MOREIRA, THIAGO S.; SHI, YINGTANG; SOBRINHO, CLEYTON R.; MILLA, BRENDA M.; SOTA-PEREZ, JASEPH; STORNETTA, DANIEL S.; STORNETTA, RUTH L.; TAKAKURA, ANA C.; MULKEY, DANIEL K.; BAYLISS, DOUGLAS A.. 5-HT7 receptors expressed in the mouse parafacial region are not required for respiratory chemosensitivity. FASEB JOURNAL, v. 36, p. 1-pg., 2022-01-01. (19/01236-4, 15/23376-1)

OLIVEIRA, LUIZ M.; FERNANDES-JUNIOR, SILVIO A.; CABRAL, LAIS M. C.; MIRANDA, NICOLE C. S.; CZEISLER, CATHERINE M.; OTERO, JOSE J.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Regulation of blood vessels by ATP in the ventral medullary surface in a rat model of Parkinson's disease. Brain Research Bulletin, v. 187, p. 17-pg., 2022-07-12. (15/23376-1, 17/11165-1, 19/09323-3, 14/20695-6, 19/01236-4)

ALZATE-CORREA, DIEGO; LIU, JILLIAN MEI-LING; JONES, MIKAYLA; SILVA, TALITA M.; ALVES, MICHELE JOANA; BURKE, ELIZABETH; ZUNIGA, JESSICA; KAYA, BEHIYE; ZAZA, GIULIANA; ASLAN, MEHMET TAHIR; et al. Neonatal apneic phenotype in a murine congenital central hypoventilation syndrome model is induced through non-cell autonomous developmental mechanisms. Brain Pathology, v. 31, n. 1, AUG 2020. (15/23376-1, 16/23281-3)

MOREIRA, THIAGO S.; TAKAKURA, ANA C.; COLOMBARI, EDUARDO. Editorial: Integrative Physiology: Systemic Hypertension and Respiratory-Sympathetic Coupling. FRONTIERS IN PHYSIOLOGY, v. 13, p. 3-pg., 2022-01-26. (15/23376-1, 15/23467-7, 19/01236-4)