FAPESP/MMV/DNDi/UNICAMP/USP Consortium to discover new drugs for the treatment of tropical parasitic diseases

• Grant number: 15/50655-9
• Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE
• Start date: January 01, 2020
• End date: December 31, 2025
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Luiz Carlos Dias
• Grantee: Luiz Carlos Dias
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• City of the host institution: Campinas
• Partner institutions: Medicines for Malaria Venture
• Principal investigators: Leonardo Luiz Gomes Ferreira
• Associated scholarship(s): 24/03676-0 - Drug discovery of pre-clinical candidates for Chagas Disease, BP.PD; 24/00815-9 - Development of preclinical candidates for the treatment of malaria within the scope of the MINDI consortium, BP.PD; 23/15953-5 - Development of pre-clinical candidates for the treatment of Chagas Disease within the scope of the MINDI consortium, BP.PD; + associated scholarships 23/12973-5 - Development of preclinical candidates for the treatment of malaria within the scope of the MINDI consortium, BP.PD; 23/10723-1 - Drug discovery of pre-clinical candidates for Chagas Disease, BP.PD; 23/10724-8 - Drug discovery of pre-clinical candidates for Chagas Disease, BP.PD; 22/11772-3 - Drug discovery of a pre-clinical candidate for malaria, BP.PD; 22/10577-2 - Drug discovery of pre-clinical candidates for Chagas Disease at the MINDI consortium, BP.PD; 22/10574-3 - Drug discovery of pre-clinical candidates for Chagas Disease, BP.PD; 21/02761-5 - Drug discovery for the treatment of Chagas Disease within the MINDI Consortium, BP.PD; 20/14429-2 - Discovery of plasmodium inhibitors as clinical candidates to treat Malaria, BP.PD; 20/10493-8 - Synthesis of compounds for the treatment of Chagas Disease within the MINDI consortium, BP.PD; 20/10494-4 - Drug discovery in the fight against Malaria, BP.PD - associated scholarships

Abstract

We propose to establish a FAPESP/MMV/DNDi/UNICAMP/USP consortium with the ultimate goal to discover novel drug candidates for clinical development. To this end, the consortium will place high priority on selecting team members from the state of Sao Paulo with a proven track record of high quality research. This group will work in collaboration with expert scientists from the Drugs for Neglected Diseases initiative (DNDi, www.dndi.org) and Medicines for Malaria Venture (MMV, www.mmv.org) and have access to a very well organized framework providing an integrated approach to modern drug discovery. The overall goal with MMV is to deliver a clinical candidate to treat malaria, as defined by the criteria for an MMV Preclinical candidate. Such a compound should have the potential to be developed, in combination, to deliver a Single Exposure Radical Cure and Prophylaxis or single exposure chemoprotection drug. (AU)

Scientific publications

(13)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RAMON GUERRA DE OLIVEIRA; LUIZA DOS REIS CRUZ; LUIZ CARLOS DIAS. ARTEMISININA E DERIVADOS: DESCOBERTA, ESTRATÉGIAS SINTÉTICAS E OBTENÇÃO INDUSTRIAL. Química Nova, v. 45, n. 7, p. 831-846, 2022-09-26. (18/24344-4, 15/50655-9, 13/07600-3)

KOOVITS, PAUL J.; DESSOY, MARCO A.; MATHEEUSSEN, AN; MAES, LOUIS; CALJON, GUY; FERREIRA, LEONARDO L. G.; CHELUCCI, RAFAEL C.; MICHELAN-DUARTE, SIMONE; ANDRICOPULO, ADRIANO D.; CAMPBELL, SIMON; et al. Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents. RSC MEDICINAL CHEMISTRY, v. 11, n. 11, p. 1267-1274, NOV 1 2020. (15/50655-9, 15/19495-5, 13/07600-3)

OLIVEIRA, DOUGLAS DAVISON DA SILVA; SILVA, NAGELA BERNADELLI SOUSA; LAPIERRE, THIBAULT JOSEPH WILLIAM JACQUES DIT; DE SOUZA, SARA LEMES; BRITO, NICOLAS PETERSON FERREIRA; MARTINHO, ANA CLARA CASSIANO; DIAS, RENIEIDY FLAVIA CLEMENTE; FARAGO, DANILO NASCIMENTO; MICHELAN-DUARTE, SIMONE; CHELUCCI, RAFAEL CONSOLIN; et al. Discovery of Arylpiperazines with Broad-Spectrum Antimicrobial Activity and Favorable Pharmacokinetic Profiles. CHEMISTRY & BIODIVERSITY, v. N/A, p. 14-pg., 2024-11-07. (15/50655-9, 18/14268-9, 13/07600-3)

DE OLIVEIRA REZENDE JR, CELSO; MARTINEZ, PABLO DAVID GRIGOL; FERREIRA, RAFAEL AUGUSTO ALVES; KOOVITS, PAUL JOHN; SOARES, BRUNA MIRANDA; FERREIRA, LEONARDO L. G.; MICHELAN-DUARTE, SIMONE; CHELUCCI, RAFAEL CONSOLIN; ANDRICOPULO, ADRIANO D.; MATHEEUSSEN, AN; et al. Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 246, p. 10-pg., 2023-01-15. (13/07600-3, 15/50655-9, 15/09080-2)

ESPINOZA-CHAVEZ, ROCIO MARISOL; REZENDE JUNIOR, CELSO DE OLIVEIRA; DE SOUZA, MARIANA LAUREANO; CHELUCCI, RAFAEL CONSOLIN; MICHELAN-DUARTE, SIMONE; KROGH, RENATA; FERREIRA, LEONARDO LUIZ GOMES; VALLI, MARILIA; DE OLIVEIRA, ALDO SENA; ANDRICOPULO, ADRIANO D.; et al. Structure-Metabolism Relationships of Benzimidazole Derivatives with anti-Trypanosoma cruzi Activity for Chagas Disease. CHEMMEDCHEM, v. 19, n. 20, p. 21-pg., 2024-08-27. (18/14268-9, 13/25658-9, 20/11967-3, 14/50926-0, 19/05967-3, 15/50655-9, 22/08333-8, 13/07600-3, 15/09080-2)

KOOVITS, PAUL J.; DESSOY, MARCO A.; MATHEEUSSEN, AN; MAES, LOUIS; CALJON, GUY; MOWBRAY, CHARLES E.; KRATZ, JADEL M.; DIAS, LUIZ C.. Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi. Bioorganic & Medicinal Chemistry Letters, v. 30, n. 1, JAN 1 2020. (13/07600-3, 15/50655-9, 15/19495-5)

ALVES FERREIRA, RAFAEL AUGUSTO; REZENDE JUNIOR, CELSO DE OLIVEIRA; GRIGOL MARTINEZ, PABLO DAVID; KOOVITS, PAUL JOHN; SOARES, BRUNA MIRANDA; FERREIRA, LEONARDO L. G.; MICHELAN-DUARTE, SIMONE; CHELUCCI, RAFAEL CONSOLIN; ANDRICOPULO, ADRIANO D.; GALUPPO, MARIANA K.; et al. 2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profiling. PLoS Neglected Tropical Diseases, v. 15, n. 2, FEB 2021. (15/09080-2, 15/50655-9, 13/07600-3)

VARELA, MARINA T.; DIAS, GLEISTON G.; DE OLIVEIRA, LUIZ FERNANDO N.; DE OLIVEIRA, RAMON G.; AGUIAR, FRANCIELLE D.; NOGUEIRA, JOAO PEDRO; CRUZ, LUIZA R.; DIAS, LUIZ C.. Spirocyclic compounds as innovative tools in drug discovery for medicinal chemists. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 287, p. 23-pg., 2025-04-05. (22/13110-8, 15/50655-9, 22/10577-2, 23/10723-1, 18/24344-4, 23/10715-9)

MAZUCATO, VITOR DE SOUZA; TONANI, LUDMILLA; VON ZESKA KRESS, MARCIA REGINA; ANDRICOPULO, ADRIANO DEFINI; BARBOSA, GISELE; KROGH, RENATA; GOMES FERREIRA, LEONARDO LUIZ; VIEIRA, PAULO CEZAR. Co-cultivation and Medium Optimization: A Strategy for Discovering Fungal-derived Protease Inhibitors. CHEMISTRY & BIODIVERSITY, v. N/A, p. 10-pg., 2025-09-02. (18/14268-9, 13/07600-3, 23/15953-5, 23/12463-7, 15/50655-9)

KUMAR, MALKEET; AHMAD, ANEES; AGUIAR, ANNA CAROLINE CAMPOS; MALUF, SARAH EL CHAMY; SHAMIM, ANWAR; FERRER, MARIANA; SOUZA, GUILHERME E.; GAZARINI, MARCOS L.; PEREIRA, DHELIO B.; VON GELDERN, THOMAS W.; et al. Indole-2-carboxamides Optimization for Antiplasmodial Activity. ACS BIO & MED CHEM AU, v. N/A, p. 19-pg., 2025-07-31. (13/07600-3, 24/04805-8, 15/50655-9, 19/19708-0, 20/10494-4)

DE OLIVEIRA ALMEIDA, GABRIELA; MAZUCATO, VITOR DE SOUZA; TONANI, LUDMILLA; VON ZESKA KRESS, MARCIA REGINA; BARBOSA, GISELE; KROGH, RENATA; ANDRICOPULO, ADRIANO DEFINI; GOMES FERREIRA, LEONARDO LUIZ; VIEIRA, PAULO CEZAR. Exploring Bioactive Metabolites From Fusarium falciforme and Aspergillus terreus Isolated From Protease-Rich Fruits: Antifungal, Antitrypanosomal, and Enzymatic Inhibitory Activities. CHEMISTRY & BIODIVERSITY, v. N/A, p. 12-pg., 2025-07-20. (24/01273-5, 13/07600-3, 18/14268-9, 15/50655-9, 23/15953-5)

MOLLO, MARIA C.; CAMBIASO, MARIANA L.; FERREIRA, LEONARDO L. G.; KILIMCILER, NATALIA B.; BISCEGLIA, JUAN A.; ANDRICOPULO, ADRIANO D.; ORELLI, LILIANA R.. Synthesis and in vitro leishmanicidal activity of novel Narylspermidine derivatives. BIOORGANIC CHEMISTRY, v. 154, p. 8-pg., 2024-12-24. (13/25658-9, 13/07600-3, 15/50655-9, 18/14268-9)

ESPINOZA-CHAVEZ, ROCIO MARISOL; DE OLIVEIRA REZENDE JR, CELSO; DE SOUZA, MARIANA LAUREANO; PAULI, IVANI; VALLI, MARILIA; FERREIRA, LEONARDO LUIZ GOMES; CHELUCCI, RAFAEL CONSOLIN; MICHELAN-DUARTE, SIMONE; KROGH, RENATA; DA SILVA, FERNANDO BEZERRA ROMUALDO; et al. Structure-activity relationships of novel N-imidazoylpiperazines with potent anti-Trypanosoma cruzi activity. Future Medicinal Chemistry, v. 16, n. 3, p. 18-pg., 2024-01-09. (15/50655-9, 13/07600-3, 15/09080-2)