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FAPESP/MMV/DNDi/UNICAMP/USP Consortium to discover new drugs for the treatment of tropical parasitic diseases

Abstract

We propose to establish a FAPESP/MMV/DNDi/UNICAMP/USP consortium with the ultimate goal to discover novel drug candidates for clinical development. To this end, the consortium will place high priority on selecting team members from the state of Sao Paulo with a proven track record of high quality research. This group will work in collaboration with expert scientists from the Drugs for Neglected Diseases initiative (DNDi, www.dndi.org) and Medicines for Malaria Venture (MMV, www.mmv.org) and have access to a very well organized framework providing an integrated approach to modern drug discovery. The overall goal with MMV is to deliver a clinical candidate to treat malaria, as defined by the criteria for an MMV Preclinical candidate. Such a compound should have the potential to be developed, in combination, to deliver a Single Exposure Radical Cure and Prophylaxis or single exposure chemoprotection drug. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
An agenda for forgotten diseases 
Articles published in Agência FAPESP Newsletter about the research grant:
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VEICULO: TITULO (DATA)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALVES FERREIRA, RAFAEL AUGUSTO; REZENDE JUNIOR, CELSO DE OLIVEIRA; GRIGOL MARTINEZ, PABLO DAVID; KOOVITS, PAUL JOHN; SOARES, BRUNA MIRANDA; FERREIRA, LEONARDO L. G.; MICHELAN-DUARTE, SIMONE; CHELUCCI, RAFAEL CONSOLIN; ANDRICOPULO, ADRIANO D.; GALUPPO, MARIANA K.; ULIANA, SILVIA R. B.; MATHEEUSSEN, AN; CALJON, GUY; MAES, LOUIS; CAMPBELL, SIMON; KRATZ, JADEL M.; MOWBRAY, CHARLES E.; DIAS, LUIZ CARLOS. 2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profiling. PLoS Neglected Tropical Diseases, v. 15, n. 2 FEB 2021. Web of Science Citations: 0.
KOOVITS, PAUL J.; DESSOY, MARCO A.; MATHEEUSSEN, AN; MAES, LOUIS; CALJON, GUY; FERREIRA, LEONARDO L. G.; CHELUCCI, RAFAEL C.; MICHELAN-DUARTE, SIMONE; ANDRICOPULO, ADRIANO D.; CAMPBELL, SIMON; KRATZ, JADEL M.; MOWBRAY, CHARLES E.; DIAS, LUIZ C. Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents. RSC MEDICINAL CHEMISTRY, v. 11, n. 11, p. 1267-1274, NOV 1 2020. Web of Science Citations: 0.
KOOVITS, PAUL J.; DESSOY, MARCO A.; MATHEEUSSEN, AN; MAES, LOUIS; CALJON, GUY; MOWBRAY, CHARLES E.; KRATZ, JADEL M.; DIAS, LUIZ C. Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi. Bioorganic & Medicinal Chemistry Letters, v. 30, n. 1 JAN 1 2020. Web of Science Citations: 0.
ROSSINI, ALLAN F. C.; DIAS, LUIZ C. Synthesis of the C(7)-C(20) Fragment of Spirotoamides A, B and C. Journal of the Brazilian Chemical Society, v. 30, n. 8, p. 1567-1578, AUG 2019. Web of Science Citations: 0.
MARTINEZ, PABLO D. G.; KRAKE, SUSANN H.; POGGI, MAITIA L.; CAMPBELL, SIMON F.; WILLIS, PAUL A.; DIAS, LUIZ C. 2,3,8-Trisubstituted Quinolines with Antimalarial Activity. Anais da Academia Brasileira de Ciências, v. 90, n. 2, p. 1215-1231, 2018. Web of Science Citations: 1.
PABLO D.G. MARTINEZ; SUSANN H. KRAKE; MAITIA L. POGGI; SIMON F. CAMPBELL; PAUL A. WILLIS; LUIZ C. DIAS. 2,3,8-Trisubstituted Quinolines with Antimalarial Activity. Anais da Academia Brasileira de Ciências, v. 90, n. 1, p. -, 2018.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.