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FAPESP/MMV/DNDi/UNICAMP/USP Consortium to discover new drugs for the treatment of tropical parasitic diseases

Grant number: 15/50655-9
Support type:Research Grants - Research Partnership for Technological Innovation - PITE
Duration: December 01, 2016 - November 30, 2021
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Luiz Carlos Dias
Grantee:Luiz Carlos Dias
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Company: Medicines for Malaria Venture
City: Campinas


We propose to establish a FAPESP/MMV/DNDi/UNICAMP/USP consortium with the ultimate goal to discover novel drug candidates for clinical development. To this end, the consortium will place high priority on selecting team members from the state of Sao Paulo with a proven track record of high quality research. This group will work in collaboration with expert scientists from the Drugs for Neglected Diseases initiative (DNDi, and Medicines for Malaria Venture (MMV, and have access to a very well organized framework providing an integrated approach to modern drug discovery. The overall goal with MMV is to deliver a clinical candidate to treat malaria, as defined by the criteria for an MMV Preclinical candidate. Such a compound should have the potential to be developed, in combination, to deliver a Single Exposure Radical Cure and Prophylaxis or single exposure chemoprotection drug. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROSSINI, ALLAN F. C.; DIAS, LUIZ C. Synthesis of the C(7)-C(20) Fragment of Spirotoamides A, B and C. Journal of the Brazilian Chemical Society, v. 30, n. 8, p. 1567-1578, AUG 2019. Web of Science Citations: 0.
PABLO D.G. MARTINEZ; SUSANN H. KRAKE; MAITIA L. POGGI; SIMON F. CAMPBELL; PAUL A. WILLIS; LUIZ C. DIAS. 2,3,8-Trisubstituted Quinolines with Antimalarial Activity. Anais da Academia Brasileira de Ciências, v. 90, n. 1, p. -, 2018.
MARTINEZ, PABLO D. G.; KRAKE, SUSANN H.; POGGI, MAITIA L.; CAMPBELL, SIMON F.; WILLIS, PAUL A.; DIAS, LUIZ C. 2,3,8-Trisubstituted Quinolines with Antimalarial Activity. Anais da Academia Brasileira de Ciências, v. 90, n. 2, p. 1215-1231, 2018. Web of Science Citations: 1.

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