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Clinical-epidemiological study of a cohort of Zika infected pregnant women in São José do Rio Preto, SP


The Zika virus infection epidemic in Brazil is one of the most important challenges of contemporary Brazilian science. The first cases of microcephaly potentially associated with this virus have been reported in northeastern Brazil. Between August and October 2015 dozens of cases of microcephaly and ocular abnormalities were observed in newborns and laboratory tests in their blood and tissues as well as their mothers demonstrated the presence of Zika virus. In this context, it is assumed that the state of São Paulo and especially its regions with large infestation of Aedes aegypti (for example, the region of São José do Rio Preto, in northwestern São Paulo) are not exempt from virus transmission risk Zika and potential clinical complications resulting from infection by this arbovirus. Thus, the aim of this work is to develop a prospective cohort (already in progress) of infected pregnant women in order to evaluate the clinical, virological and epidemiological aspects of Zika infection in pregnant women and their offsprings. In particular we propose: i) verify the incidence of serious outcomes (such as microcephaly) in pregnant women infected with confirmed Zika virus infection and its relationship with periods of infection; ii) to verify the incidence of mild outcomes (not clinically apparent) through imaging methods in children from infected mothers; iii) determine the incidence of congenital infection in fetuses from mothers with confirmed ZIka infection by PCR in cord blood, urine and / or serology in the fetus; iv) Check the relative and absolute risk of minor, serious and virological outcomes; v) In collaboration with other studies, verify the virological, immunological and epidemiological aspects and their relationship with the outcome. The resulting studies of this work can help the SUS implement control policies, surveillance, harm reduction and health planning. (AU)

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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SARIOL, CARLOS A.; NOGUEIRA, MAURICIO L.; VASILAKIS, NIKOS. A Tale of Two Viruses: Does Heterologous Flavivirus Immunity Enhance Zika Disease?. TRENDS IN MICROBIOLOGY, v. 26, n. 3, p. 186-190, . (13/21719-3, 16/15021-1)
TERZIAN, ANA CAROLINA B.; ZINI, NATHALIA; SACCHETTO, LIVIA; ROCHA, REBECA FROES; PEREIRA PARRA, MAISA CARLA; DEL SARTO, JULIANA LEMOS; FIALHO DIAS, ANA CAROLINA; COUTINHO, FELIPE; RAYRA, JESSICA; DA SILVA, RAFAEL ALVES; et al. Evidence of natural Zika virus infection in neotropical non-human primates in Brazil. SCIENTIFIC REPORTS, v. 8, . (13/21719-3, 15/12295-0, 16/15021-1, 14/23159-8)
DAMASCENO, LUANA; TERZIAN, ANA CAROLINA B.; FULLER, TREVON; ESTOFOLETE, CASSIA F.; ANDRADE, ADRIANA; KROON, ERNA G.; ZIN, ANDREA A.; VASCONCELOS, ZILTON; PEREIRA, JR., JOSE P.; CASTILHO, MARCIA C.; et al. Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts. Viruses-Basel, v. 13, n. 5, . (13/21719-3, 15/12295-0, 16/15021-1)
COSTA ALECRIM, MARIA DAS GRACAS; RAMOS DE AMORIM, MELANIA MARIA; BARRETO DE ARAUJO, THALIA VELHO; BRASIL, PATRICIA; BRICKLEY, ELIZABETH B.; CASTILHO, MARCIA DA COSTA; COELHO, BERNADETE PEREZ; LEDO ALVES DA CUNHA, ANTONIO JOSE; DUARTE, GERALDO; ESTOFOLETE, CASSIA FERNANDA; et al. Zika Brazilian Cohorts (ZBC) Consortium: Protocol for an Individual Participant Data Meta-Analysis of Congenital Zika Syndrome after Maternal Exposure during Pregnancy. Viruses-Basel, v. 13, n. 4, . (15/12295-0, 17/21688-1, 16/05115-9, 16/08578-0, 16/15021-1, 13/21719-3)
DA ROCHA, LEONARDO CECILIO; ESTOFOLETE, CASSIA FERNANDA; GONCALVES DE AGUIAR MILHIM, BRUNO HENRIQUE; AUGUSTO, MARCOS TAYAR; ZINI, NATHALIA; DUTRA DA SILVA, GISLAINE CELESTINO; FERRAZ-JUNIOR, HELIO CORREA; SABADOTO BRIENZE, VANIA MARIA; LISO, ELISABETE; CUNHA, MARIANA SEQUETIN; et al. Enteric viruses circulating in undiagnosed central nervous system infections at tertiary hospital in Sao Jose do Rio Preto, Sao Paulo, Brazil. Journal of Medical Virology, v. 93, n. 6, . (13/21719-3, 16/15021-1, 17/00021-9, 15/12295-0)
NOGUEIRA, M. L.; NERY JUNIOR, N. R. R.; ESTOFOLETE, C. F.; BERNARDES TERZIAN, A. C.; GUIMARAES, G. F.; ZINI, N.; ALVES DA SILVA, R.; DUTRA SILVA, G. C.; JUNQUEIRA FRANCO, L. C.; RAHAL, P.; et al. Adverse birth outcomes associated with Zika virus exposure during pregnancy in Sao Jose do Rio Preto, Brazil. Clinical Microbiology and Infection, v. 24, n. 6, p. 646-652, . (13/21719-3, 15/12295-0, 16/05115-9, 16/15021-1)
REN, PING; ORTIZ, DANIEL A.; TERZIAN, ANA C. B.; COLOMBO, TATIANA E.; NOGUEIRA, MAURICIO L.; VASILAKIS, NIKOS; LOEFFELHOLZ, MICHAEL J.. Evaluation of Aptima Zika Virus Assay. Journal of Clinical Microbiology, v. 55, n. 7, p. 2198-2203, . (13/21719-3, 15/12295-0, 16/15021-1)
BOSCH, IRENE; DE PUIG, HELENA; HILEY, MEGAN; CARRE-CAMPS, MARC; PERDOMO-CELIS, FEDERICO; NARVAEZ, CARLOS F.; SALGADO, DORIS M.; SENTHOOR, DEWAHAR; O'GRADY, MADELINE; PHILLIPS, ELIZABETH; et al. Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum. Science Translational Medicine, v. 9, n. 409, . (13/21719-3, 16/15021-1)
TERZIAN, ANA CAROLINA B.; ESTOFOLETE, CASSIA FERNANDA; DA SILVA, RAFAEL ALVES; MOS VAZ-OLIANI, DENISE CRISTINA; OLIANI, ANTONIO HELIO; BRANDAO DE MATTOS, CINARA CASSIA; DE MATTOS, LUIZ CARLOS; RAHAL, PAULA; NOGUEIRA, MAURICIO L.. Long-Term Viruria in Zika Virus-Infected Pregnant Women, Brazil, 2016. Emerging Infectious Diseases, v. 23, n. 11, p. 1891-1893, . (13/21719-3, 15/12295-0, 16/15021-1)

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