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Clinical-epidemiological study of a cohort of Zika infected pregnant women in São José do Rio Preto, SP

Grant number: 16/15021-1
Support type:Research Grants - Research in Public Policies for the National Health Care System (PP-SUS)
Duration: December 01, 2016 - November 30, 2018
Field of knowledge:Biological Sciences - Microbiology
Cooperation agreement: CNPq - PPSUS
Principal Investigator:Maurício Lacerda Nogueira
Grantee:Maurício Lacerda Nogueira
Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil
Assoc. researchers:Cinara de Cássia Brandão de Mattos ; Denise Cristina Mós Vaz Oliani ; Eliana Márcia Sotello Cabrera ; Luiz Carlos de Mattos

Abstract

The Zika virus infection epidemic in Brazil is one of the most important challenges of contemporary Brazilian science. The first cases of microcephaly potentially associated with this virus have been reported in northeastern Brazil. Between August and October 2015 dozens of cases of microcephaly and ocular abnormalities were observed in newborns and laboratory tests in their blood and tissues as well as their mothers demonstrated the presence of Zika virus. In this context, it is assumed that the state of São Paulo and especially its regions with large infestation of Aedes aegypti (for example, the region of São José do Rio Preto, in northwestern São Paulo) are not exempt from virus transmission risk Zika and potential clinical complications resulting from infection by this arbovirus. Thus, the aim of this work is to develop a prospective cohort (already in progress) of infected pregnant women in order to evaluate the clinical, virological and epidemiological aspects of Zika infection in pregnant women and their offsprings. In particular we propose: i) verify the incidence of serious outcomes (such as microcephaly) in pregnant women infected with confirmed Zika virus infection and its relationship with periods of infection; ii) to verify the incidence of mild outcomes (not clinically apparent) through imaging methods in children from infected mothers; iii) determine the incidence of congenital infection in fetuses from mothers with confirmed ZIka infection by PCR in cord blood, urine and / or serology in the fetus; iv) Check the relative and absolute risk of minor, serious and virological outcomes; v) In collaboration with other studies, verify the virological, immunological and epidemiological aspects and their relationship with the outcome. The resulting studies of this work can help the SUS implement control policies, surveillance, harm reduction and health planning. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Pregnant women should be tested more than once for the presence of Zika 
Genetic factors may determine severity of hantavirus infection  
Babies exposed to Zika in a Brazilian city did not have microcephaly 
Articles published in other media outlets (3 total):
Chance de contrair zika pode ser menor para quem já teve dengue 
Chance de contrair zika pode ser menor para quem já teve dengue 
Chance de contrair zika pode ser menor para quem já teve dengue 

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TERZIAN, ANA CAROLINA B.; ZINI, NATHALIA; SACCHETTO, LIVIA; ROCHA, REBECA FROES; PEREIRA PARRA, MAISA CARLA; DEL SARTO, JULIANA LEMOS; FIALHO DIAS, ANA CAROLINA; COUTINHO, FELIPE; RAYRA, JESSICA; DA SILVA, RAFAEL ALVES; COSTA, VIVIAN VASCONCELOS; COUTO DE AZEVEDO FERNANDES, NATALIA COELHO; RESSIO, RODRIGO; DIAZ-DELGADO, JOSUE; GUERRA, JULIANA; CUNHA, MARIANA S.; CATAO-DIAS, JOSE LUIZ; BITTAR, CINTIA; NEGRI REIS, ANDREIA FRANCESLI; PENHA DOS SANTOS, IZALCO NUREMBERG; MARASCALCHI FERREIRA, ANDREIA CRISTINA; ARAO ANTONIO CRUZ, LILIAN ELISA; RAHAL, PAULA; ULLMANN, LEILA; MALOSSI, CAMILA; DE ARAUJO, JR., JOAO PESSOA; WIDEN, STEVEN; DE REZENDE, IZABELA MAURICIO; MELLO, ERICA; PACCA, CAROLINA COLOMBELLI; KROON, ERNA GEESSIEN; TRINDADE, GILIANE; DRUMOND, BETANIA; CHIARAVALLOTI-NETO, FRANCISCO; VASILAKIS, NIKOS; TEIXEIRA, MAURO M.; NOGUEIRA, MAURICIO LACERDA. Evidence of natural Zika virus infection in neotropical non-human primates in Brazil. SCIENTIFIC REPORTS, v. 8, OCT 30 2018. Web of Science Citations: 11.
NOGUEIRA, M. L.; NERY JUNIOR, N. R. R.; ESTOFOLETE, C. F.; BERNARDES TERZIAN, A. C.; GUIMARAES, G. F.; ZINI, N.; ALVES DA SILVA, R.; DUTRA SILVA, G. C.; JUNQUEIRA FRANCO, L. C.; RAHAL, P.; BITTAR, C.; CARNEIRO, B.; VASCONCELOS, P. F. C.; FREITAS HENRIQUES, D.; BARBOSA, D. M. U.; LOPES ROMBOLA, P.; DE GRANDE, L.; NEGRI REIS, A. F.; PALOMARES, S. A.; WAKAI CATELAN, M.; CRUZ, L. E. A. A.; NECCHI, S. H.; MENDONCA, R. C. V.; PENHA DOS SANTOS, I. N.; ALAVARSE CARON, S. B.; COSTA, F.; BOZZA, F. A.; SOARES DE SOUZA, A.; BRANDAO DE MATTOS, C. C.; DE MATTOS, L. C.; VASILAKIS, N.; OLIANI, A. H.; VAZ OLIANI, D. C. M.; KO, A. I. Adverse birth outcomes associated with Zika virus exposure during pregnancy in Sao Jose do Rio Preto, Brazil. Clinical Microbiology and Infection, v. 24, n. 6, p. 646-652, JUN 2018. Web of Science Citations: 10.
SARIOL, CARLOS A.; NOGUEIRA, MAURICIO L.; VASILAKIS, NIKOS. A Tale of Two Viruses: Does Heterologous Flavivirus Immunity Enhance Zika Disease?. TRENDS IN MICROBIOLOGY, v. 26, n. 3, p. 186-190, MAR 2018. Web of Science Citations: 11.
TERZIAN, ANA CAROLINA B.; ESTOFOLETE, CASSIA FERNANDA; DA SILVA, RAFAEL ALVES; MOS VAZ-OLIANI, DENISE CRISTINA; OLIANI, ANTONIO HELIO; BRANDAO DE MATTOS, CINARA CASSIA; DE MATTOS, LUIZ CARLOS; RAHAL, PAULA; NOGUEIRA, MAURICIO L. Long-Term Viruria in Zika Virus-Infected Pregnant Women, Brazil, 2016. Emerging Infectious Diseases, v. 23, n. 11, p. 1891-1893, NOV 2017. Web of Science Citations: 5.
BOSCH, IRENE; DE PUIG, HELENA; HILEY, MEGAN; CARRE-CAMPS, MARC; PERDOMO-CELIS, FEDERICO; NARVAEZ, CARLOS F.; SALGADO, DORIS M.; SENTHOOR, DEWAHAR; O'GRADY, MADELINE; PHILLIPS, ELIZABETH; DURBIN, ANN; FANDOS, DIANA; MIYAZAKI, HIKARU; YEN, CHUN-WAN; GELVEZ-RAMIREZ, MARGARITA; WARKE, RAJAS V.; RIBEIRO, LUCAS S.; TEIXEIRA, MAURO M.; ALMEIDA, ROQUE P.; MUNOZ-MEDINA, JOSE E.; LUDERT, JUAN E.; NOGUEIRA, MAURICIO L.; COLOMBO, TATIANA E.; TERZIAN, ANA C. B.; BOZZA, PATRICIA T.; CALHEIROS, ANDREA S.; VIEIRA, YASMINE R.; BARBOSA-LIMA, GISELLE; VIZZONI, ALEXANDRE; CERBINO-NETO, JOSE; BOZZA, FERNANDO A.; SOUZA, THIAGO M. L.; TRUGILHO, MONIQUE R. O.; DE FILIPPIS, ANA M. B.; DE SEQUEIRA, PATRICIA C.; MARQUES, ERNESTO T. A.; MAGALHAES, TEREZA; DIAZ, FRANCISCO J.; RESTREPO, BERTA N.; MARIN, KATERINE; MATTAR, SALIM; OLSON, DANIEL; ASTURIAS, EDWIN J.; LUCERA, MARK; SINGLA, MOHIT; MEDIGESHI, GURUPRASAD R.; DE BOSCH, NORMA; TAM, JUSTINA; GOMEZ-MARQUEZ, JOSE; CLAVET, CHARLES; VILLAR, LUIS; HAMAD-SCHIFFERLI, KIMBERLY; GEHRKE, LEE. Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum. Science Translational Medicine, v. 9, n. 409 SEP 27 2017. Web of Science Citations: 33.
REN, PING; ORTIZ, DANIEL A.; TERZIAN, ANA C. B.; COLOMBO, TATIANA E.; NOGUEIRA, MAURICIO L.; VASILAKIS, NIKOS; LOEFFELHOLZ, MICHAEL J. Evaluation of Aptima Zika Virus Assay. Journal of Clinical Microbiology, v. 55, n. 7, p. 2198-2203, JUL 2017. Web of Science Citations: 10.

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