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VIRAL METAGENOMICS TO TRACK, EXPLAIN AND PREDICT THE TRANSMISSION AND SPATIOTEMPORAL SPREAD OF DENGUE AND CHIKUNGUNYA VIRUSES IN BRAZIL

Grant number: 16/01735-2
Support type:Regular Research Grants
Duration: February 01, 2017 - January 31, 2019
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Ester Cerdeira Sabino
Grantee:Ester Cerdeira Sabino
Home Institution: Instituto de Medicina Tropical de São Paulo (IMT). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Resumo em InglêsBrazil is hyper-endemic for dengue, with over 8 million cases reported between 2000-2015. The transmission and dissemination of the four serotypes of dengue virus (DENV) is reported in the country through the mosquito vector (Aedes aegypti). Besides DENV, other two virus Chikungunya (CHIKV) and Zika (ZIKV) ) have already been introduced in Brazil and has caused severe epidemics, but the situation can be complicated even more as these have not yet started the period of rain. This project is a collaboration between researchers from the Institute of Tropical Medicine (IMT/USP), Oxford University (OU) and the Blood Systems Research Institute (BSRI) in an effort to reconstruct in detail the transmission dynamics of circulating viral strains in Brazil, using epidemiological data and the human host to better understand the pathogenesis of these viruses. The infrastructure already established by the Brazilian team has allowed the collection of individual blood samples from different cities in Brazil that will be included in the project and this project will be recruited other cities, which will allow the collection of isolates from current outbreaks of DENV, CHIKV and ZIKV. The aim of this study is to perform the viral metagenomics of samples collected in several Brazilian cities using next-generation sequencing to elucidate and predict the spatial dynamics and transmission of DENV, CHIKV and ZIKV in Brazil. At least 400 DENV, 200 CHIKV and 200 ZIKV from individuals that total nucleic acids are sequenced, the sequencing order of one or more viruses. The virus that through this approach are not completely sequenced will then be amplified and sequenced the missing parts. The obtained sequences are then subjected to mount "de novo" through a "pipeline" of BSRI for reconstruction of viral genomes, the consensus sequences generated will be submitted to genetic characterization focusing on the identification of transmission networks and viral spread. Then maximum likelihood and Bayesian phylogenetics will be reconstructed to determine the evolutionary relationships of the circulating strains in the national and global contexts. Best fitting nucleotide substitution, molecular clock, and coalescent models will be chosen using harmonic mean estimators, path sampling and stepping stone approaches. Rates of viral lineage movement among populations will be quantified using discrete phylogeographic approaches. Given the latitude and longitude coordinates of each isolate, we will also apply continuous diffusion models and summarize key epidemiological statistics such as dispersal velocity. Coalescent and birth-death skyline models will be used to estimate the rate of epidemic growth through time of different circulating lineages. Rates of synonymous and nonsynonymous changes will be quantified using renaissance counting and more recent algorithms for quantifying molecular adaptation being developed by the Oxford team. Viruses of dengue cases with the worst clinical outcomes will also be sequenced and analysed to see if there is any DENV sequence motif or mutational combination associated with severity. The association between disease severity and mutations will be tested using an association test that takes into account phylogenetic uncertainty. In summary, the study will combine genetic, ecological, clinical, and surveillance data to understand DENV, CHIKV and ZIKV epidemiology as well as DENV-host interactions that underlie disease severity. Ultimately, the research proposed here aims to reduce the burden caused by important arbovirus outbreaks in Brazil, with potential benefits for both public health and vaccine development. (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre o auxílio:
Two novel viruses identified in Brazilian patients with suspected dengue 
The risk of death from yellow fever can be detected sooner 
Yellow fever virus responsible for current epidemic in Brazil originated in the Amazon in 1980 
Virus that infects pigs in China is found in human patient in Brazil 

Scientific publications (23)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HILL, SARAH C.; DE SOUZA, RENATO; THEZE, JULIEN; CLARO, INGRA; AGUIAR, RENATO S.; ABADE, LEANDRO; SANTOS, FABIANA C. P.; CUNHA, MARIANA S.; NOGUEIRA, JULIANA S.; SALLES, FLAVIA C. S.; ROCCO, IRAY M.; MAEDA, ADRIANA Y.; VASAMI, FERNANDA G. S.; DU PLESSIS, LOUIS; SILVEIRA, PAOLA P.; DE JESUS, JAQUELINE G.; QUICK, JOSHUA; FERNANDES, NATALIA C. C. A.; GUERRA, JULIANA M.; RESSIO, RODRIGO A.; GIOVANETTI, MARTA; ALCANTARA, LUIZ C. J.; CIRQUEIRA, CINTHYA S.; DIAZ-DELGADO, JOSUE; MACEDO, FERNANDO L. L.; TIMENETSKY, MARIA DO CARMO S. T.; DE PAULA, REGIANE; SPINOLA, ROBERTA; DE DEUS, JULIANA TELLES; MUCCI, LUIS F.; TUBAKI, ROSA MARIA; DE MENEZES, REGIANE M. T.; RAMOS, PATRICIA L.; DE ABREU, ANDRE L.; CRUZ, LAURA N.; LOMAN, NICK; DELLICOUR, SIMON; PYBUS, OLIVER G.; SABINO, ESTER C.; FARIA, NUNO R. Genomic Surveillance of Yellow Fever Virus Epizootic in Sao Paulo, Brazil, 2016-2018. PLOS PATHOGENS, v. 16, n. 8 AUG 2020. Web of Science Citations: 0.
CUNHA, MARIANA SEQUETIN; FARIA, NUNO RODRIGUES; CALEIRO, GIOVANA SANTOS; CANDIDO, DARLAN SILVA; HILL, SARAH C.; CLARO, INGRA MORALES; DA COSTA, ANTONIO CHARLYS; NOGUEIRA, JULIANA SILVA; MAEDA, ADRIANA YURIKA; DA SILVA, FERNANDA GISELE; DE SOUZA, RENATO PEREIRA; SPINOLA, ROBERTA; TUBAKI, ROSA MARIA; TIRONI DE MENEZES, REGIANE MARIA; ABADE, LEANDRO; MUCCI, LUIS FILIPE; SAMPAIO TAVARES TIMENETSKY, MARIA DO CARMO; SABINO, ESTHER. Genomic evidence of yellow fever virus in Aedes scapularis, southeastern Brazil, 2016. Acta Tropica, v. 205, MAY 2020. Web of Science Citations: 0.
CUNHA, MARIANA SEQUETIN; LUCHS, ADRIANA; DA COSTA, ANTONIO CHARLYS; RIBEIRO, GEOVANI DE OLIVEIRA; PEREIRA DOS SANTOS, FABIANA CRISTINA; NOGUEIRA, JULIANA SILVA; KOMNINAKIS, SHIRLEY VASCONCELOS; SOUZA MARINHO, ROBSON DOS SANTOS; WITKIN, STEVEN S.; VILLANOVA, FABIOLA; DENG, XUTAO; SABINO, ESTER CERDEIRA; DELWART, ERIC; LEAL, ELCIO; NOGUEIRA, MAURICIO LACERDA; MAIORKA, PAULO CESAR. Detection and characterization of Ilheus and Iguape virus genomes in historical mosquito samples from Southern Brazil. Acta Tropica, v. 205, MAY 2020. Web of Science Citations: 0.
TAHMASEBI, ROOZBEH; DA COSTA, ANTONIO CHARLYS; TARDY, KAELAN; TINKER, RORY J.; DE PADUA MILAGRES, FLAVIO AUGUSTO; BRUSTULIN, RAFAEL; RODRIGUES TELES, MARIA DA APARECIDA; DAS CHAGAS, ROGERIO TOGISAKI; DE DEUS ALVES SOARES, CASSIA VITORIA; ARANHA WATANABE, ARIPUANA SAKURADA; ALENCAR, CECILIA SALETE; VILLANOVA, FABIOLA; DENG, XUTAO; DELWART, ERIC; LUCHS, ADRIANA; LEAL, ELCIO; SABINO, ESTER CERDEIRA. Genomic Analyses of Potential Novel Recombinant Human Adenovirus C in Brazil. Viruses-Basel, v. 12, n. 5 MAY 2020. Web of Science Citations: 0.
FAHSBENDER, ELIZABETH; DA-COSTA, ANTONIO CHARLYS; GILL, DANIELLE ELISE; MILAGRES, FLAVIO AUGUSTO DE PADUA; BRUSTULIN, RAFAEL; MONTEIRO, FRED JULIO COSTA; REGO, MARLISSON OCTAVIO DA SILVA; RIBEIRO, EDCELHA SOARES D'ATHAIDE; SABINO, ESTER CERDEIRA; DELWART, ERIC. Plasma virome of 781 Brazilians with unexplained symptoms of arbovirus infection include a novel parvovirus and densovirus. PLoS One, v. 15, n. 3 MAR 5 2020. Web of Science Citations: 0.
JAQUELINE GOES DE JESUS; KARINA ROCHA DUTRA; FLAVIA CRISTINA DA SILVA SALES; INGRA MORALES CLARO; ANA CAROLINA TERZIAN; DARLAN DA SILVA CANDIDO; SARAH C HILL; JULIEN THÉZÉ; CELESTE TORRES; TATIANA LANG D’AGOSTINI; ALVINA CLARA FELIX; ANDREIA F NEGRI REIS; LUIZ CARLOS JUNIOR ALCANTARA; ANDRÉ L DE ABREU; JÚLIO HR CRODA; WANDERSON K DE OLIVEIRA; ANA MARIA BISPO DE FILIPIS; MARIA DO CARMO RODRIGUES DOS SANTOS CAMIS; CAMILA MALTA ROMANO; NICK J LOMAN; OLIVER G PYBUS; ESTER CERDEIRA SABINO; MAURICIO L NOGUEIRA; NUNO RODRIGUES FARIA. Genomic detection of a virus lineage replacement event of dengue virus serotype 2 in Brazil, 2019. Memórias do Instituto Oswaldo Cruz, v. 115, p. -, 2020. Web of Science Citations: 0.
ROSA, ULISSES ALVES; RIBEIRO, GEOVANI DE OLIVEIRA; VILLANOVA, FABIOLA; LUCHS, ADRIANA; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; TAHMASEBI, ROOZBEH; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; BRUSTULIN, RAFAEL; DAS CHAGAS, ROGERIO TOGISAKI; NEVES DOS SANTOS ABRAO, MARIA DE FATIMA; DE DEUS ALVES SOARES, CASSIA VITORIA; TINKER, RORY J.; PANDEY, RAMENDRA PATI; RAJ, V. SAMUEL; SABINO, ESTER CERDEIRA; DENG, XUTAO; DELWART, ERIC; DA COSTA, ANTONIO CHARLYS; LEAL, ELCIO. First identification of mammalian orthoreovirus type 3 by gut virome analysis in diarrheic child in Brazil. SCIENTIFIC REPORTS, v. 9, DEC 9 2019. Web of Science Citations: 0.
FIGUEIREDO-MELLO, CLAUDIA; BOAS CASADIO, LUCIANA VILAS; AVELINO-SILVA, VIVIAN LIDA; YEH-LI, HO; SZTAJNBOK, JAQUES; JOELSONS, DANIEL; ANTONIO, MARILIA BORDIGNON; REBELLO PINHO, JOAO RENATO; MALTA, FERNANDA DE MELLO; GOMES-GOUVEA, MICHELE SOARES; MOREIRA SALLES, ANA PAULA; CORA, ALINE PIVETTA; VALENTE MOREIRA, CARLOS HENRIQUE; RIBEIRO, ANA FREITAS; DE SEIXAS SANTOS NASTRI, ANA CATHARINA; SANT'ANA MALAQUE, CEILA MARIA; AZEVEDO TEIXEIRA, RALCYON FRANCIS; SANSAO BORGES, LUCIANA MARQUES; GONZALEZ, MARIO PERIBANEZ; PEREIRA JUNIOR, LUIZ CARLOS; LOBATO SOUZA, TAMARA NEWMAN; WAN SONG, ALICE TUNG; CARNEIRO D'ALBUQUERQUE, LUIZ AUGUSTO; ABDALA, EDSON; ANDRAUS, WELLINGTON; DE MARTINO, RODRIGO BRONZE; DUCATTI, LILIANA; ANDRADE, GUILHERME MARQUES; SE MALBOUISSON, LUIZ MARCELO; DE SOUZA, IZABEL MARCILIO; CARRILHO, FLAIR JOSE; SABINO, ESTER CERDEIRA; LEVIN, ANNA S. Efficacy of sofosbuvir as treatment for yellow fever: protocol for a randomised controlled trial in Brazil (SOFFA study). BMJ OPEN, v. 9, n. 11 NOV 2019. Web of Science Citations: 0.
DA COSTA, ANTONIO CHARLYS; LEAL, ELCIO; GILL, DANIELLE; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; BRUSTULIN, RAFAEL; RODRIGUES TELES, MARIA DA APARECIDA; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; DAS CHAGAS, ROGERIO TOGISAKI; NEVES DOS SANTOS ABRAO, MARIA DE FATIMA; DE DEUS ALVES SOARES, CASSIA VITORIA; DENG, XUTAO; DELWART, ERIC; SABINO, ESTER CERDEIRA; LUCHS, ADRIANA. Discovery of Cucumis melo endornavirus by deep sequencing of human stool samples in Brazil. VIRUS GENES, v. 55, n. 3, p. 332-338, JUN 2019. Web of Science Citations: 2.
LEAL, ELCIO; LUCHS, ADRIANA; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; GILL, DANIELLE ELISE; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; BRUSTULIN, RAFAEL; DAS CHAGAS, ROGERIO TOGISAKI; NEVES DOS SANTOS ABRAO, MARIA DE FATIMA; DE DEUS ALVES SOARES, CASSIA VITORIA; VILLANOVA, FABIOLA; WITKIN, STEVEN S.; DENG, XUTAO; SABINO, ESTER CERDEIRA; DELWART, ERIC; DA COSTA, ANTONIO CHARLYS. Recombinant Strains of Human Parechovirus in Rural Areas in the North of Brazil. Viruses-Basel, v. 11, n. 6 JUN 2019. Web of Science Citations: 0.
CUNHA, MARIANA SEQUETIN; DA COSTA, ANTONIO CHARLYS; COUTO DE AZEVEDO FERNANDES, NATALIA COELHO; GUERRA, JULIANA MARIOTTI; PEREIRA DOS SANTOS, FABIANA CRISTINA; NOGUEIRA, JULIANA SILVA; D'AGOSTINO, LEANDRO GUARIGLIA; KOMNINAKIS, SHIRLEY VASCONCELOS; WITKIN, STEVEN S.; RESSIO, RODRIGO ALBERGARIA; MAEDA, ADRIANA YURIKA; SILVA VASAMI, FERNANDA GISELE; ABREU KAIGAWA, URSULA MITSUE; DE AZEVEDO, LAIS SAMPAIO; DE SOUZA FACIOLI, PALOMA ALANA; LIMA MACEDO, FERNANDO LUIZ; SABINO, ESTER CERDEIRA; LEAL, ELCIO; DE SOUZA, RENATO PEREIRA. Epizootics due to Yellow Fever Virus in Sao Paulo State, Brazil: viral dissemination to new areas (2016-2017). SCIENTIFIC REPORTS, v. 9, APR 2 2019. Web of Science Citations: 2.
RIBEIRO, GEOVANI DE OLIVEIRA; COSTA MONTEIRO, FRED JULIO; REGO, MARLISSON OCTAVIO DA S.; D'ATHAIDE RIBEIRO, EDCELHA SOARES; DE CASTRO, DANIELA FUNAYAMA; CASEIRO, MARCOS MONTANI; SOUZA MARINHO, ROBSON DOS SANTOS; KOMNINAKIS, SHIRLEY VASCONCELOS; WITKIN, STEVEN S.; DENG, XUTAO; DELWART, ERIC; SABINO, ESTER CERDEIRA; DA COSTA, ANTONIO CHARLYS; LEAL, ELCIO. Detection of RNA-Dependent RNA Polymerase of Hubei Reo-Like Virus 7 by Next-Generation Sequencing in Aedes aegypti and Culex quinquefasciatus Mosquitoes from Brazil. Viruses-Basel, v. 11, n. 2 FEB 2019. Web of Science Citations: 0.
LUCHS, ADRIANA; DA COSTA, ANTONIO CHARLYS; CILLI, AUDREY; VASCONCELOS KOMNINAKIS, SHIRLEY CAVALCANTE; COMPAGNOLI CARMONA, RITA DE CASSIA; BOEN, LAIS; MORILLO, SIMONE GUADAGNUCCI; SABINO, ESTER CERDEIRA; SAMPAIO TAVARES TIMENETSKY, MARIA DO CARMO. Spread of the emerging equine-like G3P[8] DS-1-like genetic backbone rotavirus strain in Brazil and identification of potential genetic variants. JOURNAL OF GENERAL VIROLOGY, v. 100, n. 1, p. 7-25, JAN 2019. Web of Science Citations: 5.
RIBEIRO, GEOVANI DE OLIVEIRA; LUCHS, ADRIANA; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; GILL, DANIELLE ELISE; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; BRUSTULIN, RAFAEL; DAS CHAGAS, ROGERIO TOGISAKI; NEVES DOS SANTOS ABRAO, MARIA DE FATIMA; DE DEUS ALVES SOARES, CASSIA VITORIA; WITKIN, STEVEN S.; VILLANOVA, FABIOLA; DENG, XUTAO; SABINO, ESTER CERDEIRA; DELWART, ERIC; DA COSTA, ANTONIO CHARLYS; LEAL, ELCIO. Detection and Characterization of Enterovirus B73 from a Child in Brazil. Viruses-Basel, v. 11, n. 1 JAN 2019. Web of Science Citations: 0.
AUDREY CILLI; ADRIANA LUCHS; ELCIO LEAL; DANIELLE GILL; FLAVIO AUGUSTO DE PÁDUA MILAGRES; SHIRLEY VASCONCELOS KOMNINAKIS; RAFAEL BRUSTULIN; MARIA DA APARECIDA RODRIGUES TELES; MÁRCIA CRISTINA ALVES BRITO SAYÃO LOBATO; ROGÉRIO TOGISAKI DAS CHAGAS; MARIA DE FÁTIMA NEVES DOS SANTOS ABRÃO; CASSIA VITÓRIA DE DEUS ALVES SOARES; XUTAO DENG; ERIC DELWART; ESTER CERDEIRA SABINO; ANTONIO CHARLYS DA COSTA. Human sapovirus GI.2 and GI.3 from children with acute gastroenteritis in northern Brazil. Memórias do Instituto Oswaldo Cruz, v. 114, p. -, 2019.
LUCHS, ADRIANA; LEAL, ELCIO; TARDY, KAELAN; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; BRUSTULIN, RAFAEL; RODRIGUES TELES, MARIA DA APARECIDA; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; DAS CHAGAS, ROGERIO TOGISAKI; NEVES DOS SANTOS ABRAO, MARIA DE FATIMA; DE DEUS ALVES SOARES, CASSIA VITORIA; DENG, XUTAO; DELWART, ERIC; SABINO, ESTER CERDEIRA; DA COSTA, ANTONIO CHARLYS. The rare enterovirus c99 and echovirus 29 strains in Brazil: potential risks associated to silent circulation. Memórias do Instituto Oswaldo Cruz, v. 114, 2019. Web of Science Citations: 0.
FERNANDES, LICIA NATAL; COLETTI, THAIS DE MOURA; COSTA MONTEIRO, FRED JULIO; DA SILVA REGO, MARLISSON OCTAVIO; D'ATHAIDE RIBEIRO, EDCELHA SOARES; RIBEIRO, GEOVANI DE OLIVEIRA; SOUZA MARINHO, ROBSON DOS SANTOS; KOMNINAKIS, SHIRLEY VASCONCELOS; WITKIN, STEVEN S.; DENG, XUTAO; DELWART, ERIC; SABINO, ESTER CERDEIRA; LEAL, ELCIO; DA COSTA, ANTONIO CHARLYS. A Novel Highly Divergent Strain of Cell Fusing Agent Virus (CFAV) in Mosquitoes from the Brazilian Amazon Region. Viruses-Basel, v. 10, n. 12 DEC 2018. Web of Science Citations: 1.
DA COSTA, ANTONIO CHARLYS; LUCHS, ADRIANA; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; GILL, DANIELLE ELISE; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; BRUSTULIN, RAFAEL; DAS CHAGAS, ROGERIO TOGISAKI; NEVES DOS SANTOS ABRAO, MARIA DE FATIMA; DE DEUS ALVES SOARES, CASSIA VITORIA; DENG, XUTAO; SABINO, ESTER CERDEIRA; DELWART, ERIC; LEAL, ELCIO. Recombination Located over 2A-2B Junction Ribosome Frameshifting Region of Saffold Cardiovirus. Viruses-Basel, v. 10, n. 10 OCT 2018. Web of Science Citations: 2.
FARIA, N. R.; KRAEMER, M. U. G.; HILL, S. C.; DE JESUS, J. GOES; AGUIAR, R. S.; IANI, F. C. M.; XAVIER, J.; QUICK, J.; DU PLESSIS, L.; DELLICOUR, S.; THEZE, J.; CARVALHO, R. D. O.; BAELE, G.; WU, C. -H.; SILVEIRA, P. P.; ARRUDA, M. B.; PEREIRA, M. A.; PEREIRA, G. C.; LOURENCO, J.; OBOLSKI, U.; ABADE, L.; VASYLYEVA, T. I.; GIOVANETTI, M.; YI, D.; WEISS, D. J.; WINT, G. R. W.; SHEARER, F. M.; FUNK, S.; NIKOLAY, B.; FONSECA, V.; ADELINO, T. E. R.; OLIVEIRA, M. A. A.; SILVA, M. V. F.; SACCHETTO, L.; FIGUEIREDO, P. O.; REZENDE, I. M.; MELLO, E. M.; SAID, R. F. C.; SANTOS, D. A.; FERRAZ, M. L.; BRITO, M. G.; SANTANA, L. F.; MENEZES, M. T.; BRINDEIRO, R. M.; TANURI, A.; DOS SANTOS, F. C. P.; CUNHA, M. S.; NOGUEIRA, J. S.; ROCCO, I. M.; DA COSTA, A. C.; KOMNINAKIS, S. C. V.; AZEVEDO, V.; CHIEPPE, A. O.; ARAUJO, E. S. M.; MENDONCA, M. C. L.; DOS SANTOS, C. C.; DOS SANTOS, C. D.; MARES-GUIA, A. M.; NOGUEIRA, R. M. R.; SEQUEIRA, P. C.; ABREU, R. G.; GARCIA, M. H. O.; ABREU, A. L.; OKUMOTO, O.; KROON, E. G.; DE ALBUQUERQUE, C. F. C.; LEWANDOWSKI, K.; PULLAN, S. T.; CARROLL, M.; DE OLIVEIRA, T.; SABINO, E. C.; SOUZA, R. P.; SUCHARD, M. A.; LEMEY, P.; TRINDADE, G. S.; DRUMOND, B. P.; FILIPPIS, A. M. B.; LOMAN, N. J.; CAUCHEMEZ, S.; ALCANTARA, L. C. J.; PYBUS, O. G. Genomic and epidemiological monitoring of yellow fever virus transmission potential. Science, v. 361, n. 6405, p. 894+, AUG 31 2018. Web of Science Citations: 42.
DA COSTA, ANTONIO CHARLYS; LUCHS, ADRIANA; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; GILL, DANIELLE ELISE; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; BRUSTULIN, RAFAEL; DAS CHAGAS, ROGERIO TOGISAKI; NEVES DOS SANTOS ABRAO, MARIA DE FATIMA; DE DEUS ALVES SOARES, CASSIA VITORIA; DENG, XUTAO; SABINO, ESTER CERDEIRA; DELWART, ERIC; LEAL, ELCIO. Near full length genome of a recombinant (E/D) cosavirus strain from a rural area in the central region of Brazil. SCIENTIFIC REPORTS, v. 8, AUG 17 2018. Web of Science Citations: 4.
LUCHS, ADRIANA; LEAL, ELCIO; KOMNINAKIS, SHIRLEY VASCONCELOS; DE PADUA MILAGRES, FLAVIO AUGUSTO; BRUSTULIN, RAFAEL; RODRIGUES TELES, MARIA DA APARECIDA; GILL, DANIELLE ELISE; DENG, XUTAO; DELWART, ERIC; SABINO, ESTER CERDEIRA; DA COSTA, ANTONIO CHARLYS. Wuhan large pig roundworm virus identified in human feces in Brazil. VIRUS GENES, v. 54, n. 3, p. 470-473, JUN 2018. Web of Science Citations: 2.
ARANHA WATANABE, ARIPUANA SAKURADA; LUCHS, ADRIANA; LEAL, ELCIO; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; GILL, DANIELLE ELISE; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; BRUSTULIN, RAFAEL; DAS CHAGAS, ROGERIO TOGISAKI; NEVES DOS SANTOS ABRAO, MARIA DE FATIMA; DE DEUS ALVES SOARES, CASSIA VITORIA; DENG, XUTAO; SABINO, ESTER CERDEIRA; DELWART, ERIC; DA COSTA, ANTONIO CHARLYS. Complete Genome Sequences of Six Human Bocavirus Strains from Patients with Acute Gastroenteritis in the North Region of Brazil. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 6, n. 17 APR 2018. Web of Science Citations: 1.
FARIA, NUNO R.; DA COSTA, ANTONIO CHARLYS; LOURENCO, JOSE; LOUREIRO, PAULA; LOPES, MARIA ESTHER; RIBEIRO, ROBERTO; ALENCAR, CECILIA SALETE; KRAEMER, MORITZ U. G.; VILLABONA-ARENAS, CHRISTIAN J.; WU, CHIEH-HSI; THEZE, JULIEN; KHAN, KAMRAN; BRENT, SHANNON E.; ROMANO, CAMILA; DELWART, ERIC; CUSTER, BRIAN; BUSCH, MICHAEL P.; PYBUS, OLIVER G.; SABINO, ESTER C.; EPIDEMIOLOGY, NHLBI RECIPIENT; STUDY, DONOR EVALUATION. Genomic and epidemiological characterisation of a dengue virus outbreak among blood donors in Brazil. SCIENTIFIC REPORTS, v. 7, NOV 9 2017. Web of Science Citations: 12.

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