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Modulation of systemic inflammatory response in preeclampsia

Abstract

The literature has been suggesting that the exacerbated systemic inflammatory response detected in pregnant women with preeclampsia (PE) is harmful to the pregnancy progress and may have its origin in placenta. Both innate and adaptive immunity may be involved in this process. Systemic inflammation is a key feature in PE and is represented by excessive concentrations of pro-inflammatory cytokines, associated with reduction of regulatory cytokines and abnormally activated phenotype of cells of innate and adaptive immunity. Thus, both in the systemic circulation and in placenta occur an imbalance between pro-and anti-inflammatory cytokines, activation of NLRP1 and NLRP3 inflammasomes and a polarization of monocytes and T lymphocytes subpopulations to an inflammatory profile, probably dependent on regulatory factors deficiency capable of modulating this inflammatory response. This imbalance could be reduced by the treatment with substances derived from natural products with anti-inflammatory activity, vitamin D and hormones such as progesterone. The present project consisting of four sub-projects has been developed with the objective of evaluating the mechanisms involved in placental and systemic inflammatory responses detected in pregnant women with PE, and to investigate the immunomodulatory effect of hormones such as progesterone, natural products with anti-inflammatory activity such as silybin and vitamin D on monocytes, T cell subsets and placental tissue obtained from preeclamptic women. Thus, the vitro treatment of placental explants and T lymphocytes with vitamin D, and the study of cell signaling pathways in monocytes will allow better understanding of the processes involved in systemic inflammation of PE, and possibly propose alternative ways to treat this important pregnancy syndrome. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MATIAS, MARIANA LETICIA; ROMAO-VEIGA, MARIANA; RIBEIRO, VANESSA ROCHA; NUNES, PRISCILA REZECK; GOMES, VIRGINIA JULIANI; DEVIDES, AMANDA CARREIRA; BORGES, VERA THEREZINHA; ROMAGNOLI, GRAZIELA GORETTI; PERACOLI, JOSE CARLOS; PERACOLI, MARIA TEREZINHA. Progesterone and vitamin D downregulate the activation of the NLRP1/ NLRP3 inflammasomes and TLR4-MyD88-NF-kappa B pathway in monocytes from pregnant women with preeclampsia. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, v. 144, APR 2021. Web of Science Citations: 0.
GOMES, VIRGINIA JULIANI; NUNES, PRISCILA REZECK; MATIAS, MARIANA LETICIA; RIBEIRO, VANESSA ROCHA; DEVIDES, AMANDA CARREIRA; BANNWART-CASTRO, CAMILA FERREIRA; ROMAGNOLI, GRAZIELA GORETE; PERACOLI, JOSE CARLOS; SERRAO PERACOLI, MARIA TEREZINHA; ROMAO-VEIGA, MARIANA. Silibinin induces in vitro M2-like phenotype polarization in monocytes from preeclamptic women. International Immunopharmacology, v. 89, n. A DEC 2020. Web of Science Citations: 0.
MATIAS, MARIANA LETICIA; GOMES, VIRGINIA JULIANI; ROMAO-VEIGA, MARIANA; RIBEIRO, VANESSA ROCHA; NUNES, PRISCILA REZECK; ROMAGNOLI, GRAZIELA GORETE; PERACOLI, JOSE CARLOS; SERRAO PERACOLI, MARIA TEREZINHA. Silibinin Downregulates the NF-B Pathway and NLRP1/NLRP3 Inflammasomes in Monocytes from Pregnant Women with Preeclampsia. Molecules, v. 24, n. 8 APR 2 2019. Web of Science Citations: 3.

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