Lipidomic analysis of cancer patients blood in the search for possible circulatory biomarkers

• Grant number: 16/11905-2
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2017
• End date: June 30, 2019
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Patrícia de Oliveira Carvalho
• Grantee: Patrícia de Oliveira Carvalho
• Host Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil

Abstract

During the development of carcinogenic cells, reprogramming of their metabolic pathways and other alterations occur due to cell growth and proliferation, energy sources, inflammation, tumor-related enzymatic metabolism and others. Such alterations are intimately related to lipid metabolism so that lipids become an excellent source of information on cell metabolism in tumorigenesis. Possible biomarkers of the response to those alterations can be obtained by means of a lipidomic strategy based on analytic tools that identify and quantify plasmatic and cellular lipids precisely, and on a large scale. This project proposes a broad and systematic (qualitative and quantitative) assessment of lipids in blood samples (plasma and erythrocytes) drawn from healthy volunteers and from patients with (colorectal and mammary) cancer undergoing treatment at the São Francisco na Providência de Deus University Hospital (Bragança Paulista, São Paulo). Two other research centers participate in the project. Chromatographic and high resolution mass spectrometry analyses will be used with an analytical platform capable of analyzing around 3,000 lipids. The differentiated molecules will be indicated by means of multivariate statistics tools. The lipidomic approach will be of fundamental importance in the discovery of biomarkers and in enabling an understanding of the molecular basis of specific pathologies. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MECATTI, GIOVANA COLOZZA; MESSIAS, MARCIA CRISTINA FERNANDES; CARVALHO, PATRICIA DE OLIVEIRA. Lipidomic profile and candidate biomarkers in septic patients. LIPIDS IN HEALTH AND DISEASE, v. 19, n. 1, APR 13 2020. (16/11905-2)

FERNANDES MESSIAS, MARCIA CRISTINA; MECATTI, GIOVANA COLOZZA; FIGUEIREDO ANGOLINI, CELIO FERNANDO; EBERLIN, MARCOS NOGUEIRA; CREDIDIO, LAURA; REAL MARTINEZ, CARLOS AUGUSTO; RODRIGUES COY, CLAUDIO SADDY; CARVALHO, PATRICIA DE OLIVEIRA. Plasma lipidomic signature of rectal adenocarcinoma reveals Potential Biomarkers. FRONTIERS IN ONCOLOGY, v. 7, JAN 8 2018. (16/11905-2)

FERNANDES MESSIAS, MARCIA CRISTINA; MECATTI, GIOVANA COLOZZA; PRIOLLI, DENISE GONCALVES; CARVALHO, PATRICIA DE OLIVEIRA. Plasmalogen lipids: functional mechanism and their involvement in gastrointestinal cancer. LIPIDS IN HEALTH AND DISEASE, v. 17, MAR 7 2018. (16/11905-2)

WOOD, PAUL L.; DONOHUE, MICHELLE M.; CEBAK, JOHN E.; BECKMANN, TAYLOR G.; FERNANDES MESSIAS, MARCIA CRISTINA; CREDIDIO, LAURA; RODRIGUES COY, CLAUDIO SADDY; CARVALHO, PATRICIA DE OLIVEIRA; CROTTI, SARA; D'ARONCO, SARA; et al. Reduced Plasma Levels of Very-Long-Chain Dicarboxylic Acid 28:4 in Italian and Brazilian Colorectal Cancer Patient Cohorts. METABOLITES, v. 8, n. 4, DEC 2018. (16/11905-2)