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Evaluation of immunoregulatory microenvironment of oral premalignant lesions, squamous cell carcinomas and oropharyngeal carcinomas related to HPV or not

Grant number: 15/07727-9
Support type:Regular Research Grants
Duration: March 01, 2017 - February 28, 2019
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Paulo Henrique Braz da Silva
Grantee:Paulo Henrique Braz da Silva
Home Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers: Bengt Olof Valter Hasséus ; Juliana Lucena Schussel ; Suzana Cantanhede Orsini Machado de Sousa

Abstract

The study of tumor microenvironment is extremely important for understanding the individual immune response to neoplastic cells. Immunotolerance is a physiological mechanism by which the immune system self-regulate, by inhibiting the effector cell response, making it difficult for immune response initiation. This mechanism inhibits the development of autoimmune diseases, controlling and modulating chronic inflammation. Immature dendritic cells, regulatory T cells and numerous immunosuppressive cytokines and chemokines such as IL-10 and MIP3 alpha play a central role in this context. However, it is known that some tumors, especially those which have a viral etiological factor involved are capable of inducing an immunotolerant environment, thus inhibiting the immune response effectively preventing the recognition and destruction of neoplastic cells. Some studies have reported the existence of tolerant microenvironment in neoplastic lesions of the cervix associated with HPV. Given the above, the aim is to analyze the microenvironment of potentially malignant lesions and oropharyngeal carcinomas related to HPV or not, for the presence of immature dendritic cells, FOXP3 + regulatory T cells and expression of MIP3 alpha. (AU)

Scientific publications (13)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SUNDBERG, JONAS; OHMAN, JENNY; KORYTOWSKA, MAGDALENA; WALLSTROM, MATS; KJELLER, GORAN; ANDERSSON, MARIA; HORAL, PETER; LINDH, MAGNUS; GIGLIO, DANIEL; KOVACS, ANIKO; SAND, LARS; HIRSCH, JAN-MICHAEL; ARAUJO FERRACINI, LAIS MAGDA; MAMANA FERNANDES DE SOUZA, ANA CAROLINA; PARLATESCU, IOANINA; DOBRE, MARIA; HINESCU, MIHAIL-EUGEN; BRAZ-SILVA, PAULO HENRIQUE; TOVARU, SERBAN; HASSEUS, BENGT. High-risk human papillomavirus in patients with oral leukoplakia and oral squamous cell carcinoma-A multi-centre study in Sweden, Brazil and Romania. ORAL DISEASES, JUL 2020. Web of Science Citations: 0.
DE SANTANA SARMENTO, DMITRY JOSE; TOZETTO-MENDOZA, TANIA REGINA; FERNANDES DE SOUZA, ANA CAROLINA MAMANA; MACIEL, RAFAEL; PAIAO, HEUDER; LIMA, SILVIA HELENA; CRISTELLI, MARINA; MEDINA DE ABREU PESTANA, JOSE OSMAR; BRAZ-SILVA, PAULO HENRIQUE; GALLOTTINI, MARINA. Herpesviruses oral shedding and viremia in renal transplant recipients: A longitudinal study. TRANSPLANT INFECTIOUS DISEASE, v. 22, n. 4 JUN 2020. Web of Science Citations: 0.
MIRANDA-SILVA, WANESSA; KNEBEL, FRANCIELE HINTERHOLZ; TOZETTO-MENDOZO, TANIA REGINA; PALMIERI, MICHELLE; DA FONSECA, FELIPE PAIVA; CAMARGO, ANAMARIA ARANHA; BRAZ-SILVA, PAULO HENRIQUE; FREGNANI, EDUARDO RODRIGUES. Herpesviruses in the oral cavity of patients subjected to allogeneic hematopoietic stem cell transplantation and its relationship with oral mucositis. CLINICAL ORAL INVESTIGATIONS, FEB 2020. Web of Science Citations: 0.
MARIANA LOBO BERGAMINI; ANDRESSA PINTO MARDEGAN; CATHARINA SIMIONI DE ROSA; MICHELLE PALMIERI; DMITRY JOSÉ DE SANTANA SARMENTO; KAREN RENATA NAKAMURA HIRAKI; ANDRÉ LUIZ FERREIRA COSTA; BENGT HASSÉUS; PETER JONASSON; PAULO HENRIQUE BRAZ-SILVA. Presence of langerhans cells, regulatory T cells (Treg) and mast cells in asymptomatic apical periodontitis. Brazilian Oral Research, v. 34, p. -, 2020.
DE OLIVEIRA, MARCIO AUGUSTO; REIS, BRUNA; PALLOS, DEBORA; KIM, YEON JUNG; BRAZ-SILVA, PAULO HENRIQUE; MARTINS, FABIANA. The Importance of Histopathological Examination to the Final Diagnosis of Peripheral Odontogenic Tumors: A Case Report of a Peripheral Odontoma. CASE REPORTS IN DENTISTRY, v. 2019, SEP 8 2019. Web of Science Citations: 0.
BRAZ-SILVA, PAULO HENRIQUE; BERGAMINI, MARIANA LOBO; MARDEGAN, ANDRESSA PINTO; DE ROSA, CATHARINA SIMIONI; HASSEUS, BENGT; JONASSON, PETER. Inflammatory profile of chronic apical periodontitis: a literature review. ACTA ODONTOLOGICA SCANDINAVICA, v. 77, n. 3, p. 173-180, APR 3 2019. Web of Science Citations: 3.
DO CANTO, ALAN MOTTA; REIS DA SILVA MARCELINO, BARBARA MICHAELA; SCHUSSEL, JULIANA LUCENA; WASTNER, BRUNA F.; SASSI, LAURINDO MOACIR; CORREA, LUCIANA; DE FREITAS, RONALDO RODRIGUES; HASSEUS, BENGT; KJELLER, GORAN; LEMOS JUNIOR, CELSO AUGUSTO; BRAZ-SILVA, PAULO HENRIQUE. Immunohistochemical analysis of BRAF V600E mutation in ameloblastomas. CLINICAL ORAL INVESTIGATIONS, v. 23, n. 2, p. 779-784, FEB 2019. Web of Science Citations: 2.
DANIELA ASSIS DO VALE; LAIS MAGDA ARAÚJO FERRACINI; MARCUS VINÍCIUS DA SILVA RODRIGUES BUENO; ANA CAROLINA MAMANA FERNANDES SOUZA; PAULO HENRIQUE BRAZ-SILVA; KAREM LÓPEZ ORTEGA. Unusual presentation of a disseminated oral HPV infection after combined antiretroviral therapy initiation. Revista do Instituto de Medicina Tropical de São Paulo, v. 61, p. -, 2019. Web of Science Citations: 0.
DE SANTANA SARMENTO, DMITRY JOSE; PALMIERI, MICHELLE; GALVAO, GUSTAVO SOUZA; TOZETTO-MENDOZA, TANIA REGINA; DO CANTO, CYNTHIA MOTTA; PIERROTTI, LIGIA CAMERA; DAVID-NETO, ELIAS; AGENA, FABIANA; GALLOTTINI, MARINA; PANNUTI, CLAUDIO SERGIO; DOMINGUES FINK, MARIA CRISTINA; BRAZ-SILVA, PAULO HENRIQUE. BK virus salivary shedding and viremia in renal transplant recipients. Journal of Applied Oral Science, v. 27, 2019. Web of Science Citations: 0.
MEDINA, J. B.; ANDRADE, N. S.; DE PAULA EDUARDO, F.; BEZINELLI, L.; FRANCO, J. B.; GALLOTTINI, M.; BRAZ-SILVA, P. H.; ORTEGA, K. L. Bleeding during and after dental extractions in patients with liver cirrhosis. International Journal of Oral and Maxillofacial Surgery, v. 47, n. 12, p. 1543-1549, DEC 2018. Web of Science Citations: 2.
GANESH, DIVYA; SREENIVASAN, PRATHIMA; OHMAN, JENNY; WALLSTROM, MATS; BRAZ-SILVA, PAULO HENRIQUE; GIGLIO, DANIEL; KJELLER, GORAN; HASSEUS, BENGT. Potentially Malignant Oral Disorders and Cancer Transformation. ANTICANCER RESEARCH, v. 38, n. 6, p. 3223-3229, JUN 2018. Web of Science Citations: 5.
PALMIERI, MICHELLE; ORNAGHI, MARIANA; DE OLIVEIRA MARTINS, VICTOR ADRIANO; CORREA, LUCIANA; BRANDAO, THAIS BIANCA; DO PRADO RIBEIRO, ANA CAROLINA; SUMITA, LAURA MASAMI; TOZETTO-MENDOZA, TANIA REGINA; PANNUTI, CLAUDIO SERGIO; BRAZ-SILVA, PAULO HENRIQUE. Oral shedding at human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia. JOURNAL OF ORAL MICROBIOLOGY, v. 10, MAY 28 2018. Web of Science Citations: 1.
BRAZ-SILVA, PAULO HENRIQUE; DO CANTO, ALAN MOTTA; OLIVEIRA, LETICIA; MARTINS, FABIANA; PEREIRA DA COSTA, ALESSANDRO ANTONIO; COSTA HANEMANN, JOAO ADOLFO. Sclerosing Polycystic Adenosis of Tongue. BULLETIN OF TOKYO DENTAL COLLEGE, v. 59, n. 2, p. 121-125, 2018. Web of Science Citations: 1.

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