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Nutritional suplementation and exercise to optimize exercise performance: focus on individual responses and a step towards personalized sports nutrition

Grant number: 16/50438-0
Support type:Research Grants - Young Investigators Grants
Duration: April 01, 2017 - March 31, 2021
Field of knowledge:Health Sciences - Physical Education
Cooperation agreement: Newton Fund, with FAPESP as a partner institution in Brazil
Principal Investigator:Bryan Saunders
Grantee:Bryan Saunders
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated grant(s):18/13124-3 - Placebo effects: from health to sport, AV.EXT
Associated scholarship(s):18/01594-5 - Blood and muscle responses to sodium bicarbonate supplementation and subsequent exercise performance, BP.MS
17/15314-1 - The influence of the CYP1A2 polymorphism on the physiological responses and performance following acute supplementation with caffeine, BP.MS
17/24841-5 - Sodium bicarbonate supplementation on 1-km cycling time-trial performance, BP.IC
17/04973-4 - Nutritional supplementation and exercise to optimise exercise performance: focus on individual responses and a step towards personalized sports nutrition, BP.JP

Abstract

Ergogenic aids are nutritional supplements predominantly directed towards enhancing exercise capacity and performance, although they may else provide health related benefits. Sodium bicarbonate, caffeine and β-alanine have become essential training additions for elite, professional and recreational athletes alike and their efficacy in improving exercise capacity and performance is supported by substantial research. Nonetheless, variability in responses has led to recent suggestion that supplementation may not be beneficial to all individuals. lt is of interest to determine the sources of inter- and intra-individual variations and whether resulting information can be used to optimize dosing strategies for exercise performance. Study 1 will evaluate the consistency in responses to sodium bicarbonate supplementation, revealing whether we can viably individualise the timing of ingestion according to the individual. In study 2 we will determine whether enteric capsules can optimize the dose response to sodium bicarbonate supplementation, and alleviate some of the associated side-effects. Study 3 will elucidate the consistency in exercise responses to supplementation with sodium bicarbonate, while study 4 will determine whether changes in muscle transporter activity are related to the changes in circulating bicarbonate. Study 5 will determine the time course blood responses following caffeine ingestion between individuals with different phenotypes for caffeine metabolism, while study 6 will determine the role of phenotype upon the efficacy of caffeine for exercise. Study 7 will determine the acute metabolic responses to β-alanine supplementation pre and post 4 weeks of supplementation, while study 8 will determine whether an acute bout of training also influences these same metabolic responses. We believe that the results obtained in this comprehensive project will have significant and long-lasting impacts on the understanding of acute metabolic responses to supplementation and exercise, and will play a fundamental part in the optimization of supplementation for athletic populations, as well as directing future work in the area. (AU)

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOLAN, EIMEAR; SWINTON, PAUL A.; PAINELLI, VITOR DE SALLES; HEMINGWAY, BENEDICT STEPHENS; MAZZOLANI, BRUNA; SMAIRA, FABIANA INFANTE; SAUNDERS, BRYAN; ARTIOLI, GUILHERME G.; GUALANO, BRUNO. A Systematic Risk Assessment and Meta-Analysis on the Use of Oral beta-Alanine Supplementation. ADVANCES IN NUTRITION, v. 10, n. 3, p. 452-463, MAY 2019. Web of Science Citations: 0.
BASSINELLO, DIOGO; PAINELLI, VITOR DE SALLES; DOLAN, EIMEAR; LIXANDRAO, MANOEL; CAJUEIRO, MONIQUE; DE CAPITANI, MARIANA; SAUNDERS, BRYAN; SALE, CRAIG; ARTIOLI, GUILHERME G.; GUALANO, BRUNO; ROSCHEL, HAMILTON. Beta-alanine supplementation improves isometric, but not isotonic or isokinetic strength endurance in recreationally strength-trained young men. Amino Acids, v. 51, n. 1, p. 27-37, JAN 2019. Web of Science Citations: 0.
DA SILVA, RAFAEL PIRES; DE OLIVEIRA, LUANA FARIAS; SAUNDERS, BRYAN; KRATZ, CAROLINE DE ANDRADE; PAINELLI, VITOR DE SALLES; SILVA, VINICIUS DA EIRA; BOUZAS MARINS, JOAO CARLOS; FRANCHINI, EMERSON; GUALANO, BRUNO; ARTIOLI, GUILHERME GIANNINI. Effects of -alanine and sodium bicarbonate supplementation on the estimated energy system contribution during high-intensity intermittent exercise. Amino Acids, v. 51, n. 1, p. 83-96, JAN 2019. Web of Science Citations: 0.
DE OLIVEIRA, LUANA FARIAS; SAUNDERS, BRYAN; ARTIOLI, GUILHERME GIANNINI. Is Bypassing the Stomach a Means to Optimize Sodium Bicarbonate Supplementation? A Case Study With a Postbariatric Surgery Individual. INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, v. 28, n. 6, p. 660-663, NOV 2018. Web of Science Citations: 0.
PAINELLI, VITOR DE SALLES; NEMEZIO, KLEINER MARCIO; PINTO, ANA JESSICA; FRANCHI, MARIANA; ANDRADE, ISABEL; RIANI, LUIZ AUGUSTO; SAUNDERS, BRYAN; SALE, CRAIG; HARRIS, ROGER CHARLES; GUALANO, BRUNO; ARTIOLI, GUILHERME GIANNINI. High-Intensity Interval Training Augments Muscle Carnosine in the Absence of Dietary Beta-alanine Intake. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 50, n. 11, p. 2242-2252, NOV 2018. Web of Science Citations: 1.
DOLAN, E.; SAUNDERS, B.; DANTAS, W. S.; MURAI, I. H.; ROSCHEL, H.; ARTIOLI, G. G.; HARRIS, R.; BICUDO, J. E. P. W.; SALE, C.; GUALANO, B. A Comparative Study of Hummingbirds and Chickens Provides Mechanistic Insight on the Histidine Containing Dipeptide Role in Skeletal Muscle Metabolism. SCIENTIFIC REPORTS, v. 8, OCT 3 2018. Web of Science Citations: 0.
SWINTON, PAUL A.; HEMINGWAY, BEN STEPHENS; SAUNDERS, BRYAN; GUALANO, BRUNO; DOLAN, EIMEAR. A Statistical Framework to Interpret Individual Response to Intervention : Paving the Way for Personalized Nutrition and Exercise Prescription. FRONTIERS IN NUTRITION, v. 5, MAY 28 2018. Web of Science Citations: 5.
HEIBEL, ANDRE B.; PERIM, PEDRO H. L.; OLIVEIRA, LUANA F.; MCNAUGHTON, LARS R.; SAUNDERS, BRYAN. Time to Optimize Supplementation: Modifying Factors Influencing the Individual Responses to Extracellular Buffering Agents. FRONTIERS IN NUTRITION, v. 5, MAY 8 2018. Web of Science Citations: 2.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.