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Gonçalo Bernardes | University of Cambridge - Inglaterra

Grant number: 16/50427-9
Support type:Research Grants - Visiting Researcher Grant - International
Duration: May 01, 2019 - May 31, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Cooperation agreement: Newton Fund, with FAPESP as a partner institution in Brazil
Principal researcher:Márcio Weber Paixão
Grantee:Márcio Weber Paixão
Visiting researcher: Gonçalo Bernardes
Visiting researcher institution: University of Cambridge, England
Principal researcher abroad: Gonçalo Bernanrdes
Institution abroad: University of Cambridge, England
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil


The long-term objective of this project is to contribute to the development of next generation ADCs as promising cancer therapeutics. We will prepare new conjugates for cancer therapy and imaging using a novel site-specific conjugation reaction for the conjugation of drugs and imaging probes to mAbs primarily in the IgG format (it can be extended to smaller recombinant formats). Ideally, the outcome of the project will be a starting point for pre-clinical evaluation of new ADCs. (AU)

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