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Cell therapy process otimization for wound healing treatment in patients: biodressing development and evaluation of therapeutic potential of keratinocytes, fibroblasts and mesenchymal cells in chronic ulcers and severe burns


The skin is the largest human organ and has important functions like protection, thermal regulation and prevention of body dehydration. Thus, the loss of skin integrity could be responsible for several complications. Currently, the increase in life expectancy in humans has been associated with an increase in the incidence of chronic wounds, commonly associated with venous and arterial insufficiency and neuropathies; it may also be associated with diabetes. Chronic and severe wounds such as those caused by extensive burns are challenging specialists to deal with, leading to long treatment time and high costs for health systems. Burns are the five most commons accidents in Brazil, in national health system are treated 2300 burns of month. Therapeutic alternatives are already available for the treatment of extensive burn wounds and chronic wounds, however, there is a therapeutic hiatus represented by patients in which these conventional therapies are not effective. In this sense, in recent years, cell therapy has demonstrated to be promising. In pre-clinical and clinical studies, therapy using autologous skin cells such as keratynocites and fibroblasts or mesenchymal cells have already shown good results by speeding the wound and burns treatment. Therefore, the objective of the present project is the optimization of cell therapy process, development of biodressing with cells and to assess the therapeutic potential of the the co-administration of queratinocytes and fibroblasts or mesenchymal cells in patients with chronic wounds from distinct etiologies and burns. The results of this research project could provide new insights to wound healing therapies in patients with chronic ulcers and burns. (AU)

Articles published in Pesquisa para Inovação FAPESP about research grant:
In Situ Cell Therapy wins eAwards Brazil 2023 
Biodressing made from stem cells permits smart treatment of wounds and burns 
Articles published in Agência FAPESP Newsletter about the research grant:
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