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Biodiversity of marine algae and metabolites of economical impact

Abstract

Marine algae have to develop defense strategies, in order to survive in a competitive environment, that result in a tremendous diversity of compounds from different metabolic pathways. Recent trends in drug research from natural sources have shown that algae are promising organisms to furnish novel biochemically active compounds. The aim of this project is to study the compounds biosynthesized by algae with potential economic impact in food science, public health, pharmaceutical, cosmetic and agriculture industries. Emphasis is given to antioxidants, fatty acids (specially omega 3 and 6 families), aminoacids, carotenoids, steroids, polysaccharides, and UV absorber molecules (mycosporine-like amino acids, MAA). Macroalgae will be collected at marine coastal of Brazil and in Atartica. Assays will be performed in which includes anticancer, leishmanicide, schistosomacide activities and enzymes such as acetylcolineterase, topoisomerases, superoxide dismutase and catalase. Extracts with potential activities will be purifies and the chemical structure elucidated. (AU)

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CLEMENTINO, LEANDRO DA COSTA; SANTOS FERNANDES, GUILHERME FELIPE; PROKOPCZYK, IGOR MUCCILO; LAURINDO, WILQUER CASTRO; TOYAMA, DANYELLE; MOTTA, BRUNO PEREIRA; BAVIERA, AMANDA MARTINS; HENRIQUE-SILVA, FLAVIO; DOS SANTOS, JEAN LEANDRO; GRAMINHA, MARCIA A. S.. esign, synthesis and biological evaluation of N-oxide derivatives with potent in vivo antileishmanial activit. PLoS One, v. 16, n. 11, . (16/06931-4, 17/03552-5)
STEIN, ERIKA M.; TAJU, SARA G.; MIYASATO, PATRICIA A.; DE FREITAS, RAFAELA P.; TALLARICO, LENITA DE F.; DOS SANTOS, GUILHERME S.; LUIZ, GIOVANA L. F.; ROFATTO, HENRIQUE K.; DA SILVA, FABIO N. V.; COLEPICOLO, PIO; et al. The Prospective Use of Brazilian Marine Macroalgae in Schistosomiasis Control. MARINE DRUGS, v. 19, n. 5, . (16/06931-4, 17/07346-0, 16/16223-7)
NAKAMURA-GOUVEA, NATALIA; ALVES-LIMA, CICERO; BENITES, LUIZ FELIPE; IHA, CINTIA; MARACAJA-COUTINHO, VINICIUS; ALIAGA-TOBAR, VICTOR; CARNEIRO, MARCELLA; YOKOYA, NAIR S.; MARINHO-SORIANO, ELIANE; GRAMINHA, MARCIA A. S.; et al. Insights into agar and secondary metabolite pathways from the genome of the red alga Gracilaria domingensis (Rhodophyta, Gracilariales). JOURNAL OF PHYCOLOGY, v. 58, n. 3, p. 18-pg., . (18/26220-0, 16/06931-4, 19/06983-2)
GUILHERME, JULIANA ROCHA; PACHECO, BRUNA; SOARES, BRUNO MEIRA; PEREIRA DE PEREIRA, CLAUDIO MARTIN; COLEPICOLO, PIO; DIAS, DAIANE. Phaeophyceae and rhodophyceae macroalgae from the Antarctic: A source of selenium. Journal of Food Composition and Analysis, v. 88, . (16/06931-4)
SPAGOLLA NAPOLEAO TAVARES, RENATA; STUCHI MARIA-ENGLER, SILVYA; COLEPICOLO, PIO; DEBONSI, HOSANA MARIA; SCHAEFER-KORTING, MONIKA; MARX, UWE; RIGO GASPAR, LORENA; ZOSCHKE, CHRISTIAN. Skin Irritation Testing beyond Tissue Viability: Fucoxanthin Effects on Inflammation, Homeostasis, and Metabolism. PHARMACEUTICS, v. 12, n. 2, . (14/50928-2, 16/06931-4)
DOS SANTOS, GUILHERME SENNA; MIYASATO, PATRICIA AOKI; STEIN, ERIKA MATTOS; COLEPICOLO, PIO; WRIGHT, ANTHONY D.; DE BRAGANCA PEREIRA, CARLOS ALBERTO; FALKENBERG, MIRIAM; NAKANO, ELIANA. Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control. MARINE DRUGS, v. 20, n. 2, p. 10-pg., . (17/07346-0, 16/06931-4, 16/16223-7)
RANGEL, KAREN CRISTINA; VILLELA, LEONARDO ZAMBOTTI; PEREIRA, KARINA DE CASTRO; COLEPICOLO, PIO; DEBONSI, HOSANA MARIA; GASPAR, LORENA RIGO. Assessment of the photoprotective potential and toxicity of Antarctic red macroalgae extracts from Curdiea racovitzae and Iridaea cordata for cosmetic use. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, v. 50, . (14/50926-0, 16/06931-4)
RANGEL, KAREN C.; DEBONSI, HOSANA M.; CLEMENTINO, LEANDRO C.; GRAMINHA, MARCIA A. S.; VILELA, LEONARDO Z.; COLEPICOLO, PIO; GASPAR, LORENA R.. Antileishmanial activity of the Antarctic red algae Iridaea cordata (Gigartinaceae; Rhodophyta). JOURNAL OF APPLIED PHYCOLOGY, v. 31, n. 2, p. 825-834, . (17/03552-5, 16/06931-4)
ALVES-LIMA, CICERO; AZEVEDO TEIXEIRA, ANDRE REIS; HOTTA, CARLOS TAKESHI; COLEPICOLO, PIO. A cheap and sensitive method for imaging Gracilaria (Rhodophyta, Gracilariales) growth. JOURNAL OF APPLIED PHYCOLOGY, v. 31, n. 2, p. 885-892, . (13/05301-9, 15/06260-0, 16/06931-4)
TEIXEIRA, THAIZ RODRIGUES; DOS SANTOS, GUSTAVO SOUZA; ARMSTRONG, LORENE; COLEPICOLO, PIO; DEBONSI, HOSANA MARIA. Antitumor Potential of Seaweed Derived-Endophytic Fungi. ANTIBIOTICS-BASEL, v. 8, n. 4, . (14/50926-0, 16/06931-4)

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Filed patent(s) as a result of this research project

USO DE VIRIDICATINA E VIRIDICATOL NO PREPARO DE FORMULAÇÕES COSMÉTICAS COM ATIVIDADE FOTOPROTETORA E ANTIOXIDANTE E DE FORMULAÇÕES FARMACÊUTICAS PARA PREVENÇÃO E/OU TRATAMENTO DE DOENÇAS INFLAMATÓRIAS E DOENÇAS PARASITÁRIAS BR1020200178997 - Universidade de São Paulo (USP) . LUDMILLA TONANI / ANA PATRÍCIA YATSUDA NATSUI / HOSANA MARIA DEBONSI / CAMILA MARTINS KAWAKAMI / CLENI MARA MARZOCCHI MACHADO / JADE CABESTRE VENANCIO BROCHI / KAREN CRISTINA RANGEL / LEANDRO DA COSTA CLEMENTINO / LORENA RIGO GASPAR CORDEIRO / Luiz Miguel Pereira / MARCIA APARECIDA SILVA GRAMINHA / MARCIA REGINA VON ZESKA KRESS / NATHÁLIA CRISTINA CANICOBA / PÉRICLES GAMA ABREU FILHO / PIO COLEPICOLO NETO / RENATA SPAGOLLA NAPOLEÃO TAVARES / SILVYA STUCHI MARIA ENGLER / THAIZ RODRIGUES TEIXEIRA - September 2020, 01