Biodiversity of marine algae and metabolites of economical impact

• Grant number: 16/06931-4
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
• Duration: April 01, 2017 - March 31, 2024
• Field of knowledge: Physical Sciences and Mathematics - Oceanography - Biological Oceanography
• Principal Investigator: Pio Colepicolo Neto
• Grantee: Pio Colepicolo Neto
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Claudio Martin Pereira de Pereira ; Eliana Nakano ; Eliane Marinhosoriano ; Ernani Pinto Junior ; Hosana Maria Debonsi ; Lorena Rigo Gaspar Cordeiro ; Marcia Aparecida Silva Graminha ; Márcia Foster Mesko ; Mariana Roesch Ely ; Mutue Toyota Fujii ; Nair Sumie Yokoya ; Norberto Peporine Lopes ; Sidnei Moura e Silva ; Yocie Yoneshigue Valentin
• Associated grant(s): 18/05878-8 - Multi-user equipment (EMU) approved in grant 16/06931-4: laboratory scale supercritical extraction unit, AP.EMU
• Associated scholarship(s): 19/06983-2 - Metabolic stress responses in Gracilaria, BP.PD; 18/26220-0 - Genome of Gracilaria domingensis, a macroalgae of economical and environmental importance, BP.TT; 18/10216-4 - Analysis of the biochemical effects of Brazilians red macroalgae species exposed to cadmium, BP.MS; 17/07346-0 - Study of analogues based on marine natural products from species ofgenus Laurencia (Rhodophyta, Ceramiales) for the control of neglected tropical diseases, BP.PD

Abstract

Marine algae have to develop defense strategies, in order to survive in a competitive environment, that result in a tremendous diversity of compounds from different metabolic pathways. Recent trends in drug research from natural sources have shown that algae are promising organisms to furnish novel biochemically active compounds. The aim of this project is to study the compounds biosynthesized by algae with potential economic impact in food science, public health, pharmaceutical, cosmetic and agriculture industries. Emphasis is given to antioxidants, fatty acids (specially omega 3 and 6 families), aminoacids, carotenoids, steroids, polysaccharides, and UV absorber molecules (mycosporine-like amino acids, MAA). Macroalgae will be collected at marine coastal of Brazil and in Atartica. Assays will be performed in which includes anticancer, leishmanicide, schistosomacide activities and enzymes such as acetylcolineterase, topoisomerases, superoxide dismutase and catalase. Extracts with potential activities will be purifies and the chemical structure elucidated. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CLEMENTINO, LEANDRO DA COSTA; SANTOS FERNANDES, GUILHERME FELIPE; PROKOPCZYK, IGOR MUCCILO; LAURINDO, WILQUER CASTRO; TOYAMA, DANYELLE; MOTTA, BRUNO PEREIRA; BAVIERA, AMANDA MARTINS; HENRIQUE-SILVA, FLAVIO; DOS SANTOS, JEAN LEANDRO; GRAMINHA, MARCIA A. S.. esign, synthesis and biological evaluation of N-oxide derivatives with potent in vivo antileishmanial activit. PLoS One, v. 16, n. 11, NOV 1 2021. (16/06931-4, 17/03552-5)

GUILHERME, JULIANA ROCHA; PACHECO, BRUNA; SOARES, BRUNO MEIRA; PEREIRA DE PEREIRA, CLAUDIO MARTIN; COLEPICOLO, PIO; DIAS, DAIANE. Phaeophyceae and rhodophyceae macroalgae from the Antarctic: A source of selenium. Journal of Food Composition and Analysis, v. 88, MAY 2020. (16/06931-4)

RANGEL, KAREN C.; DEBONSI, HOSANA M.; CLEMENTINO, LEANDRO C.; GRAMINHA, MARCIA A. S.; VILELA, LEONARDO Z.; COLEPICOLO, PIO; GASPAR, LORENA R.. Antileishmanial activity of the Antarctic red algae Iridaea cordata (Gigartinaceae; Rhodophyta). JOURNAL OF APPLIED PHYCOLOGY, v. 31, n. 2, p. 825-834, APR 2019. (17/03552-5, 16/06931-4)

ALVES-LIMA, CICERO; AZEVEDO TEIXEIRA, ANDRE REIS; HOTTA, CARLOS TAKESHI; COLEPICOLO, PIO. A cheap and sensitive method for imaging Gracilaria (Rhodophyta, Gracilariales) growth. JOURNAL OF APPLIED PHYCOLOGY, v. 31, n. 2, p. 885-892, APR 2019. (13/05301-9, 15/06260-0, 16/06931-4)

TEIXEIRA, THAIZ RODRIGUES; DOS SANTOS, GUSTAVO SOUZA; ARMSTRONG, LORENE; COLEPICOLO, PIO; DEBONSI, HOSANA MARIA. Antitumor Potential of Seaweed Derived-Endophytic Fungi. ANTIBIOTICS-BASEL, v. 8, n. 4, DEC 2019. (14/50926-0, 16/06931-4)

STEIN, ERIKA M.; TAJU, SARA G.; MIYASATO, PATRICIA A.; DE FREITAS, RAFAELA P.; TALLARICO, LENITA DE F.; DOS SANTOS, GUILHERME S.; LUIZ, GIOVANA L. F.; ROFATTO, HENRIQUE K.; DA SILVA, FABIO N. V.; COLEPICOLO, PIO; et al. The Prospective Use of Brazilian Marine Macroalgae in Schistosomiasis Control. MARINE DRUGS, v. 19, n. 5, MAY 2021. (16/06931-4, 17/07346-0, 16/16223-7)

RANGEL, KAREN CRISTINA; VILLELA, LEONARDO ZAMBOTTI; PEREIRA, KARINA DE CASTRO; COLEPICOLO, PIO; DEBONSI, HOSANA MARIA; GASPAR, LORENA RIGO. Assessment of the photoprotective potential and toxicity of Antarctic red macroalgae extracts from Curdiea racovitzae and Iridaea cordata for cosmetic use. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, v. 50, SEP 2020. (14/50926-0, 16/06931-4)

SPAGOLLA NAPOLEAO TAVARES, RENATA; STUCHI MARIA-ENGLER, SILVYA; COLEPICOLO, PIO; DEBONSI, HOSANA MARIA; SCHAEFER-KORTING, MONIKA; MARX, UWE; RIGO GASPAR, LORENA; ZOSCHKE, CHRISTIAN. Skin Irritation Testing beyond Tissue Viability: Fucoxanthin Effects on Inflammation, Homeostasis, and Metabolism. PHARMACEUTICS, v. 12, n. 2, FEB 2020. (14/50928-2, 16/06931-4)

Filed patent(s) as a result of this research project