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Biodiversity of marine algae and metabolites of economical impact

Abstract

Marine algae have to develop defense strategies, in order to survive in a competitive environment, that result in a tremendous diversity of compounds from different metabolic pathways. Recent trends in drug research from natural sources have shown that algae are promising organisms to furnish novel biochemically active compounds. The aim of this project is to study the compounds biosynthesized by algae with potential economic impact in food science, public health, pharmaceutical, cosmetic and agriculture industries. Emphasis is given to antioxidants, fatty acids (specially omega 3 and 6 families), aminoacids, carotenoids, steroids, polysaccharides, and UV absorber molecules (mycosporine-like amino acids, MAA). Macroalgae will be collected at marine coastal of Brazil and in Atartica. Assays will be performed in which includes anticancer, leishmanicide, schistosomacide activities and enzymes such as acetylcolineterase, topoisomerases, superoxide dismutase and catalase. Extracts with potential activities will be purifies and the chemical structure elucidated. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
STEIN, ERIKA M.; TAJU, SARA G.; MIYASATO, PATRICIA A.; DE FREITAS, RAFAELA P.; TALLARICO, LENITA DE F.; DOS SANTOS, GUILHERME S.; LUIZ, GIOVANA L. F.; ROFATTO, HENRIQUE K.; DA SILVA, FABIO N. V.; COLEPICOLO, PIO; MACEDO, ARTHUR L.; CAROLLO, CARLOS A.; NAKANO, ELIANA. The Prospective Use of Brazilian Marine Macroalgae in Schistosomiasis Control. MARINE DRUGS, v. 19, n. 5 MAY 2021. Web of Science Citations: 0.
RANGEL, KAREN CRISTINA; VILLELA, LEONARDO ZAMBOTTI; PEREIRA, KARINA DE CASTRO; COLEPICOLO, PIO; DEBONSI, HOSANA MARIA; GASPAR, LORENA RIGO. Assessment of the photoprotective potential and toxicity of Antarctic red macroalgae extracts from Curdiea racovitzae and Iridaea cordata for cosmetic use. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, v. 50, SEP 2020. Web of Science Citations: 0.
GUILHERME, JULIANA ROCHA; PACHECO, BRUNA; SOARES, BRUNO MEIRA; PEREIRA DE PEREIRA, CLAUDIO MARTIN; COLEPICOLO, PIO; DIAS, DAIANE. Phaeophyceae and rhodophyceae macroalgae from the Antarctic: A source of selenium. Journal of Food Composition and Analysis, v. 88, MAY 2020. Web of Science Citations: 0.
SPAGOLLA NAPOLEAO TAVARES, RENATA; STUCHI MARIA-ENGLER, SILVYA; COLEPICOLO, PIO; DEBONSI, HOSANA MARIA; SCHAEFER-KORTING, MONIKA; MARX, UWE; RIGO GASPAR, LORENA; ZOSCHKE, CHRISTIAN. Skin Irritation Testing beyond Tissue Viability: Fucoxanthin Effects on Inflammation, Homeostasis, and Metabolism. PHARMACEUTICS, v. 12, n. 2 FEB 2020. Web of Science Citations: 0.
TEIXEIRA, THAIZ RODRIGUES; DOS SANTOS, GUSTAVO SOUZA; ARMSTRONG, LORENE; COLEPICOLO, PIO; DEBONSI, HOSANA MARIA. Antitumor Potential of Seaweed Derived-Endophytic Fungi. ANTIBIOTICS-BASEL, v. 8, n. 4 DEC 2019. Web of Science Citations: 0.
ALVES-LIMA, CICERO; AZEVEDO TEIXEIRA, ANDRE REIS; HOTTA, CARLOS TAKESHI; COLEPICOLO, PIO. A cheap and sensitive method for imaging Gracilaria (Rhodophyta, Gracilariales) growth. JOURNAL OF APPLIED PHYCOLOGY, v. 31, n. 2, p. 885-892, APR 2019. Web of Science Citations: 0.
RANGEL, KAREN C.; DEBONSI, HOSANA M.; CLEMENTINO, LEANDRO C.; GRAMINHA, MARCIA A. S.; VILELA, LEONARDO Z.; COLEPICOLO, PIO; GASPAR, LORENA R. Antileishmanial activity of the Antarctic red algae Iridaea cordata (Gigartinaceae; Rhodophyta). JOURNAL OF APPLIED PHYCOLOGY, v. 31, n. 2, p. 825-834, APR 2019. Web of Science Citations: 0.

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