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Scientific bases for residual malaria elimination in the Brazilian Amazon

Grant number: 16/18740-9
Support type:Research Projects - Thematic Grants
Duration: June 01, 2017 - May 31, 2022
Field of knowledge:Biological Sciences - Parasitology - Protozoology of Parasites
Principal Investigator:Marcelo Urbano Ferreira
Grantee:Marcelo Urbano Ferreira
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Paulo Eduardo Martins Ribolla
Assoc. researchers: Carlos Eugênio Cavasini ; João Marcelo Pereira Alves ; Marcia Caldas de Castro ; Maria Gabriela Miranda Gomes
Associated grant(s):20/04505-3 - Tracking the community-wide spread of SARS-CoV-2: outbreak size, transmission dynamics, clinical outcomes of infection, and duration of naturally acquired antibody responses in an Amazonian town, AP.R
19/23139-0 - The clinically silent Plasmodium vivax reservoir in the Amazon: a systematic review and pooled analysis of individual-level data from population-based surveys, AP.R SPRINT
18/18931-4 - Optimizing ex-vivo erythrocyte reinvasion assays for Plasmodium vivax, AV.EXT
+ associated grants 17/11376-2 - Multi-user equipment approved in grant 2016/18740-9: Real-Time PCR equipment QuantStudio 6 flex (Applied Biosystems), AP.EMU
17/11379-1 - Multiuser equipment approved in grant 2016/18740-9: QIAsymphony SP automated DNA/RNA extraction platform, Qiagen, AP.EMU
17/11380-0 - Multi-user equipment approved in grant 16/18740-9: server HPE DL 580 Gen9, AP.EMU - associated grants
Associated scholarship(s):18/12127-9 - Molecular epidemiology of Malaria in the Juruá Valley, BP.DD
18/03902-9 - Spatial and temporal dynamics of malaria transmission in residual hotspots in the Brazilian Amazon, BP.PD
17/25591-2 - Functional characterization of antibodies against Plasmodium vivax merozoite surface protein MSP-119, BP.MS

Abstract

With 143,910 laboratory-confirmed cases and 41 malaria-related deaths in 2014, Brazil has now the lowest malaria burden in 35 years, with transmission virtually limited to the Amazon Basin. Accordingly, the Ministry of Health of Brazil has launched, in November 2015, the Malaria Elimination Plan, with the short-term goal of interrupting Plasmodium falciparum transmission countrywide over the next 15 years. The focal nature of malaria transmission in Brazil suggests that elimination efforts will require a careful prioritization of a few residual malaria pockets. Here we combine classical epidemiological approaches, to characterize risk factors and intervention targets, with population genetics/genomics analyses of parasites and studies of vector biology and control, with the ultimate goal of improving current strategies for malaria control and elimination in Brazil. Our field-based studies in the main endemic area of Brazil (Juruá Valley, close to the border with Peru, which accounts for 20% of all infections in this country) are complemented with mathematical modelling of different malaria elimination scenarios. We focus on two main challenges for malaria elimination: (a) the presence of asymptomatic infections with low-level parasitemias that are often below the detection threshold of available diagnostic techniques, creating a large and undetected reservoir of infection, and (b) the maintenance of high vector densities resulting from new man-made mosquito breeding sites (fish pounds opened across Juruá Valley for commercial aquaculture). (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre o auxílio:
FAPESP selects first projects in call to combat COVID-19 
Malaria parasite in the Americas is more genetically diverse than previously thought 

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CORDER, RODRIGO M.; DE LIMA, ANTONIO C. P.; KHOURY, DAVID S.; DOCKEN, STEFFEN S.; DAVENPORT, MILES P.; FERREIRA, MARCELO U. Quantifying and preventingPlasmodium vivaxrecurrences in primaquine-untreated pregnant women: An observational and modeling study in Brazil. PLoS Neglected Tropical Diseases, v. 14, n. 7 JUL 2020. Web of Science Citations: 0.
CORDER, RODRIGO M.; FERREIRA, MARCELO U.; GOMES, M. GABRIELA M. Modelling the epidemiology of residual Plasmodium vivax malaria in a heterogeneous host population: A case study in the Amazon Basin. PLOS COMPUTATIONAL BIOLOGY, v. 16, n. 3 MAR 2020. Web of Science Citations: 0.
RANGEL, GABRIEL W.; CLARK, MARTHA A.; KANJEE, USHEER; GOLDBERG, JONATHAN M.; MACINNIS, BRONWYN; MENEZES, MARIA JOSE; FERREIRA, MARCELO U.; DURAISINGH, MANOJ T. Plasmodium vivax transcriptional profiling of low input cryopreserved isolates through the intraerythrocytic development cycle. PLoS Neglected Tropical Diseases, v. 14, n. 3 MAR 2020. Web of Science Citations: 0.
CORDER, RODRIGO M.; PAULA, GILBERTO A.; PINCELLI, ANACLARA; FERREIRA, MARCELO U. Statistical modeling of surveillance data to identify correlates of urban malaria risk: A population-based study in the Amazon Basin. PLoS One, v. 14, n. 8 AUG 9 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.