Bioinformatics, Chemiogenomics and Chemioinformatics applied to the Discovery of New Drugs and Biotechnological Products

• Grant number: 17/02353-9
• Support type: Research Grants - Visiting Researcher Grant - Brazil
• Duration: May 30, 2017 - May 29, 2018
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Principal researcher: Fabio Trindade Maranhão Costa
• Grantee: Fabio Trindade Maranhão Costa
• Visiting researcher: Carolina Horta Andrade
• Visiting researcher institution: Universidade Federal de Goiás (UFG). Faculdade de Farmácia, Brazil
• Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 12/16525-2 - Plasmodium vivax: pathogenesis and infectivity, AP.TEM

Abstract

The current proposal aims to strengthen the scientific cooperation between UFG-GO and UNICAMP, through the host of Prof. Carolina Horta Andrade, as Visiting Researcher. The hosting of Prof. Carolina Andrade will attend two research projects, one Thematic and one Young Investigator (see attached summaries in SAGE) due to the complementary nature of these projects and the profile of Prof. Andrade. Therefore, the following activities are planned; (I) presentation of seminars and workshops at Universities of São Paulo state (UNICAMP, USP-São Paulo, USP-São Carlos); (ii) elaboration of research projects in collaboration, taking advantage of Prof. Andrade's collaborative network; (iii) training of undergraduate and graduate students through didactic activities, such as collaboration in the course "Physiopathogenesis of emerging diseases and application of computational tools for the discovery of therapeutic targets and drugs", in the Post-Graduation Program in Genetics and Molecular Biology and another discipline in the recently created Post-Graduation Program in Pharmaceutical Sciences of UNICAMP, and (iv) co-orientation of master's and doctoral students.Regarding the research, the Visiting Researcher will collaborate in projects that are underway in the Laboratory coordinated by Prof. Fabio TM Costa (Thematic project coordinator) and Profa. Elizabeth Bilsland (Coordinator of the Young Researcher - see attached curriculum attached to SAGE), as well as collaboration with other ongoing research projects of UNICAMP, USP-SP, USP-São Carlos and Instituto Adolfo Lutz, in which Dr. Carolina Horta already has collaborations in progress. Dr. Andrade has expertise in the development and application of Computer-Aided Drug Design (CADD) tools such as; virtual screening, bioinformatics, chemogenomics, chemoinformatics and development of platforms for in silico modeling of pharmacokinetic properties and toxicity. Regarding to training and teaching, Dr. Andrade has experience in teaching and mentoring Master's and Ph.D. students in two postgraduate programs at UFG: Postgraduate Program in Pharmaceutical Sciences (PPGCF) and Postgraduate Program in Tropical Medicine and Public Health (PPGMTSP), in addition to a Network Program with UFPA, UFAM and UNIFAP, the Postgraduate Program in Pharmaceutical Innovation (PPGIF). The dissertations and theses oriented so far by Prof. Carolina are focused on the design and discovery of drug candidates for parasitic diseases, areas of interest of the host principal investigator Dr. Fabio T. M. Costa and of Profa. Elizabeth Bilsland. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTOS, DANIELA BRAZ DOS; MOREIRA-FILHO, JOSE TEOFILO; MELO, AMANDA DE OLIVEIRA; LEMES, JOSIEL ARAUJO; DAMACENA SILVA, LUCIANA; ROCHA, THIAGO LOPES; ANDRADE, CAROLINA HORTA; NEVES, BRUNO JUNIOR; BEZERRA, JOSE CLECILDO BARRETO. In silico-driven identification of novel molluscicides effective against Biomphalaria glabrata (Say, 1818). NEW JOURNAL OF CHEMISTRY, v. 44, n. 39, p. 16948-16958, OCT 21 2020. Web of Science Citations: 0.

NEVES, BRUNO J.; BRAGA, RODOLPHO C.; ALVES, VINICIUS M.; LIMA, MARILIA N. N.; CASSIANO, GUSTAVO C.; MURATOV, EUGENE N.; COSTA, FABIO T. M.; ANDRADE, CAROLINA HORTA. Deep Learning-driven research for drug discovery: Tackling Malaria. PLOS COMPUTATIONAL BIOLOGY, v. 16, n. 2 FEB 2020. Web of Science Citations: 0.

LIMA, MARILIA N. N.; CASSIANO, GUSTAVO C.; TOMAZ, KAIRA C. P.; SILVA, ARTHUR C.; SOUSA, BRUNA K. P.; FERREIRA, LETICIA T.; TAVELLA, TATYANA A.; CALIT, JULIANA; BARGIERI, DANIEL Y.; NEVES, BRUNO J.; COSTA, FABIO T. M.; ANDRADE, CAROLINA HORTA. Integrative Multi-Kinase Approach for the Identification of Potent Antiplasmodial Hits. FRONTIERS IN CHEMISTRY, v. 7, NOV 21 2019. Web of Science Citations: 0.

LIMA, MARILIA N. N.; NEVES, BRUNO J.; CASSIANO, GUSTAVO C.; GOMES, MARCELO N.; TOMAZ, KAIRA C. P.; FERREIRA, LETICIA T.; TAVELLA, TATYANA A.; CALIT, JULIANA; BARGIERI, DANIEL Y.; MURATOV, EUGENE N.; COSTA, FABIO T. M.; ANDRADE, CAROLINA HORTA. Chalcones as a basis for computer-aided drug design: innovative approaches to tackle. Future Medicinal Chemistry, v. 11, n. 20, p. 2635-2646, OCT 2019. Web of Science Citations: 0.

MOTTIN, MELINA; BORBA, JOYCE V. V. B.; BRAGA, RODOLPHO C.; TORRES, PEDRO H. M.; MARTINI, MATHEUS C.; PROENCA-MODENA, JOSE LUIZ; JUDICE, CARLA C.; COSTA, FABIO T. M.; EKINS, SEAN; PERRYMAN, ALEXANDER L.; ANDRADE, CAROLINA HORTA. The A-Z of Zika drug discovery. DRUG DISCOVERY TODAY, v. 23, n. 11, p. 1833-1847, NOV 2018. Web of Science Citations: 10.

LIMA, MARILIA N. N.; MELO-FILHO, CLEBER C.; CASSIANO, GUSTAVO C.; NEVES, BRUNO J.; ALVES, VINICIUS M.; BRAGA, RODOLPHO C.; CRAVO, PEDRO V. L.; MURATOV, EUGENE N.; CALIT, JULIANA; BARGIERI, DANIEL Y.; COSTA, FABIO T. M.; ANDRADE, CAROLINA H. QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities. FRONTIERS IN PHARMACOLOGY, v. 9, MAR 6 2018. Web of Science Citations: 4.