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Vertical infection by the virus Zika and its impact on the mother-child area

Grant number: 16/08578-0
Support type:Research Projects - Thematic Grants
Duration: April 01, 2017 - March 31, 2022
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Saulo Duarte Passos
Grantee:Saulo Duarte Passos
Home Institution: Faculdade de Medicina de Jundiaí (FMJ). Prefeitura Municipal de Jundiaí. Jundiaí , SP, Brazil
Co-Principal Investigators:Antonio Fernandes Moron
Assoc. researchers: Adriana Cruanes Mingotti ; Alexandra Siqueira Mello ; Ana Paula Antunes Pascalicchio Bertozzi ; André Prado Grion ; Andréa Cristina Botelho Silva ; Annemeri Livinalli ; Clóvis Antonio Lopes Pinto ; Danielle Bruna Leal de Oliveira ; Danila Soares Tambalo ; Dora Selma Fix Ventura ; Edison Luiz Durigon ; Eduardo José Caldeira ; Eduardo Massad ; Felipe Favorette Campanharo ; Fernanda Alves Cangerana Pereira ; Fernanda Guerra Velasco ; Francisco Del Moral Hernandez ; Geovane Ribeiro Santos ; Gilberto Lazaroni Theodoro da Cunha ; Hérbene José Figuinha Milani ; Hyun Mo Yang ; Karen Richter Comandulli ; Laura Cunha Rodrigues ; Leslie Domenici Kulikowski ; Lourival Benedito de Oliveira ; Magda Maria Sales Carneiro-Sampaio ; Marcia Borges Machado ; Margareth Martha Arilha Silva ; Maria Manoela Duarte Rodrigues ; Marielze Pinto da Paixão ; Mauricio Mendes Barbosa ; Mayana Zatz ; Milene Tavares Batista ; Nemésio Florence Vieira Filho ; Paolo Marinho de Andrade Zanotto ; Patricia Cristina Baleeiro Beltrão Braga ; Patricia Palmeira Daenekas Jorge ; Rafael Izbicki ; Raquel Prestes ; Rita de Cássia de Aguirre Bernardes Dezena ; Ronei Luciano Mamoni ; Rosa Estela Gazeta ; Sandra Helena Alves Bonon ; Stéphanno Gomes Pereira Sarmento ; Thamirys Cosmo Grillo Fajardo ; Viviane Cristina Martori Pandini
Associated grant(s):20/05298-1 - Multi-User Equipment approved in the process 2018/08578-0: brainstem evoked response audiometer, AP.EMU
18/15031-2 - Immune and inflammatory repercussions of congenital infections in the perinatal period, AV.EXT
Associated scholarship(s):20/04342-7 - Seroepidemiology of Mayaro virus ín high-risk pregnant women from “The Zika Jundiaí cohort seropositive for Chikungunya Virus, BP.IC
20/08613-5 - The role of nursing in improving the quality of prenatal care, delivery and puerperium in pregnant women with Zika virus infection, BP.TT
19/21144-7 - Vertical infection by the Virus Zika and its impact on the mother-child area, BP.PD
+ associated scholarships 19/08399-6 - Prevalence of congenital anomalies in children born at the Hospital Universitário de Jundiaí, from 2006 to 2016, BP.IC
19/04883-0 - “The role of nursing ín improving “The quality of prenatal care, delivery ánd puerperium ín pregnant women with Zika Virus infection, BP.TT
18/20917-0 - Vertical infection by the Zika virus and its repercussions in the maternal-infant area, BP.TT
18/20918-6 - Vertical infection by the Zika virus and its repercussions in the maternal-infant area, BP.TT
18/06131-3 - Prevention, knowledge and practice about Zika virus among pregnant women and new mothers - Jundiaí, BP.IC
17/22007-8 - Vertical infection by the virus Zika and its impact on the mother-child area, BP.PD - associated scholarships

Abstract

The maternal-fetal transmission of viruses is well known to cause serious consequences to the fetus during pregnancy. Although there is a link between the Zika Virus (ZIKV) and microcephaly, the specter of other associations of pregnancy and birth defects need to be clarified during the first few months or years of life of children. Global alerts have been issued in this regard. Our objectives determine the incidence of infection caused by ZIKV in pregnant women and neonates born in the cohort, as well as analyze, describe the spectrum of clinical presentation of pregnant women ZIKV (+) and identify, describe and quantify the spectrum of anomalies and/or results, including microcephaly, in fetuses and newborn babies of pregnant women participating in the cohort. To develop these project, a prospective cohort study nested case-control as well as qualitative study of maternal mental health will be conducted at the University Hospital of the Faculty of Medicine of Jundiaí from 2016-2021. The sampling stipulated of the 500 pregnant women will be divided into three groups: Group I (high-risk pregnant women without symptoms); Group II (low-risk pregnant women with symptoms); and Group III (abortions); and their newborns (RN) divided into those with or without microcephaly. The RN will be divided by maternal gestational age and will be used logistic regression controlled for possible confounders. Following these, we will assess the psychomotor development and the occurrence of hearing and visual losses, and neurological involvement. Active monitoring of cases will be done weekly by telephone of pregnant women. The biological samples (blood, urine, saliva and cerebrospinal fluid) will be collected and examined by serological tests: ELISA Microarray, RT-PCR and RNA-Sequencing. The human tissues will be analyzed by pathology. Predictors will aim to calculate the risk relative, the risk univariate and multiple logistic models, when appropriate. Altogether, data will allow correlating the incidence of Zika infection and its potential as a causative agent of newborn and infant mental/physical health disorders. The project is innovative and will help researchers to understand the impact of this emergent disease on the population, especially in children. (AU)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CLEMENTE, NURIA SANCHEZ; BRICKLEY, ELIZABETH B.; PAIXAO, ENNY S.; DE ALMEIDA, MARCIA F.; GAZETA, ROSA E.; VEDOVELLO, DANILA; RODRIGUES, LAURA C.; WITKIN, STEVEN S.; PASSOS, SAULO D. Zika virus infection in pregnancy and adverse fetal outcomes in SAo Paulo State, Brazil: a prospective cohort study. SCIENTIFIC REPORTS, v. 10, n. 1 JUL 29 2020. Web of Science Citations: 0.
SANTOS, GEOVANE R.; PINTO, CLOVIS A. L.; PRUDENTE, RAPHAEL C. S.; BEVILACQUA, ESTELA M. A. F.; WITKIN, STEVEN S.; PASSOS, SAULO D.; MORON, A. F.; VENTURA, D. F.; MASSAD, E.; ZANOTTO, P. M. A.; RODRIGUES, L. C.; BERTOZZI, A. P. A. P.; GRION, A. P.; MINGOTTI, A. C.; SILVA, A. C. B.; MARTINS, C. M. G.; BARREIRA, E. R.; FUJIWARA, D. T.; SOUZA, F. M. S.; VELASCO, F. G.; CANGERANA, F.; ARITA, F. N.; HERNANDEZ, F. D. M.; TABARES, H. S.; MILANI, H. J. F.; SAMPAIO, M. M. S. C.; MACHADO, M. B.; SILVA, M. M. A.; RODRIGUES, M. M. D.; ALMEIDA, M. F.; RIZZO, M. F.; DAMICO, F. M.; CLEMENTE, N. S.; CUNHA, M. P.; IZBICKI, R.; GAZETA, R. E.; DEZENA, R. C. A. B.; BONOM, S. H. A.; POUR, S. Z.; URANJEC, S.; ROSEMBERG, S.; OYAMA, S. M. R.; SARMENTO, S. G. P.; QUINTELLA, T. M.; FAJARDO, T. C. G.; FERRARETO, T. R. G.; RODRIGUES, W. M.; BARAN, L.; SOARES, A. P.; COSTA, M.; BARBONI, M. T. S.; LIMA, DS; FRANCA, V. C. R. M.; VIDAL, K. S.; BARBOSA, A. R.; ZANQUETTA, G. U.; SILVA, A. B.; GRP, ZIKA VIRUS COHORT STUDY. Histopathologic Changes in Placental Tissue Associated With Vertical Transmission of Zika Virus. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, v. 39, n. 2, p. 157-162, MAR 2020. Web of Science Citations: 1.
VEDOVELLO, DANILA; WITKIN, STEVEN S.; BOTELHO SILVA, ANDREA CRISTINA; GILLO FAJARDO, THAMIRYS COSMO; MELLO, ALEXANDRA SIQUEIRA; ANTUNES PASCALICCHIO BERTOZZI, ANA PAULA; DA SILVA, ALIFY BERTOLDO; VIEIRA FILHO, NEMESIO FLORENCE; DUARTE RODRIGUES, MARIA MANOELA; GAZETA, ROSA ESTELA; MORON, ANTONIO FERNANDES; PEREIRA SARMENTO, STEPHANNO GOMES; SORIANO-ARANDES, ANTONIO; PASSOS, SAULO DUARTE. Detection of Zika virus in paired urine and amniotic fluid samples from symptomatic and asymptomatic women and their babies during a disease outbreak: association with neurological symptoms in newborns. JOURNAL OF NEUROVIROLOGY, v. 26, n. 1, p. 70-76, FEB 2020. Web of Science Citations: 0.
CLEMENTE, NURIA SANCHEZ; RODRIGUES, MANOELA; PASCALICCHIO, ANA PAULA; GAZETA, ROSA ESTELA; VEDOVELLO, DANILA; BRICKLEY, ELIZABETH B.; DE ALMEIDA, MARCIA F.; PASSOS, SAULO D. Cohort profile: the Jundiai Zika cohort (JZC), a pregnancy and birth cohort in SAo Paulo state, Brazil. BMJ OPEN, v. 9, n. 8 AUG 2019. Web of Science Citations: 0.
MELLO, ALEXANDRA SIQUEIRA; PASCALICCHIO BERTOZZI, ANA PAULA A.; RODRIGUES, MARIA MANOELA D.; GAZETA, ROSA ESTELA; MORON, ANTONIO F.; SORIANO-ARANDES, ANTONI; PEREIRA SARMENTO, STEPHANNO GOMES; VEDOVELLO, DANILA; SILVA, ANDREA CRISTINA B.; GRILLO FAJARDO, THAMIRYS C.; WITKIN, STEVEN S.; PASSOS, SAULO D.; CONSORTIUM, COHORT ZIKA JUNDIAI. Development of Secondary Microcephaly After Delivery: Possible Consequence of Mother-Baby Transmission of Zika Virus in Breast Milk. AMERICAN JOURNAL OF CASE REPORTS, v. 20, p. 723-725, MAY 21 2019. Web of Science Citations: 0.

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