| Grant number: | 16/08578-0 |
| Support Opportunities: | Research Projects - Thematic Grants |
| Start date: | April 01, 2017 |
| End date: | April 30, 2023 |
| Field of knowledge: | Health Sciences - Medicine - Maternal and Child Health |
| Principal Investigator: | Saulo Duarte Passos |
| Grantee: | Saulo Duarte Passos |
| Host Institution: | Faculdade de Medicina de Jundiaí (FMJ). Jundiaí , SP, Brazil |
| City of the host institution: | Jundiaí |
| Principal investigators | Antonio Fernandes Moron |
| Associated researchers: | Adriana Cruanes Mingotti ; Alexandra Siqueira Mello ; Ana Paula Antunes Pascalicchio Bertozzi ; Andre Prado Grion ; Andréa Cristina Botelho Silva ; Annemeri Livinalli ; Antonio Carlos de Quadros Junior ; Clóvis Antonio Lopes Pinto ; Danielle Bruna Leal de Oliveira ; Danila Soares Tambalo ; Dora Selma Fix Ventura ; Edison Luiz Durigon ; Eduardo José Caldeira ; Eduardo Massad ; Emmanuel Machado Oliveira ; Fábio Valente Rizzo ; Felipe Favorette Campanharo ; Fernanda Alves Cangerana Pereira ; Fernanda Guerra Velasco ; Francisco del Moral Hernandez ; Geovane Ribeiro Santos ; Gilberto Lazaroni Theodoro da Cunha ; Hérbene José Figuinha Milani ; Hyun Mo Yang ; Karen Richter Comandulli ; Laura Cunha Rodrigues ; Leslie Domenici Kulikowski ; Lourival Benedito de Oliveira ; Luiz Dias da Silva ; Magda Maria Sales Carneiro-Sampaio ; Marcia Borges Machado ; Márcia Elisabeth Rodrigues ; Margareth Martha Arilha Silva ; Maria Emília De Domenico Garcia ; Maria Manoela Duarte Rodrigues ; Marielze Pinto da Paixão ; Mauricio Mendes Barbosa ; Mayana Zatz ; Milene Tavares Batista ; Mirella Nayane Barbosa Leite ; Nemésio Florence Vieira Filho ; Paolo Marinho de Andrade Zanotto ; Patricia Carvalho Loiola ; Patricia Cristina Baleeiro Beltrão Braga ; Patricia Palmeira Daenekas Jorge ; Rafael Izbicki ; Raquel Prestes ; Renata Maria Mizani ; Rita de Cássia de Aguirre Bernardes Dezena ; Ronei Luciano Mamoni ; Rosa Estela Gazeta ; Sandra Helena Alves Bonon ; Stéphanno Gomes Pereira Sarmento ; Thamirys Cosmo Grillo Fajardo ; Viviane Cristina Martori Pandini |
| Associated research grant(s): | 20/05298-1 - Multi-User Equipment approved in the process 2018/08578-0: brainstem evoked response audiometer,
AP.EMU 18/15031-2 - Immune and inflammatory repercussions of congenital infections in the perinatal period, AV.EXT |
| Associated scholarship(s): | 20/04342-7 - Seroepidemiology of Mayaro Virus in high-risk pregnant women from the Zika Jundiaí Cohort seropositive for Chikungunya Virus,
BP.IC 20/08613-5 - The role of nursing in improving the quality of prenatal care, delivery and puerperium in pregnant women with Zika virus infection, BP.TT 19/21144-7 - Vertical infection by the Virus Zika and its impact on the mother-child area, BP.PD + associated scholarships - associated scholarships |
Abstract
The maternal-fetal transmission of viruses is well known to cause serious consequences to the fetus during pregnancy. Although there is a link between the Zika Virus (ZIKV) and microcephaly, the specter of other associations of pregnancy and birth defects need to be clarified during the first few months or years of life of children. Global alerts have been issued in this regard. Our objectives determine the incidence of infection caused by ZIKV in pregnant women and neonates born in the cohort, as well as analyze, describe the spectrum of clinical presentation of pregnant women ZIKV (+) and identify, describe and quantify the spectrum of anomalies and/or results, including microcephaly, in fetuses and newborn babies of pregnant women participating in the cohort. To develop these project, a prospective cohort study nested case-control as well as qualitative study of maternal mental health will be conducted at the University Hospital of the Faculty of Medicine of Jundiaí from 2016-2021. The sampling stipulated of the 500 pregnant women will be divided into three groups: Group I (high-risk pregnant women without symptoms); Group II (low-risk pregnant women with symptoms); and Group III (abortions); and their newborns (RN) divided into those with or without microcephaly. The RN will be divided by maternal gestational age and will be used logistic regression controlled for possible confounders. Following these, we will assess the psychomotor development and the occurrence of hearing and visual losses, and neurological involvement. Active monitoring of cases will be done weekly by telephone of pregnant women. The biological samples (blood, urine, saliva and cerebrospinal fluid) will be collected and examined by serological tests: ELISA Microarray, RT-PCR and RNA-Sequencing. The human tissues will be analyzed by pathology. Predictors will aim to calculate the risk relative, the risk univariate and multiple logistic models, when appropriate. Altogether, data will allow correlating the incidence of Zika infection and its potential as a causative agent of newborn and infant mental/physical health disorders. The project is innovative and will help researchers to understand the impact of this emergent disease on the population, especially in children. (AU)
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