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The role of the innate and adaptive immune responses in oral leukoplakia and oral proliferative verrucous leukoplakia

Grant number: 17/01438-0
Support type:Regular Research Grants
Duration: May 01, 2017 - October 31, 2019
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal researcher:Andreia Bufalino
Grantee:Andreia Bufalino
Home Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Squamous cell carcinoma (SCC) accounts for more than 95% of all malignancies involving the oral cavity, and often these tumors are preceded by clinical alterations that have a clear potential for malignant transformation, which are denominated oral potentially malignant disorders (OPMDs). Among these, Oral Leukoplakia (OL) is the most important and has a malignant transformation rate ranging from 0.2% to 17.5%. Another important OPMD is Proliferative Verrucous Leukoplakia (PVL), which presents persistent and progressive malignant behavior, with a malignant transformation rate greater than 70%. Differently from OL, risk factors such as tobacco, alcohol and areca do not seem to be associated with the development of PVL. Additionally, a PVL presents an inadequate response to all treatment modalities, undergoes rapid spread for multiple oral sites and often presents recurrence. Recent studies and preliminary data obtained by our group suggest that the inflammatory infiltrate associated with the lesions of patients with PVL is related to the etiology and/or distinct clinical behavior from the conventional OL. Thus, this study intends to carry out a comparative analysis between OL and PVL samples consisting of: (1) evaluating a density and activation state of dendritic cells, (2) evaluating a density and polarization of macrophages M1 and M2, (3) evaluate the percentage and identify the subtypes of T-helpers lymphocytes and activation state of T-cytotoxic lymphocytes, and (4) determining the effect of soluble products and/or direct contact of dysplastic cells on the modulation of innate and adaptive immunity and evaluate whether such modulation confers or not an advantage to the tumor progression. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVEIRA, HEITOR ALBERGONI; TORAL-RIZO, VICTOR HUGO; LARA-CARRILLO, EDITH; DOMINGUETE, MATHEUS HENRIQUE LOPES; SILVA, EVANIO VILELA; RIBEIRO-SILVA, ALFREDO; BUFALINO, ANDREIA; ALMEIDA, LUCIANA YAMAMOTO; LEON, JORGE ESQUICHE. Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis. ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG, AUG 2021. Web of Science Citations: 0.
FERRISSE, TULIO MORANDIN; DE OLIVEIRA, ANALU BARROS; PALACON, MARIANA PARAVANI; SILVA, EVANIO VILELA; SGAVIOLI MASSUCATO, ELAINE MARIA; DE ALMEIDA, LUCIANA YAMAMOTO; LEON, JORGE ESQUICHE; BUFALINO, ANDREIA. The role of CD68+and CD163+macrophages in immunopathogenesis of oral lichen planus and oral lichenoid lesions. Immunobiology, v. 226, n. 3 MAY 2021. Web of Science Citations: 0.
FERRISSE, TULIO MORANDIN; DE OLIVEIRA, ANALU BARROS; PALACON, MARIANA PARAVANI; DA SILVEIRA, HEITOR ALBERGONI; SGAVIOLI MASSUCATO, ELAINE MARIA; DE ALMEIDA, LUCIANA YAMAMOTO; LEON, JORGE ESQUICHE; BUFALINO, ANDREIA. Immunohistochemical evaluation of Langerhans cells in oral lichen planus and oral lichenoid lesions. ARCHIVES OF ORAL BIOLOGY, v. 124, APR 2021. Web of Science Citations: 0.
CAMILA DE OLIVEIRA BARBEIRO; ROBERTO HENRIQUE BARBEIRO; HEITOR ALBERGONI DA SILVEIRA; LUCIANA YAMAMOTO DE ALMEIDA; JORGE ESQUICHE LEÓN; ANDREIA BUFALINO. Maxillary dentigerous cyst showing squamous odontogenic tumor-like proliferation: surgical approach and literature review. Autopsy and Case Reports, v. 11, p. -, 2021.
ARROYO, ESTEBAN; PINEIRO DONIS, SERGIO; CHAMORRO PETRONACCI, CINTIA M.; OLIVEIRA ALVES, MONICA G.; MARICHALAR MENDIA, XABIER; FERNANDES, DARCY; LORENZO POUSO, I, ALEJANDRO; BUFALINO, ANDREIA; BRAVO LOPEZ, SUSANA; PEREZ SAYANS, MARIO. Usefulness of protein-based salivary markers in the diagnosis of oral potentially malignant disorders: A systematic review and meta-analysis. CANCER BIOMARKERS, v. 32, n. 4, p. 411-424, 2021. Web of Science Citations: 1.

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