Antilipoperoxidative and anti-inflammatory effects of multifunctional sunscreens containing ferulic acid

• Grant number: 16/24360-4
• Support Opportunities: Regular Research Grants
• Duration: May 01, 2017 - July 31, 2019
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: André Rolim Baby
• Grantee: André Rolim Baby
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Catarina Batista Fialho Rosado ; Rafael Sauce Silva

Abstract

Skin cancer is the most diagnosed cancer in the world, and its main cause is excessive exposure to ultraviolet (UV) radiation coming from the sun. Oxidative stress, one of the responsible factors for the development of carcinomas, is also associated with frequent exposure to UV radiation. The use of photoprotective formulations are the most effective measures to protect against the malignant effects of this type of radiation. Furthermore, they contain elements which absorb and / or reflect the radiations, and also contain components which may assist in skin homeostasis, such as antioxidants. The present study will use ferulic acid, a natural compound recognized as antioxidant activity, along with two sunscreens, bemotrizinol and triazone octyl, in the realization of biosafety and effectiveness methods, aiming the improvement of techniques and a better understanding of the effects of the ferulic acid. In vivo, in vitro and ex vivo techniques will be used to characterize elements such as irritability, inflammatory potential, antioxidative potential, permeability and hydration of the molecule. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

WROBLEWSKA, KATARZYNA BARBARA; BABY, ANDRE ROLIM; GROMBONE GUARATINI, MARIA TEREZA; HRIHOROWITSCH MORENO, PAULO ROBERTO. In vitro antioxidant and photoprotective activity of five native Brazilian bamboo species. INDUSTRIAL CROPS AND PRODUCTS, v. 130, p. 208-215, APR 2019. (16/24360-4)

SAUCE, RAFAEL; SALES DE OLIVEIRA PINTO, CLAUDINEIA APARECIDA; AYALA-JARA, CARMEN; PRIETO, ZULITA ADRIANA; ROBLES VELASCO, MARIA VALERIA; BABY, ANDRE ROLIM. Preliminary Protocol Development of a HPLC-TBARS-EVSC (Ex Vivo Stratum Corneum) Assay for Skin Research: Application in a Sunscreen System. SCIENTIA PHARMACEUTICA, v. 89, n. 2, 2021. (16/24360-4, 19/16169-0)

HUBNER, ALEXANDRA A.; SARRUF, FERNANDA D.; OLIVEIRA, CAMILA A.; NETO, V, ALBERTO; FISCHER, DOMINIQUE C. H.; KATO, EDNA T. M.; LOURENCO, FELIPE R.; BABY, ANDRE ROLIM; BACCHI, ELFRIEDE M.. Safety and Photoprotective Efficacy of a Sunscreen System Based on Grape Pomace (Vitis vinifera L.) Phenolics from Winemaking. PHARMACEUTICS, v. 12, n. 12, DEC 2020. (16/24360-4)

MARTINEZ, RENATA MILIANI; MAGALHAES, WAGNER VIDAL; SUFI, BIANCA DA SILVA; PADOVANI, GIOVANA; SBRUGNERA NAZATO, LUCAS IDACIR; ROBLES VELASCO, MARIA VALERIA; DA SILVA LANNES, SUZANA CAETANO; BABY, ANDRE ROLIM. Vitamin E-loaded bigels and emulsions: Physicochemical characterization and potential biological application. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 201, MAY 2021. (16/24360-4)

PERES, DANIELA D'ALMEIDA; SARRUF, FERNANDA DAUD; DE OLIVEIRA, CAMILA AREIAS; ROBLES VELASCO, MARIA VALERIA; BABY, ANDRE ROLIM. Ferulic acid photoprotective properties in association with UV filters: multifunctional sunscreen with improved SPF and UVA-PF. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 185, p. 46-49, AUG 2018. (16/24360-4)

ROBLES VELASCO, MARIA VALERIA; SAUCE, RAFAEL; DE OLIVEIRA, CAMILA AREIAS; DE OLIVEIRA PINTO, CLAUDINEIA A. S.; MARTINEZ, RENATA MILIANI; BAAH, STEPHANIE; ALMEIDA, TANIA SANTOS; ROSADO, CATARINA; BABY, ANDRE ROLIM. Active ingredients, mechanisms of action and efficacy tests of antipollution cosmetic and personal care products. Brazilian Journal of Pharmaceutical Sciences, v. 54, n. SI, 2018. (16/24360-4)

SAUCE, RAFAEL; SALES DE OLIVEIRA PINTO, CLAUDINEIA APARECIDA; ROBLES VELASCO, MARIA VALERIA; ROSADO, CATARINA; BABY, ANDRE ROLIM. Ex vivo penetration analysis and anti-inflammatory efficacy of the association of ferulic acid and UV filters. European Journal of Pharmaceutical Sciences, v. 156, JAN 1 2021. (19/16169-0, 16/24360-4)

HUBNER, ALEXANDRA; SOBREIRA, FLAVIA; NETO, ALBERTO VETORE; SALES DE OLIVEIRA PINTO, CLAUDINEIA APARECIDA; DARIO, MICHELLI FERRERA; COLLANTES DIAZ, INGRIT ELIDA; LOURENCO, FELIPE REBELLO; ROSADO, CATARINA; BABY, ANDRE ROLIM; BACCHI, ELFRIEDE MARIANNE. The Synergistic Behavior of Antioxidant Phenolic Compounds Obtained from Winemaking Waste's Valorization, Increased the Efficacy of a Sunscreen System. ANTIOXIDANTS, v. 8, n. 11, NOV 2019. (16/24360-4)