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Development of serological assay for Zika virus IgG and IgM based on low coast ELISA

Grant number: 16/08727-5
Support type:Research Grants - Innovative Research in Small Business - PIPE
Duration: February 01, 2017 - September 30, 2019
Field of knowledge:Biological Sciences - Microbiology
Cooperation agreement: FINEP - PIPE/PAPPE Grant
Principal Investigator:Danielle Bruna Leal de Oliveira
Grantee:Danielle Bruna Leal de Oliveira
Empresas:Meios de Cultura Barth Ltda. - ME (Filial)
COMERCIO IMPORTACAO E EXPORTACAO BIOSCAN LTDA
City: Itu
Co-Principal Investigators:Edison Luiz Durigon ; Luis Carlos de Souza Ferreira
Assoc. researchers:Roxane Maria Fontes Piazza ; Viviane Fongaro Botosso

Abstract

The present invention describes the identification, production and testing of a recombinant ZIKV antigen which allows the development of specific serological tests for those infected with the virus. Unlike tests available on the market, the present antigen detected specifically antibodies produced in ZIKV-infected patients even from people which were infected previously by other flavivirus such DENV, making this antigen suitable for use in endemic regions for DENV and other arboviruses. In addition, this antigen allowed the identification of ZIKV-infected people years after infection, in a simple, fast and inexpensive way. (AU)

Articles published in Agência FAPESP about the research grant
Test detects prior infection by Zika virus  

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA, DANIELLE B. L.; DURIGON, GIULIANA S.; MENDES, ERICA A.; LADNER, JASON T.; ANDREATA-SANTOS, ROBERT; ARAUJO, DANIELLE B.; BOTOSSO, VIVIANE F.; PAOLA, NICHOLAS D.; NETO, DANIEL F. L.; CUNHA, MARIELTON P.; BRACONI, CARLA T.; ALVES, RUBENS P. S.; JESUS, MONICA R.; PEREIRA, LENNON R.; MELO, STELLA R.; MESQUITA, FLAVIO S.; SILVEIRA, VANESSA B.; THOMAZELLI, LUCIANO M.; FAVORETTO, SILVANA R.; ALMONFREY, FRANCIANE B.; ABDULKADER, REGINA C. R. M.; GABRILI, JOEL M.; TAMBOURGI, DENISE V.; OLIVEIRA, SERGIO F.; PRIETO, KARLA; WILEY, MICHAEL R.; FERREIRA, LUIS C. S.; SILVA, MARCOS V.; PALACIOS, GUSTAVO F.; ZANOTTO, PAOLO M. A.; DURIGON, EDISON L. Persistence and Intra-Host Genetic Evolution of Zika Virus Infection in Symptomatic Adults: A Special View in the Male Reproductive System. Viruses-Basel, v. 10, n. 11 NOV 2018. Web of Science Citations: 1.
BARBOSA, CARLA M.; DI PAOLA, NICHOLAS; CUNHA, MARIELTON P.; RODRIGUES-JESUS, MONICA J.; ARAUJO, DANIELLE B.; SILVEIRA, VANESSA B.; LEAL, FABYANO B.; MESQUITA, FLAVIO S.; BOTOSSO, VIVIANE F.; ZANOTTO, PAOLO M. A.; DURIGON, EDISON L.; SILVA, MARCOS V.; OLIVEIRA, DANIELLE B. L. Yellow Fever Virus RNA in Urine and Semen of Convalescent Patient, Brazil. Emerging Infectious Diseases, v. 24, n. 1, p. 176-178, JAN 2018. Web of Science Citations: 13.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
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