Native American populations are the human group less studied as regards its genetic variability. Although the few studies using genomic array had helped to better understand the Native American populations structure, the genotyping platforms of this technique are based on the existing genetic variation of African, Asian and European populations, not taking into account the Native American variability, precisely because of the lack of reference genomes to be used. This lack of information has major implications in medical studies, since most of the studies of case-control performed today are done with conventional arrays, that are not suitable for studies in populations that exhibit large Native American component, like Mexicans, Peruvians and individuals from some regions of Brazil. The 1000 Genomes Project does not include the study of Native American populations, further increasing the neglect in the genetic information about these people. This project aims to fill this gap sequencing of 65 complete genomes of Native American populations in order to unlock the full genomic variability of these populations, establish the evolutionary processes involved in the generation and maintenance of this diversity, and assist in the development of high-fidelity methods for clinical studies involving admixed and Native American populations. (AU)
Articles published in Pesquisa FAPESP Magazine about the research grant:
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CASTRO E SILVA, MARCOS ARAUJO;
LEMES, RENAN BARBOSA;
GUERRA AMORIM, CARLOS EDUARDO;
KRIEGER, JOSE EDUARDO;
MILL, JOSE GERALDO;
SALZANO, FRANCISCO MAURO;
BORTOLINI, MARIA CATIRA;
PEREIRA, ALEXANDRE DA COSTA;
Genomic insight into the origins and dispersal of the Brazilian coastal natives.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
FEB 4 2020.
Web of Science Citations: 0.