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Role of physical training on autonomic balance, arterial stiffness and rarefaction in spontaneously hypertensive rats treated with dexamethasone: role of miRNA

Abstract

Hypertension is the main risk factor for cardiovascular diseases and has been considered an important health problem. We have previously shown that chronic dexamethasone (DEX) treatment determined hypertension; however, the responsible mechanisms are not completely elucidated. Since hypertensive individuals may have use DEX, is reasonable to think that DEX treatment would increase even more their blood pressure. This response could be associated with an autonomic unbalance to the heart, higher arterial stiffness and deleterious effects on microcirculation, which in turn could culminate in a drastic increase on morbi-mortality risk to these patients. Recently, researches with miRNA are growing and it is considered important to determine hypertension genesis, however, its role on DEX-induced hypertension was not investigated. Inversely, aerobic or combined training (T) have been recommended for hypertension treatment. Besides there are several evidences about the benefits of T, up to the moment, nothing is known about the contribution of the miRNA in this issue, and less is known about the benefits of T in hypertensive individuals with increased risk because of the DEX treatment. So, while pharmacological treatment is good to alleviate symptoms, miRNA therapies may influence on the source of the problem and being more promising. In this context, exercise training, modulating miRNA, may be a potent non-pharmacological strategy to attenuate side effects of medicines. So, the aim of this study is to investigate if aerobic or concurrent training are capable to modulate the autonomic balance, arterial stiffness and expression of miRNA related to vessel remodeling and microcirculation in spontaneously hypertensive rats treated with DEX. To answer these questions this project will associate functional (blood pressure and arterial stiffness) and structural (wall-to-lumen ratio, vessel density and elastic properties of vessel) techniques. These measurements will also be associated with molecular evaluations proteins and miRNAs-16,-21,-126,-143/145,-155,-205,-221 e -222, which are involved with remodeling and vessel density in normotensive and hypertensive rats, sedentary or trained, treated or not with DEX. (AU)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HERRERA, NAIARA A.; DUCHATSCH, FRANCINE; TARDELLI, LIDIELI P.; DIONISIO, THIAGO J.; SANTOS, CARLOS F.; AMARAL, SANDRA L. Dexamethasone Does Not Inhibit Treadmill Training-Induced Angiogenesis in Myocardium: Role of MicroRNA-126 Pathway. Journal of Cardiovascular Pharmacology, v. 76, n. 6, p. 708-714, DEC 2020. Web of Science Citations: 0.
DUCHATSCH, FRANCINE; TARDELLI, LIDIELI P.; HERRERA, NAIARA A.; RUIZ, THALLES F. R.; VICENTINI, CARLOS A.; OKOSHI, KATASHI; SANTOS, CARLOS F.; AMARAL, SANDRA L. Dexamethasone and Training-Induced Cardiac Remodeling Improve Cardiac Function and Arterial Pressure in Spontaneously Hypertensive Rats. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, v. 26, n. 2 AUG 2020. Web of Science Citations: 0.
HERRERA, NAIARA ARAUJO; DUCHATSCH, FRANCINE; KAHLKE, ALLISON; AMARAL, SANDRA LIA; VASQUEZ-VIVAR, JEANNETTE. In vivo vascular rarefaction and hypertension induced by dexamethasone are related to phosphatase PTP1B activation not endothelial metabolic changes. Free Radical Biology and Medicine, v. 152, p. 689-696, MAY 20 2020. Web of Science Citations: 0.
HERRERA, NAIARA A.; DUCHATSCH, FRANCINE; TARDELLI, LIDIELI P.; DIONISIO, THIAGO J.; SHINOHARA, ANDRE L.; SANTOS, CARLOS F.; AMARAL, SANDRA LIA. MicroRNA-126 upregulation, induced by training, plays a role in controlling microcirculation in dexamethasone treated rats. Molecular and Cellular Endocrinology, v. 505, APR 5 2020. Web of Science Citations: 0.
FABRICIO, MAYARA F.; JORDAO, MARIA T.; MIOTTO, DANYELLE S.; RUIZ, THALLES F. R.; VICENTINI, CARLOS A.; LACCHINI, SILVIA; SANTOS, CARLOS FERREIRA; MICHELINI, LISETE C.; AMARAL, SANDRA L. Standardization of a new non-invasive device for assessment of arterial stiffness in rats: Correlation with age-related arteries' structure. METHODSX, v. 7, 2020. Web of Science Citations: 0.

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